Total synthesis, structural, and biological evaluation of stylissatin A and related analogs

The natural product cyclic peptide stylissatin A (1a) was reported to inhibit nitric oxide production in LPS‐stimulated murine macrophage RAW 264.7 cells. In the current study, solid‐phase total synthesis of stylissatin A was performed by using a safety‐catch linker and yielded the peptide with a tr...

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Veröffentlicht in:	Journal of peptide science 2016-09, Vol.22 (9), p.607-617
Hauptverfasser:	Shaheen, Farzana, Jabeen, Almas, Ashraf, Samreen, Nadeem-ul-Haque, Muhammad, Shah, Zafar Ali, Ziaee, Muhammad Asad, Dastagir, Nida, Ganesan, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Cell Proliferation - drug effects cyclic peptides Cyclization Humans inflammation interleukin 2 Interleukin-2 - antagonists & inhibitors Interleukin-2 - biosynthesis Isoleucine - chemistry Jurkat Cells Macrophages - cytology Macrophages - drug effects Macrophages - immunology Mice nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Peptides Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Phenylalanine - chemistry Polystyrenes - chemistry Proline - chemistry proline rotamers Protein Conformation reactive oxygen species solid-phase peptide synthesis Solid-Phase Synthesis Techniques - methods Stereoisomerism Structure-Activity Relationship
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