CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression
Major histocompatibility complex (MHC) class I and class II molecules play essential roles in the development and activation of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator) has been recognized as a master regulator of MHC class II gene expression, albeit know...
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| Veröffentlicht in: | BioFactors (Oxford) 2016-07, Vol.42 (4), p.349-357 |
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| creator | Downs, Isaac Vijayan, Saptha Sidiq, Tabasum Kobayashi, Koichi S. |
| description | Major histocompatibility complex (MHC) class I and class II molecules play essential roles in the development and activation of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator) has been recognized as a master regulator of MHC class II gene expression, albeit knowledge about the regulatory mechanism of MHC class I gene expression had been limited. Recently identified MHC class I transactivator (CITA), or NLRC5, also belongs to the NLR protein family and constitutes a critical regulator for the transcriptional activation of MHC class I genes. In addition to MHC class I genes, CITA/NLRC5 induces the expression of β2‐microglobulin, TAP1 and LMP2, essential components of the MHC class I antigen presentation pathway. Therefore, CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. © 2016 BioFactors, 42(4):349–357, 2016 |
| doi_str_mv | 10.1002/biof.1285 |
| format | Article |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals CIITA Gene Expression Gene Expression Regulation Genes, MHC Class I Humans Intracellular Signaling Peptides and Proteins - physiology MHC class I NLR proteins NLRC5 |
| title | CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression |
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