Interferon-induced sterile alpha motif and histidine/aspartic acid domain-containing protein 1 expression in astrocytes and microglia is mediated by microRNA-181a

OBJECTIVE:Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1), a newly discovered HIV-1 host restriction factor, has been found to be induced by interferons and to be regulated by microRNA-181a (miR-181a). However, the mechanism of interferons-induced SAMHD1 expressi...

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Veröffentlicht in:	AIDS (London) 2016-08, Vol.30 (13), p.2053-2064
Hauptverfasser:	Jin, Changzhong, Peng, Xiaorong, Liu, Fumin, Cheng, Linfang, Xie, Tiansheng, Lu, Xiangyun, Wu, Haibo, Wu, Nanping
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Astrocytes - immunology Cells, Cultured Gene Expression Profiling Gene Expression Regulation Human immunodeficiency virus 1 Humans Interferons - metabolism Lentivirus Microglia - immunology MicroRNAs - metabolism SAM Domain and HD Domain-Containing Protein 1 - biosynthesis Signal Transduction
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