Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression

The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found th...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-08, Vol.76 (16), p.4791-4804
Hauptverfasser:	Oh, Ah-Young, Jung, Youn Sang, Kim, Jiseon, Lee, Jee-Hyun, Cho, Jung-Hyun, Chun, Ho-Young, Park, Soyoung, Park, Hyunchul, Lim, Sikeun, Ha, Nam-Chul, Park, Jong Sook, Park, Choon-Sik, Song, Gyu-Yong, Park, Bum-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Disease Progression Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Genes, Tumor Suppressor Humans Immunohistochemistry Immunoprecipitation Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Inbred C57BL Mice, Transgenic Nuclear Proteins - metabolism Oncogene Proteins - metabolism Polymerase Chain Reaction Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology
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