Natural products and their derivatives as tRNA synthetase inhibitors and antimicrobial agents

The tRNA synthetase enzymes are promising targets for development of therapeutic agents against infections by parasitic protozoans ( e.g. malaria), fungi and yeast, as well as bacteria resistant to current antibiotics. These ubiquitous enzymes load a particular amino acid onto its cognate tRNA to fo...

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Veröffentlicht in:MedChemComm 2016-08, Vol.7 (8), p.1535-1545
Hauptverfasser: Cochrane, R. V. K, Norquay, A. K, Vederas, J. C
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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