Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study
Summary Context In observational studies, low serum 25‐hydroxyvitamin D (25‐OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25‐OHD may have beneficial effects on insulin resistance or beta‐cell function. Cross‐sectional studies utilizing sub...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2016-09, Vol.85 (3), p.386-392 |
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| creator | Wallace, I.R. McKinley, M.C. McEvoy, C.T. Hamill, L.L. Ennis, C.N. McGinty, A. Bell, P.M. Patterson, C.C. Woodside, J.V. Young, I.S. Hunter, S.J. |
| description | Summary
Context
In observational studies, low serum 25‐hydroxyvitamin D (25‐OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25‐OHD may have beneficial effects on insulin resistance or beta‐cell function. Cross‐sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25‐OHD concentration provide conflicting results.
Objective
This study examined the relationship between serum 25‐OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques.
Methods
A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m2), underwent assessments of insulin sensitivity (two‐step euglycaemic hyperinsulinaemic clamp, HOMA2‐IR), beta‐cell function (HOMA2%B), serum 25‐OHD concentration and body composition (DEXA).
Results
Mean total 25‐OHD concentration was 32·2, range 21·8–46·6 nmol/l. No association was demonstrated between serum 25‐OHD concentration and insulin resistance.
Conclusions
In this study using optimal assessment techniques to measure 25‐OHD concentration, insulin sensitivity and body composition, there was no association between serum 25‐OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25‐OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25‐OHD concentration and insulin resistance. |
| doi_str_mv | 10.1111/cen.13100 |
| format | Article |
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Context
In observational studies, low serum 25‐hydroxyvitamin D (25‐OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25‐OHD may have beneficial effects on insulin resistance or beta‐cell function. Cross‐sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25‐OHD concentration provide conflicting results.
Objective
This study examined the relationship between serum 25‐OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques.
Methods
A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m2), underwent assessments of insulin sensitivity (two‐step euglycaemic hyperinsulinaemic clamp, HOMA2‐IR), beta‐cell function (HOMA2%B), serum 25‐OHD concentration and body composition (DEXA).
Results
Mean total 25‐OHD concentration was 32·2, range 21·8–46·6 nmol/l. No association was demonstrated between serum 25‐OHD concentration and insulin resistance.
Conclusions
In this study using optimal assessment techniques to measure 25‐OHD concentration, insulin sensitivity and body composition, there was no association between serum 25‐OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25‐OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25‐OHD concentration and insulin resistance.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.13100</identifier><identifier>PMID: 27175553</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Cardiovascular Diseases ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; Humans ; Insulin Resistance ; Middle Aged ; Overweight ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Clinical endocrinology (Oxford), 2016-09, Vol.85 (3), p.386-392</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4590-7fbd449c5879d0608b06c8cda9db42449219538cec9f2bdc00687e3f23a3c87d3</citedby><cites>FETCH-LOGICAL-c4590-7fbd449c5879d0608b06c8cda9db42449219538cec9f2bdc00687e3f23a3c87d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.13100$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.13100$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27175553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallace, I.R.</creatorcontrib><creatorcontrib>McKinley, M.C.</creatorcontrib><creatorcontrib>McEvoy, C.T.</creatorcontrib><creatorcontrib>Hamill, L.L.</creatorcontrib><creatorcontrib>Ennis, C.N.</creatorcontrib><creatorcontrib>McGinty, A.</creatorcontrib><creatorcontrib>Bell, P.M.</creatorcontrib><creatorcontrib>Patterson, C.C.</creatorcontrib><creatorcontrib>Woodside, J.V.</creatorcontrib><creatorcontrib>Young, I.S.</creatorcontrib><creatorcontrib>Hunter, S.J.</creatorcontrib><title>Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Context
In observational studies, low serum 25‐hydroxyvitamin D (25‐OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25‐OHD may have beneficial effects on insulin resistance or beta‐cell function. Cross‐sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25‐OHD concentration provide conflicting results.
Objective
This study examined the relationship between serum 25‐OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques.
Methods
A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m2), underwent assessments of insulin sensitivity (two‐step euglycaemic hyperinsulinaemic clamp, HOMA2‐IR), beta‐cell function (HOMA2%B), serum 25‐OHD concentration and body composition (DEXA).
Results
Mean total 25‐OHD concentration was 32·2, range 21·8–46·6 nmol/l. No association was demonstrated between serum 25‐OHD concentration and insulin resistance.
