Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitis
Background/purpose The risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) have been widely investigated. However, studies focusing on the body mass index (BMI) and distribution of adipose tissue have not been reported. Therefore, we examined the correlation betwe...
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| Veröffentlicht in: | Journal of gastroenterology 2016-09, Vol.51 (9), p.931-938 |
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| creator | Fujisawa, Toshio Kagawa, Koichi Hisatomi, Kantaro Kubota, Kensuke Sato, Hajime Nakajima, Atsushi Matsuhashi, Nobuyuki |
| description | Background/purpose
The risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) have been widely investigated. However, studies focusing on the body mass index (BMI) and distribution of adipose tissue have not been reported. Therefore, we examined the correlation between PEP and these factors.
Methods
A total of 583 consecutive endoscopic retrograde cholangiopancreatography (ERCP)-naïve patients undergoing therapeutic ERCP were retrospectively analyzed. Subjects were categorized into four groups by BMI: underweight, normal, overweight, and obesity; the PEP rates were compared. In addition, the relationship between PEP and parameters of obesity, visceral and subcutaneous adipose tissue as well as abdominal circumference was investigated.
Results
PEP rate was significantly higher in obesity (30 %) and lower in normal (3 %,
P
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| doi_str_mv | 10.1007/s00535-016-1160-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1815699568</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1815699568</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-237d5a7ad590a11bee744be7b9cb6398a0aea70aa71b2a1862dce08b94f3653c3</originalsourceid><addsrcrecordid>eNqN0VFLHDEQB_BQKvWq_QB9KYG--LJtkt1sksdyWFsQLKKvhsnuXI292z0zWarf3pxrSxGEPgVmfjNh-DP2XopPUgjzmYTQta6EbCspW1HdvWIL2ZSKdkq9ZgvhmqZ0TLPP3hLdCCFroe0btq9a45SxdsGuzgJSzPf8d8zXHMI09DBkTlPopgwDjhNx6ON2JOQ5Ek3I49AlBELi-Rp5ivSLjyteRK6Oz5c_-BYeQY7FH7K9FawJ3z29B-zy6_HF8lt1enbyffnltOoa5XKlatNrMNBrJ0DKgGiaJqAJrgtt7SwIQDACwMigQNpW9R0KG1yzqltdd_UBO5r3btN4OyFlv4nU4Xo9n-Cllbp1Trf2f6iyVhVf6Mdn9Gac0lAOeVS101rulJxVl0aihCu_TXED6d5L4Xc5-TknX3Lyu5z8XZn58LR5Chvs_078CaYANQMqreEnpn--fnHrA5pOnk8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1812395516</pqid></control><display><type>article</type><title>Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitis</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Fujisawa, Toshio ; Kagawa, Koichi ; Hisatomi, Kantaro ; Kubota, Kensuke ; Sato, Hajime ; Nakajima, Atsushi ; Matsuhashi, Nobuyuki</creator><creatorcontrib>Fujisawa, Toshio ; Kagawa, Koichi ; Hisatomi, Kantaro ; Kubota, Kensuke ; Sato, Hajime ; Nakajima, Atsushi ; Matsuhashi, Nobuyuki</creatorcontrib><description>Background/purpose
The risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) have been widely investigated. However, studies focusing on the body mass index (BMI) and distribution of adipose tissue have not been reported. Therefore, we examined the correlation between PEP and these factors.
Methods
A total of 583 consecutive endoscopic retrograde cholangiopancreatography (ERCP)-naïve patients undergoing therapeutic ERCP were retrospectively analyzed. Subjects were categorized into four groups by BMI: underweight, normal, overweight, and obesity; the PEP rates were compared. In addition, the relationship between PEP and parameters of obesity, visceral and subcutaneous adipose tissue as well as abdominal circumference was investigated.
Results
PEP rate was significantly higher in obesity (30 %) and lower in normal (3 %,
P
< 0.001). The PEP rate in underweight (7.3 %) was conversely higher than in normal. As for parameters of obesity, only subcutaneous adipose tissue was correlated with PEP incidence (
P
= 0.009). The correlation of PEP incidence with BMI and subcutaneous adipose tissue was separately reconfirmed by multivariate analysis including female gender and guidewire placement; these factors showed a tendency toward differences in univariate analysis.
