The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion

Innate immune responses by myeloid cells decisively contribute to perpetuation of central nervous system (CNS) autoimmunity and their pharmacologic modulation represents a promising strategy to prevent disease progression in Multiple Sclerosis (MS). Based on our observation that peripheral immune ce...

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Veröffentlicht in:	Acta neuropathologica 2016-09, Vol.132 (3), p.413-431
Hauptverfasser:	Hucke, Stephanie, Herold, Martin, Liebmann, Marie, Freise, Nicole, Lindner, Maren, Fleck, Ann-Katrin, Zenker, Stefanie, Thiebes, Stephanie, Fernandez-Orth, Juncal, Buck, Dorothea, Luessi, Felix, Meuth, Sven G., Zipp, Frauke, Hemmer, Bernhard, Engel, Daniel Robert, Roth, Johannes, Kuhlmann, Tanja, Wiendl, Heinz, Klotz, Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity Autoimmunity - immunology B cells Bile Deoxycholic acid Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Immunology Interleukin-10 - immunology Laboratories Ligands Liver diseases Lymphocytes Macrophages Macrophages - immunology Macrophages - metabolism Medicine Medicine & Public Health Mice, Inbred C57BL Multiple sclerosis Myeloid Cells - metabolism Nervous system Neurology Neurosciences Original Paper Paresis Pathogenesis Pathology Receptors, Cytoplasmic and Nuclear - immunology T cells T-Lymphocytes - cytology T-Lymphocytes - metabolism Type 2 diabetes
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