Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice
The use of a bioorthogonal reaction for the selective cleavage of tumor-bound antibody–drug conjugates (ADCs) would represent a powerful new tool for ADC therapy, as it would not rely on the currently used intracellular biological activation mechanisms, thereby expanding the scope to noninternalizin...
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| Veröffentlicht in: | Bioconjugate chemistry 2016-07, Vol.27 (7), p.1697-1706 |
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| container_end_page | 1706 |
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| container_issue | 7 |
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| container_title | Bioconjugate chemistry |
| container_volume | 27 |
| creator | Rossin, Raffaella van Duijnhoven, Sander M. J ten Hoeve, Wolter Janssen, Henk M Kleijn, Laurens H. J Hoeben, Freek J. M Versteegen, Ron M Robillard, Marc S |
| description | The use of a bioorthogonal reaction for the selective cleavage of tumor-bound antibody–drug conjugates (ADCs) would represent a powerful new tool for ADC therapy, as it would not rely on the currently used intracellular biological activation mechanisms, thereby expanding the scope to noninternalizing cancer targets. Here we report that the recently developed inverse-electron-demand Diels–Alder pyridazine elimination reaction can provoke rapid and self-immolative release of doxorubicin from an ADC in vitro and in tumor-bearing mice. |
| doi_str_mv | 10.1021/acs.bioconjchem.6b00231 |
| format | Article |
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| ispartof | Bioconjugate chemistry, 2016-07, Vol.27 (7), p.1697-1706 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Animals Cancer therapies Cell Line, Tumor Chemical reactions Click Chemistry Doxorubicin - chemistry Drug Liberation Female Humans Immunoconjugates - blood Immunoconjugates - chemistry Immunoconjugates - pharmacokinetics Immunoglobulins Kinetics Mice Mice, Inbred BALB C Oncology Pharmacology Pyridazines - chemistry Rodents Tumors |
| title | Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice |
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