Conclusions
Obesity could be a risk factor for PEP. In the obesity group, an excess of subcutaneous adipose tissue might be an especially important factor related to PEP incidence.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-016-1160-x</identifier><identifier>PMID: 26792788</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Biliary Tract ; Body fat ; Body Fat Distribution ; Cholangiopancreatography, Endoscopic Retrograde - adverse effects ; Colorectal Surgery ; Female ; Gastroenterology ; Hepatology ; Humans ; Incidence ; Intra-Abdominal Fat ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Obesity - complications ; Obesity - pathology ; Original Article—Liver ; Pancreas ; Pancreatitis - epidemiology ; Pancreatitis - etiology ; Retrospective Studies ; Risk Factors ; Subcutaneous Fat ; Surgical Oncology ; Waist Circumference</subject><ispartof>Journal of gastroenterology, 2016-09, Vol.51 (9), p.931-938</ispartof><rights>Japanese Society of Gastroenterology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-237d5a7ad590a11bee744be7b9cb6398a0aea70aa71b2a1862dce08b94f3653c3</citedby><cites>FETCH-LOGICAL-c429t-237d5a7ad590a11bee744be7b9cb6398a0aea70aa71b2a1862dce08b94f3653c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-016-1160-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-016-1160-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26792788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujisawa, Toshio</creatorcontrib><creatorcontrib>Kagawa, Koichi</creatorcontrib><creatorcontrib>Hisatomi, Kantaro</creatorcontrib><creatorcontrib>Kubota, Kensuke</creatorcontrib><creatorcontrib>Sato, Hajime</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Matsuhashi, Nobuyuki</creatorcontrib><title>Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitis</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background/purpose
The risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) have been widely investigated. However, studies focusing on the body mass index (BMI) and distribution of adipose tissue have not been reported. Therefore, we examined the correlation between PEP and these factors.
Methods
A total of 583 consecutive endoscopic retrograde cholangiopancreatography (ERCP)-naïve patients undergoing therapeutic ERCP were retrospectively analyzed. Subjects were categorized into four groups by BMI: underweight, normal, overweight, and obesity; the PEP rates were compared. In addition, the relationship between PEP and parameters of obesity, visceral and subcutaneous adipose tissue as well as abdominal circumference was investigated.
Results
PEP rate was significantly higher in obesity (30 %) and lower in normal (3 %,
P
< 0.001). The PEP rate in underweight (7.3 %) was conversely higher than in normal. As for parameters of obesity, only subcutaneous adipose tissue was correlated with PEP incidence (
P
= 0.009). The correlation of PEP incidence with BMI and subcutaneous adipose tissue was separately reconfirmed by multivariate analysis including female gender and guidewire placement; these factors showed a tendency toward differences in univariate analysis.
Conclusions
Obesity could be a risk factor for PEP. In the obesity group, an excess of subcutaneous adipose tissue might be an especially important factor related to PEP incidence.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biliary Tract</subject><subject>Body fat</subject><subject>Body Fat Distribution</subject><subject>Cholangiopancreatography, Endoscopic Retrograde - adverse effects</subject><subject>Colorectal Surgery</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intra-Abdominal Fat</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity - complications</subject><subject>Obesity - pathology</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>Pancreatitis - epidemiology</subject><subject>Pancreatitis - etiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Subcutaneous Fat</subject><subject>Surgical Oncology</subject><subject>Waist