HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors
Pheochromocytomas and paragangliomas are rare, neural crest‐originating, neuroendocrine tumors. HuR is an mRNA‐binding protein of the ELAV/Hu‐protein family, which participates in posttranscriptional regulation of many cancer‐associated genes. HuR expression has been connected with aggressive behavi...
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| Veröffentlicht in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2016-09, Vol.124 (9), p.757-763 |
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| creator | Leijon, Helena Salmenkivi, Kaisa Heiskanen, Ilkka Hagström, Jaana Louhimo, Johanna Heikkilä, Päivi Ristimäki, Ari Paavonen, Timo Metso, Saara Mäenpää, Hanna Haglund, Caj Arola, Johanna |
| description | Pheochromocytomas and paragangliomas are rare, neural crest‐originating, neuroendocrine tumors. HuR is an mRNA‐binding protein of the ELAV/Hu‐protein family, which participates in posttranscriptional regulation of many cancer‐associated genes. HuR expression has been connected with aggressive behavior of several malignancies. Cyclooxygenase‐2 (COX‐2) is also expressed in several malignant tumors, and its expression is regulated by HuR. Tissue microarray of 153 primary pheochromocytomas and paragangliomas was investigated for the expression of HuR and COX‐2 proteins by immunohistochemistry using two different HuR antibodies (HuR19F12 and HuR3A). In these tumors, the expression of both intranuclear and cytoplasmic HuR was detectable. Increased cytoplasmic HuR expression was significantly associated with metastatic tumors. Increased COX‐2 and MIB‐1 expression also was associated with metastatic potential, and moreover, HuR and COX‐2 expression correlated with each other. Our data suggest that increased expression of HuR protein is associated with metastatic potential of paragangliomas and pheochromocytomas, and COX‐2 seems to be a target of HuR. |
| doi_str_mv | 10.1111/apm.12571 |
| format | Article |
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HuR is an mRNA‐binding protein of the ELAV/Hu‐protein family, which participates in posttranscriptional regulation of many cancer‐associated genes. HuR expression has been connected with aggressive behavior of several malignancies. Cyclooxygenase‐2 (COX‐2) is also expressed in several malignant tumors, and its expression is regulated by HuR. Tissue microarray of 153 primary pheochromocytomas and paragangliomas was investigated for the expression of HuR and COX‐2 proteins by immunohistochemistry using two different HuR antibodies (HuR19F12 and HuR3A). In these tumors, the expression of both intranuclear and cytoplasmic HuR was detectable. Increased cytoplasmic HuR expression was significantly associated with metastatic tumors. Increased COX‐2 and MIB‐1 expression also was associated with metastatic potential, and moreover, HuR and COX‐2 expression correlated with each other. Our data suggest that increased expression of HuR protein is associated with metastatic potential of paragangliomas and pheochromocytomas, and COX‐2 seems to be a target of HuR.</description><identifier>ISSN: 0903-4641</identifier><identifier>EISSN: 1600-0463</identifier><identifier>DOI: 10.1111/apm.12571</identifier><identifier>PMID: 27357268</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Cell Nucleus - chemistry ; Cyclooxygenase 2 - analysis ; Cytoplasm - chemistry ; ELAV-Like Protein 1 - analysis ; Gene Expression ; Gene Expression Profiling ; Humans ; HuR ; Immunohistochemistry ; Metastasis ; Microarray Analysis ; Neoplasm Metastasis - pathology ; paraganglioma ; Paraganglioma - pathology ; Paraganglioma - secondary ; pheochromocytoma ; Pheochromocytoma - pathology ; Pheochromocytoma - secondary ; Proteins ; Tumors</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2016-09, Vol.124 (9), p.757-763</ispartof><rights>2016 APMIS. 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HuR is an mRNA‐binding protein of the ELAV/Hu‐protein family, which participates in posttranscriptional regulation of many cancer‐associated genes. HuR expression has been connected with aggressive behavior of several malignancies. Cyclooxygenase‐2 (COX‐2) is also expressed in several malignant tumors, and its expression is regulated by HuR. Tissue microarray of 153 primary pheochromocytomas and paragangliomas was investigated for the expression of HuR and COX‐2 proteins by immunohistochemistry using two different HuR antibodies (HuR19F12 and HuR3A). In these tumors, the expression of both intranuclear and cytoplasmic HuR was detectable. Increased cytoplasmic HuR expression was significantly associated with metastatic tumors. Increased COX‐2 and MIB‐1 expression also was associated with metastatic potential, and moreover, HuR and COX‐2 expression correlated with each other. Our data suggest that increased expression of HuR protein is associated with metastatic potential of paragangliomas and pheochromocytomas, and COX‐2 seems to be a target of HuR.