Pan‐HER—An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand‐induced EGFR homo‐ and heterodimers

The human epidermal growth factor receptor (HER)‐family is involved in development of many epithelial cancers. Therefore, HER‐family members constitute important targets for anti‐cancer therapeutics such as monoclonal antibodies (mAbs). A limitation to the success of single HER‐targeting mAbs is dev...

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Veröffentlicht in:	International journal of cancer 2016-11, Vol.139 (9), p.2095-2105
Hauptverfasser:	Ellebæk, Sofie, Brix, Susanne, Grandal, Michael, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Poulsen, Thomas Tuxen
Format:	Artikel
Sprache:	eng
Schlagworte:	antibodies Antibodies, Monoclonal, Humanized - pharmacology Cancer Cancer therapies Cell Line, Tumor Cell Proliferation - drug effects Dimerization Drug resistance Drug Resistance, Neoplasm - drug effects EGFR Epidermal growth factor Gene Expression Regulation, Neoplastic HER‐family Humans Immunoglobulins Ligands Medical research Neoplasms - chemistry Neoplasms - drug therapy Neoplasms - metabolism Protein Binding - drug effects Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - chemistry Receptor, ErbB-3 - metabolism
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