Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK

Cell migration within 3D interstitial microenvironments is sensitive to extracellular matrix (ECM) properties, but the mechanisms that regulate migration guidance by 3D matrix features remain unclear. To examine the mechanisms underlying the cell migration response to aligned ECM, which is prevalent...

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Veröffentlicht in:	Integrative biology (Cambridge) 2016-08, Vol.8 (8), p.821-835
Hauptverfasser:	Carey, Shawn P, Goldblatt, Zachary E, Martin, Karen E, Romero, Bethsabe, Williams, Rebecca M, Reinhart-King, Cynthia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisotropy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion Cell Line, Tumor Cell Movement Cell Surface Extensions Collagen - chemistry Extracellular Matrix - metabolism Female Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Mammary Neoplasms, Animal - metabolism Mice Neoplasm Invasiveness rac1 GTP-Binding Protein - metabolism Signal Transduction
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