Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study
Purpose The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs). Methods A cross-sectional study of 383 residents from six Australian RACFs wa...
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| Veröffentlicht in: | European journal of clinical pharmacology 2016-09, Vol.72 (9), p.1117-1124 |
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| container_title | European journal of clinical pharmacology |
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| creator | Lalic, Samanta Jamsen, Kris M. Wimmer, Barbara C. Tan, Edwin C.K. Hilmer, Sarah N. Robson, Leonie Emery, Tina Bell, J. Simon |
| description | Purpose
The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs).
Methods
A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer’s disease (QoL-AD) scale. Covariates included age, sex, Charlson’s comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2).
Results
The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4–113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate −0.02; 95 % confidence interval (CI) −0.165, 0.124;
p
= 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate −0.0009, 95 % CI −0.005, 0.003;
p
= 0.63).
Conclusions
These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time. |
| doi_str_mv | 10.1007/s00228-016-2075-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1815702894</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4144310521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-ce639bbb137194bf66e14cf77f543ef79cd807f84ec1a6c17ff9f8a9e4ae45dd3</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EokvhAbggS1y4BGYcJ465oYoWpEpwgHPkdcZbV0m8tR3BPhTviLNbEEJC4mTL8803tn_GniO8RgD1JgEI0VWAbSVANZV8wDYoa1EhSHzINgA1Vq1WcMaepHQLgI2G-jE7E0o0WLewYT8-h_GwvzFxMvbAzTzwiQZvTfZh5pF2fqKZ2zDtR_rucyESd8bmEFPZpmC9yTTwbz7f8JSNc9zPLhTZnHk8lu4WM66NwfHROyr1ok1-oDmn9dDsCmRNpNXrC-opveWG2xhSqhLZ9SZmLPZlODxlj5wZEz27X8_Z18v3Xy4-VNefrj5evLuurIQmV5baWm-3W6wVarl1bUsorVPKNbImp7QdOlCuk2TRtBaVc9p1RpM0JJthqM_Zq5N3H8PdQin3k0-WxtHMFJbUY4eNAtFp-T8oCt3WUhf05V_obVhiedyRgrZBoVYhnqjjD0Ry_T76ycRDj9Cvsfen2PsSe7_G3q89L-7Ny7bk97vjV84FECcgldK8o_jH6H9afwL4C7ur</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1810651274</pqid></control><display><type>article</type><title>Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Lalic, Samanta ; Jamsen, Kris M. ; Wimmer, Barbara C. ; Tan, Edwin C.K. ; Hilmer, Sarah N. ; Robson, Leonie ; Emery, Tina ; Bell, J. Simon</creator><creatorcontrib>Lalic, Samanta ; Jamsen, Kris M. ; Wimmer, Barbara C. ; Tan, Edwin C.K. ; Hilmer, Sarah N. ; Robson, Leonie ; Emery, Tina ; Bell, J. Simon</creatorcontrib><description>Purpose
The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs).
Methods
A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer’s disease (QoL-AD) scale. Covariates included age, sex, Charlson’s comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2).
Results
The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4–113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate −0.02; 95 % confidence interval (CI) −0.165, 0.124;
p
= 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate −0.0009, 95 % CI −0.005, 0.003;
p
= 0.63).
Conclusions
These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-016-2075-4</identifier><identifier>PMID: 27251360</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Australia ; Biomedical and Life Sciences ; Biomedicine ; Cross-Sectional Studies ; Drug therapy ; Drug Utilization ; Female ; Homes for the Aged - statistics & numerical data ; Humans ; Male ; Nursing homes ; Older people ; Pharmacoepidemiology and Prescription ; Pharmacology ; Pharmacology/Toxicology ; Polypharmacy ; Quality of Life</subject><ispartof>European journal of clinical pharmacology, 2016-09, Vol.72 (9), p.1117-1124</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-ce639bbb137194bf66e14cf77f543ef79cd807f84ec1a6c17ff9f8a9e4ae45dd3</citedby><cites>FETCH-LOGICAL-c405t-ce639bbb137194bf66e14cf77f543ef79cd807f84ec1a6c17ff9f8a9e4ae45dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-016-2075-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-016-2075-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27251360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lalic, Samanta</creatorcontrib><creatorcontrib>Jamsen, Kris M.</creatorcontrib><creatorcontrib>Wimmer, Barbara C.</creatorcontrib><creatorcontrib>Tan, Edwin C.K.</creatorcontrib><creatorcontrib>Hilmer, Sarah N.</creatorcontrib><creatorcontrib>Robson, Leonie</creatorcontrib><creatorcontrib>Emery, Tina</creatorcontrib><creatorcontrib>Bell, J. Simon</creatorcontrib><title>Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Purpose
The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs).