Conclusions
In this study using optimal assessment techniques to measure 25‐OHD concentration, insulin sensitivity and body composition, there was no association between serum 25‐OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25‐OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25‐OHD concentration and insulin resistance.</description><subject>Cardiovascular Diseases</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Middle Aged</subject><subject>Overweight</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCgT-ALHGBQ9pxHMcJt2ppF6SlgPg6Wl570nWbL-ykNH-C34yXbHtAQsKXkWeeeSzrJeQZg2MWz4nB9phxBvCALBjPRZKmuXhIFsABEsjz7IAchnAFAKIA-ZgcpJJJIQRfkF-f0Y8NTUWynazvbqcbN-jGtfQN1a2lrg1jHW8egwuDbg3GFu2x62ukeqBbd7ml3oVr2lXUaG9dd6ODGWvtqXUBdcDXVFMcL-vJaGycodupR7_3zh1T66anYRjt9IQ8qnQd8Om-HpGv52dflm-T9YfVu-XpOjGZKCGR1cZmWWlEIUsLORQbyE1hrC7tJkvjJGWl4IVBU1bpxhqAvJDIq5Rrbgpp-RF5OXt73_0YMQyqccFgXesWuzEoVjCRlwIy-B80vshKlkb0xV_oVTf6Nn5kR0Ujl8VO-GqmjO9C8Fip3rtG-0kxULs8VcxT_ckzss_3xnHToL0n7wKMwMkM_HQ1Tv82qeXZxZ0ymTdioHh7v6H9tcoll0J9v1ip7OP6fVauvqlP_DdmNLmH</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Wallace, I.R.</creator><creator>McKinley, M.C.</creator><creator>McEvoy, C.T.</creator><creator>Hamill, L.L.</creator><creator>Ennis, C.N.</creator><creator>McGinty, A.</creator><creator>Bell, P.M.</creator><creator>Patterson, C.C.</creator><creator>Woodside, J.V.</creator><creator>Young, I.S.</creator><creator>Hunter, S.J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study</title><author>Wallace, I.R. ; McKinley, M.C. ; McEvoy, C.T. ; Hamill, L.L. ; Ennis, C.N. ; McGinty, A. ; Bell, P.M. ; Patterson, C.C. ; Woodside, J.V. ; Young, I.S. ; Hunter, S.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4590-7fbd449c5879d0608b06c8cda9db42449219538cec9f2bdc00687e3f23a3c87d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular Diseases</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Middle Aged</topic><topic>Overweight</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, I.R.</creatorcontrib><creatorcontrib>McKinley, M.C.</creatorcontrib><creatorcontrib>McEvoy, C.T.</creatorcontrib><creatorcontrib>Hamill, L.L.</creatorcontrib><creatorcontrib>Ennis, C.N.</creatorcontrib><creatorcontrib>McGinty, A.</creatorcontrib><creatorcontrib>Bell, P.M.</creatorcontrib><creatorcontrib>Patterson, C.C.</creatorcontrib><creatorcontrib>Woodside, J.V.</creatorcontrib><creatorcontrib>Young, I.S.</creatorcontrib><creatorcontrib>Hunter, S.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, I.R.</au><au>McKinley, M.C.</au><au>McEvoy, C.T.</au><au>Hamill, L.L.</au><au>Ennis, C.N.</au><au>McGinty, A.</au><au>Bell, P.M.</au><au>Patterson, C.C.</au><au>Woodside, J.V.</au><au>Young, I.S.</au><au>Hunter, S.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2016-09</date><risdate>2016</risdate><volume>85</volume><issue>3</issue><spage>386</spage><epage>392</epage><pages>386-392</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary
Context
In observational studies, low serum 25‐hydroxyvitamin D (25‐OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25‐OHD may have beneficial effects on insulin resistance or beta‐cell function. Cross‐sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25‐OHD concentration provide conflicting results.
Objective
This study examined the relationship between serum 25‐OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques.
Methods
A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m2), underwent assessments of insulin sensitivity (two‐step euglycaemic hyperinsulinaemic clamp, HOMA2‐IR), beta‐cell function (HOMA2%B), serum 25‐OHD concentration and body composition (DEXA).
Results
Mean total 25‐OHD concentration was 32·2, range 21·8–46·6 nmol/l. No association was demonstrated between serum 25‐OHD concentration and insulin resistance.
Conclusions
In this study using optimal assessment techniques to measure 25‐OHD concentration, insulin sensitivity and body composition, there was no association between serum 25‐OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25‐OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25‐OHD concentration and insulin resistance.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27175553</pmid><doi>10.1111/cen.13100</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2016-09, Vol.85 (3), p.386-392 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1815695040 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cardiovascular Diseases Cross-Sectional Studies Diabetes Mellitus, Type 2 Humans Insulin Resistance Middle Aged Overweight Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study |
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