Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) damages dopaminergic neurons as seen in Parkinson disease. Here we show that after administration of MPTP to mice, there was a robust gliosis in the substantia nigra pars compacta associated with significant upregulation of inducible nitric oxide s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 1999-12, Vol.5 (12), p.1403-1409
Hauptverfasser:	Liberatore, Gabriel T., Jackson-Lewis, Vernice, Vukosavic, Slobodanka, Mandir, Allen S., Vila, Miquel, McAuliffe, W. Geoffrey, Dawson, Valina L., Dawson, Ted M., Przedborski, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research Disease Models, Animal Dopamine - metabolism Enzyme Inhibitors - pharmacology Gene Expression - drug effects Infectious Diseases Male Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Microglia - drug effects Microglia - enzymology Molecular Medicine MPTP Poisoning - drug therapy MPTP Poisoning - enzymology MPTP Poisoning - etiology Nerve Degeneration - drug therapy Nerve Degeneration - enzymology Nerve Degeneration - etiology Neurosciences Nitric Oxide Synthase - deficiency Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Parkinson Disease - drug therapy Parkinson Disease - enzymology Parkinson Disease - etiology RNA, Messenger - genetics RNA, Messenger - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!