Methods
A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer’s disease (QoL-AD) scale. Covariates included age, sex, Charlson’s comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2).
Results
The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4–113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate −0.02; 95 % confidence interval (CI) −0.165, 0.124;
p
= 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate −0.0009, 95 % CI −0.005, 0.003;
p
= 0.63).
Conclusions
These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Australia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cross-Sectional Studies</subject><subject>Drug therapy</subject><subject>Drug Utilization</subject><subject>Female</subject><subject>Homes for the Aged - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Nursing homes</subject><subject>Older people</subject><subject>Pharmacoepidemiology and Prescription</subject><subject>Pharmacology</subject><subject>Pharmacology/Toxicology</subject><subject>Polypharmacy</subject><subject>Quality of Life</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkcFu1DAQhi0EokvhAbggS1y4BGYcJ465oYoWpEpwgHPkdcZbV0m8tR3BPhTviLNbEEJC4mTL8803tn_GniO8RgD1JgEI0VWAbSVANZV8wDYoa1EhSHzINgA1Vq1WcMaepHQLgI2G-jE7E0o0WLewYT8-h_GwvzFxMvbAzTzwiQZvTfZh5pF2fqKZ2zDtR_rucyESd8bmEFPZpmC9yTTwbz7f8JSNc9zPLhTZnHk8lu4WM66NwfHROyr1ok1-oDmn9dDsCmRNpNXrC-opveWG2xhSqhLZ9SZmLPZlODxlj5wZEz27X8_Z18v3Xy4-VNefrj5evLuurIQmV5baWm-3W6wVarl1bUsorVPKNbImp7QdOlCuk2TRtBaVc9p1RpM0JJthqM_Zq5N3H8PdQin3k0-WxtHMFJbUY4eNAtFp-T8oCt3WUhf05V_obVhiedyRgrZBoVYhnqjjD0Ry_T76ycRDj9Cvsfen2PsSe7_G3q89L-7Ny7bk97vjV84FECcgldK8o_jH6H9afwL4C7ur</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Lalic, Samanta</creator><creator>Jamsen, Kris M.</creator><creator>Wimmer, Barbara C.</creator><creator>Tan, Edwin C.K.</creator><creator>Hilmer, Sarah N.</creator><creator>Robson, Leonie</creator><creator>Emery, Tina</creator><creator>Bell, J. Simon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160901</creationdate><title>Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study</title><author>Lalic, Samanta ; Jamsen, Kris M. ; Wimmer, Barbara C. ; Tan, Edwin C.K. ; Hilmer, Sarah N. ; Robson, Leonie ; Emery, Tina ; Bell, J. Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-ce639bbb137194bf66e14cf77f543ef79cd807f84ec1a6c17ff9f8a9e4ae45dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Australia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cross-Sectional Studies</topic><topic>Drug therapy</topic><topic>Drug Utilization</topic><topic>Female</topic><topic>Homes for the Aged - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Nursing homes</topic><topic>Older people</topic><topic>Pharmacoepidemiology and Prescription</topic><topic>Pharmacology</topic><topic>Pharmacology/Toxicology</topic><topic>Polypharmacy</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lalic, Samanta</creatorcontrib><creatorcontrib>Jamsen, Kris M.</creatorcontrib><creatorcontrib>Wimmer, Barbara C.</creatorcontrib><creatorcontrib>Tan, Edwin C.K.</creatorcontrib><creatorcontrib>Hilmer, Sarah N.</creatorcontrib><creatorcontrib>Robson, Leonie</creatorcontrib><creatorcontrib>Emery, Tina</creatorcontrib><creatorcontrib>Bell, J. 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Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>72</volume><issue>9</issue><spage>1117</spage><epage>1124</epage><pages>1117-1124</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Purpose
The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs).
Methods
A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer’s disease (QoL-AD) scale. Covariates included age, sex, Charlson’s comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2).
Results
The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4–113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate −0.02; 95 % confidence interval (CI) −0.165, 0.124;
p
= 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate −0.0009, 95 % CI −0.005, 0.003;
p
= 0.63).
Conclusions
These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27251360</pmid><doi>10.1007/s00228-016-2075-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 2016-09, Vol.72 (9), p.1117-1124 |
| issn | 0031-6970 1432-1041 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Aged, 80 and over Australia Biomedical and Life Sciences Biomedicine Cross-Sectional Studies Drug therapy Drug Utilization Female Homes for the Aged - statistics & numerical data Humans Male Nursing homes Older people Pharmacoepidemiology and Prescription Pharmacology Pharmacology/Toxicology Polypharmacy Quality of Life |
| title | Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study |
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