Circumference</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqN0VFLHDEQB_BQKvWq_QB9KYG--LJtkt1sksdyWFsQLKKvhsnuXI292z0zWarf3pxrSxGEPgVmfjNh-DP2XopPUgjzmYTQta6EbCspW1HdvWIL2ZSKdkq9ZgvhmqZ0TLPP3hLdCCFroe0btq9a45SxdsGuzgJSzPf8d8zXHMI09DBkTlPopgwDjhNx6ON2JOQ5Ek3I49AlBELi-Rp5ivSLjyteRK6Oz5c_-BYeQY7FH7K9FawJ3z29B-zy6_HF8lt1enbyffnltOoa5XKlatNrMNBrJ0DKgGiaJqAJrgtt7SwIQDACwMigQNpW9R0KG1yzqltdd_UBO5r3btN4OyFlv4nU4Xo9n-Cllbp1Trf2f6iyVhVf6Mdn9Gac0lAOeVS101rulJxVl0aihCu_TXED6d5L4Xc5-TknX3Lyu5z8XZn58LR5Chvs_078CaYANQMqreEnpn--fnHrA5pOnk8</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Fujisawa, Toshio</creator><creator>Kagawa, Koichi</creator><creator>Hisatomi, Kantaro</creator><creator>Kubota, Kensuke</creator><creator>Sato, Hajime</creator><creator>Nakajima, Atsushi</creator><creator>Matsuhashi, Nobuyuki</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitis</title><author>Fujisawa, Toshio ; Kagawa, Koichi ; Hisatomi, Kantaro ; Kubota, Kensuke ; Sato, Hajime ; Nakajima, Atsushi ; Matsuhashi, Nobuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-237d5a7ad590a11bee744be7b9cb6398a0aea70aa71b2a1862dce08b94f3653c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biliary Tract</topic><topic>Body fat</topic><topic>Body Fat Distribution</topic><topic>Cholangiopancreatography, Endoscopic Retrograde - adverse effects</topic><topic>Colorectal Surgery</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intra-Abdominal Fat</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity - complications</topic><topic>Obesity - pathology</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>Pancreatitis - epidemiology</topic><topic>Pancreatitis - etiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Subcutaneous Fat</topic><topic>Surgical Oncology</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujisawa, Toshio</creatorcontrib><creatorcontrib>Kagawa, Koichi</creatorcontrib><creatorcontrib>Hisatomi, Kantaro</creatorcontrib><creatorcontrib>Kubota, Kensuke</creatorcontrib><creatorcontrib>Sato, Hajime</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Matsuhashi, Nobuyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujisawa, Toshio</au><au>Kagawa, Koichi</au><au>Hisatomi, Kantaro</au><au>Kubota, Kensuke</au><au>Sato, Hajime</au><au>Nakajima, Atsushi</au><au>Matsuhashi, Nobuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitis</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>51</volume><issue>9</issue><spage>931</spage><epage>938</epage><pages>931-938</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background/purpose
The risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) have been widely investigated. However, studies focusing on the body mass index (BMI) and distribution of adipose tissue have not been reported. Therefore, we examined the correlation between PEP and these factors.
Methods
A total of 583 consecutive endoscopic retrograde cholangiopancreatography (ERCP)-naïve patients undergoing therapeutic ERCP were retrospectively analyzed. Subjects were categorized into four groups by BMI: underweight, normal, overweight, and obesity; the PEP rates were compared. In addition, the relationship between PEP and parameters of obesity, visceral and subcutaneous adipose tissue as well as abdominal circumference was investigated.
Results
PEP rate was significantly higher in obesity (30 %) and lower in normal (3 %,
P
< 0.001). The PEP rate in underweight (7.3 %) was conversely higher than in normal. As for parameters of obesity, only subcutaneous adipose tissue was correlated with PEP incidence (
P
= 0.009). The correlation of PEP incidence with BMI and subcutaneous adipose tissue was separately reconfirmed by multivariate analysis including female gender and guidewire placement; these factors showed a tendency toward differences in univariate analysis.
Conclusions
Obesity could be a risk factor for PEP. In the obesity group, an excess of subcutaneous adipose tissue might be an especially important factor related to PEP incidence.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26792788</pmid><doi>10.1007/s00535-016-1160-x</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Biliary Tract Body fat Body Fat Distribution Cholangiopancreatography, Endoscopic Retrograde - adverse effects Colorectal Surgery Female Gastroenterology Hepatology Humans Incidence Intra-Abdominal Fat Logistic Models Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Obesity - complications Obesity - pathology Original Article—Liver Pancreas Pancreatitis - epidemiology Pancreatitis - etiology Retrospective Studies Risk Factors Subcutaneous Fat Surgical Oncology Waist Circumference |
| title | Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitis |
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