STAT3 selectively interacts with Smad3 to antagonize TGF-β

Smad and STAT proteins are critical signal transducers and transcription factors in controlling cell growth and tumorigenesis. Here we report that the STAT3 signaling pathway attenuates transforming growth factor-β (TGF-β)-induced responses through a direct Smad3–STAT3 interplay. Activated STAT3 blu...

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Veröffentlicht in:	Oncogene 2016-08, Vol.35 (33), p.4388-4398
Hauptverfasser:	Wang, G, Yu, Y, Sun, C, Liu, T, Liang, T, Zhan, L, Lin, X, Feng, X-H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/80/86 96 Apoptosis Cell Biology Cell cycle Deoxyribonucleic acid DNA Human Genetics Internal Medicine Kinases Medicine Medicine & Public Health Mesenchyme Oncology original-article Signal transduction Smad protein Smad3 protein Smad4 protein Stat3 protein Transcription factors Transforming growth factor-b Tumorigenesis
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