"Weak toxin" from Naja kaouthia is a nontoxic antagonist of alpha 7 and muscle-type nicotinic acetylcholine receptors

A novel "weak toxin" (WTX) from Naja kaouthia snake venom competes with [(125)I]alpha-bungarotoxin for binding to the membrane-bound Torpedo californica acetylcholine receptor (AChR), with an IC(50) of approximately 2.2 microm. In this respect, it is approximately 300 times less potent tha...

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Veröffentlicht in:	The Journal of biological chemistry 2001-05, Vol.276 (19), p.15810-15815
Hauptverfasser:	Utkin, Y N, Kukhtina, V V, Kryukova, E V, Chiodini, F, Bertrand, D, Methfessel, C, Tsetlin, V I
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor Amino Acid Sequence Animals Binding, Competitive Bungarotoxins - pharmacokinetics Cell Membrane - drug effects Cell Membrane - physiology Cloning, Molecular Cobra Neurotoxin Proteins - pharmacology Elapid Venoms - chemistry Elapid Venoms - pharmacology Elapidae Escherichia coli Female Humans In Vitro Techniques Models, Molecular Muscle, Skeletal - physiology Naja kaouthia Neurotoxins - pharmacology Oocytes - drug effects Oocytes - physiology Protein Conformation Rats Receptors, Cholinergic - drug effects Receptors, Cholinergic - physiology Receptors, Nicotinic - drug effects Receptors, Nicotinic - physiology Recombinant Proteins - pharmacokinetics Torpedo Xenopus laevis
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