Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

Highlights • Atorvastatin reversed the development phase of morphine analgesic tolerance. • Atorvastatin mitigated the expression phase of analgesic tolerance to morphine. • Nitrergic system was involved in the effects of atorvastatin.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2016-07, Vol.125, p.173-180
Hauptverfasser:	Hassanipour, Mahsa, Amini-Khoei, Hossein, Shafaroodi, Hamed, Shirzadian, Armin, Rahimi, Nastaran, Imran-Khan, Muhammad, Rezayat, Seyed-Mahdi, Dehpour, Ahmadreza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antinociception Arginine - pharmacology Atorvastatin Atorvastatin Calcium - pharmacology Atorvastatin Calcium - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Drug Tolerance Enzyme Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Mice Morphine Morphine - adverse effects Narcotics - adverse effects Neurology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Opioid-Related Disorders - drug therapy Pain Measurement Pain Threshold - drug effects Signal Transduction - drug effects Tolerance
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Beschreibung
Zusammenfassung:	Highlights • Atorvastatin reversed the development phase of morphine analgesic tolerance. • Atorvastatin mitigated the expression phase of analgesic tolerance to morphine. • Nitrergic system was involved in the effects of atorvastatin.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2016.07.002