</description><subject>Cell Nucleus - chemistry</subject><subject>Cyclooxygenase 2 - analysis</subject><subject>Cytoplasm - chemistry</subject><subject>ELAV-Like Protein 1 - analysis</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>HuR</subject><subject>Immunohistochemistry</subject><subject>Metastasis</subject><subject>Microarray Analysis</subject><subject>Neoplasm Metastasis - pathology</subject><subject>paraganglioma</subject><subject>Paraganglioma - pathology</subject><subject>Paraganglioma - secondary</subject><subject>pheochromocytoma</subject><subject>Pheochromocytoma - pathology</subject><subject>Pheochromocytoma - secondary</subject><subject>Proteins</subject><subject>Tumors</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EotuFA18AReJCD2nH_5NjW2CLaAtCIMTJcmJ765LEwU6g--3xdtsekJCYy0ij33vSvIfQCwyHOM-RHvtDTLjEj9ACC4ASmKCP0QJqoCUTDO-h_ZSuATCphHyK9oikXBJRLdD3s_lz4YdivLKhvYqhD-1mCr1OhR5MMeqo13pYd_72VBbhl432Zow2JR-GrTAfvPPWFL3u_HrQw1RMcx9ieoaeON0l-_xuL9HXd2-_nJ6V5x9X70-Pz8uW1QyXtGkAuDPYUAJOOOYcCEobqhmvOKsNaCOIZBURBpipHTNN2wDltZSWGE2X6PXOd4zh52zTpHqfWtt1erBhTgpXmIua44r_D0oFyaHVGX31F3od5jjkR7YUqRjIHOISHeyoNoaUonVqjL7XcaMwqG01KlejbqvJ7Ms7x7nprXkg77vIwNEO-O07u_m3kzr-dHFvWe4UPk325kGh4w8lJJVcfbtcqQ8X-anVm0t1Qv8AsGOmSw</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Leijon, Helena</creator><creator>Salmenkivi, Kaisa</creator><creator>Heiskanen, Ilkka</creator><creator>Hagström, Jaana</creator><creator>Louhimo, Johanna</creator><creator>Heikkilä, Päivi</creator><creator>Ristimäki, Ari</creator><creator>Paavonen, Timo</creator><creator>Metso, Saara</creator><creator>Mäenpää, Hanna</creator><creator>Haglund, Caj</creator><creator>Arola, Johanna</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors</title><author>Leijon, Helena ; Salmenkivi, Kaisa ; Heiskanen, Ilkka ; Hagström, Jaana ; Louhimo, Johanna ; Heikkilä, Päivi ; Ristimäki, Ari ; Paavonen, Timo ; Metso, Saara ; Mäenpää, Hanna ; Haglund, Caj ; Arola, Johanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4941-3bb005fd1d320f6f4ff0633b3a458549d0ad6274826d04d9f4dbcb035977e2da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cell Nucleus - chemistry</topic><topic>Cyclooxygenase 2 - analysis</topic><topic>Cytoplasm - chemistry</topic><topic>ELAV-Like Protein 1 - analysis</topic><topic>Gene Expression</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>HuR</topic><topic>Immunohistochemistry</topic><topic>Metastasis</topic><topic>Microarray Analysis</topic><topic>Neoplasm Metastasis - pathology</topic><topic>paraganglioma</topic><topic>Paraganglioma - pathology</topic><topic>Paraganglioma - secondary</topic><topic>pheochromocytoma</topic><topic>Pheochromocytoma - pathology</topic><topic>Pheochromocytoma - secondary</topic><topic>Proteins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leijon, Helena</creatorcontrib><creatorcontrib>Salmenkivi, Kaisa</creatorcontrib><creatorcontrib>Heiskanen, Ilkka</creatorcontrib><creatorcontrib>Hagström, Jaana</creatorcontrib><creatorcontrib>Louhimo, Johanna</creatorcontrib><creatorcontrib>Heikkilä, Päivi</creatorcontrib><creatorcontrib>Ristimäki, Ari</creatorcontrib><creatorcontrib>Paavonen, Timo</creatorcontrib><creatorcontrib>Metso, Saara</creatorcontrib><creatorcontrib>Mäenpää, Hanna</creatorcontrib><creatorcontrib>Haglund, Caj</creatorcontrib><creatorcontrib>Arola, Johanna</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leijon, Helena</au><au>Salmenkivi, Kaisa</au><au>Heiskanen, Ilkka</au><au>Hagström, Jaana</au><au>Louhimo, Johanna</au><au>Heikkilä, Päivi</au><au>Ristimäki, Ari</au><au>Paavonen, Timo</au><au>Metso, Saara</au><au>Mäenpää, Hanna</au><au>Haglund, Caj</au><au>Arola, Johanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2016-09</date><risdate>2016</risdate><volume>124</volume><issue>9</issue><spage>757</spage><epage>763</epage><pages>757-763</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>Pheochromocytomas and paragangliomas are rare, neural crest‐originating, neuroendocrine tumors. HuR is an mRNA‐binding protein of the ELAV/Hu‐protein family, which participates in posttranscriptional regulation of many cancer‐associated genes. HuR expression has been connected with aggressive behavior of several malignancies. Cyclooxygenase‐2 (COX‐2) is also expressed in several malignant tumors, and its expression is regulated by HuR. Tissue microarray of 153 primary pheochromocytomas and paragangliomas was investigated for the expression of HuR and COX‐2 proteins by immunohistochemistry using two different HuR antibodies (HuR19F12 and HuR3A). In these tumors, the expression of both intranuclear and cytoplasmic HuR was detectable. Increased cytoplasmic HuR expression was significantly associated with metastatic tumors. Increased COX‐2 and MIB‐1 expression also was associated with metastatic potential, and moreover, HuR and COX‐2 expression correlated with each other. Our data suggest that increased expression of HuR protein is associated with metastatic potential of paragangliomas and pheochromocytomas, and COX‐2 seems to be a target of HuR.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>27357268</pmid><doi>10.1111/apm.12571</doi><tpages>7</tpages></addata></record> |
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| subjects | Cell Nucleus - chemistry Cyclooxygenase 2 - analysis Cytoplasm - chemistry ELAV-Like Protein 1 - analysis Gene Expression Gene Expression Profiling Humans HuR Immunohistochemistry Metastasis Microarray Analysis Neoplasm Metastasis - pathology paraganglioma Paraganglioma - pathology Paraganglioma - secondary pheochromocytoma Pheochromocytoma - pathology Pheochromocytoma - secondary Proteins Tumors |
| title | HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors |
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