Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high‐fat diet
BACKGROUND: Foods that are rich in fat and or sodium chloride promote obesity and associated diseases, whereas intake of dietary fiber averts obesity development. Salicornia herbacea (SH) is a rich source of dietary fiber and high in sodium chloride; therefore, we investigated whether replacing comm...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2015-12, Vol.95 (15), p.3150-3159 |
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| description | BACKGROUND: Foods that are rich in fat and or sodium chloride promote obesity and associated diseases, whereas intake of dietary fiber averts obesity development. Salicornia herbacea (SH) is a rich source of dietary fiber and high in sodium chloride; therefore, we investigated whether replacing common salt with SH in a high‐fat diet could prevent obesity development. RESULTS: Mice were divided into five groups: group ND was fed a normal diet, group HD was fed a high‐fat diet, group HD‐NaCl was fed a high fat diet with sodium chloride 10 g kg⁻¹, group HD‐CL was fed a high‐fat diet with cellulose 30 g kg⁻¹ and group HD‐SH was fed a high‐fat diet with SH powder 50 g kg⁻¹. The amount of sodium chloride and cellulose added in the respective diet was equivalent to their amount in SH. Data from our study showed that, SH supplementation significantly decreased body weight gain, liver weight, hepatic triglyceride, serum leptin and insulin, along with the mRNA level of key lipid anabolic genes such as SREBP‐1c, PPARγ and FAS compared to the HD group. CONCLUSION: The results of this study demonstrated that SH is a potential natural anti‐obesity agent that can be used in place of sodium chloride. © 2014 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.7054 |
| format | Article |
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Salicornia herbacea (SH) is a rich source of dietary fiber and high in sodium chloride; therefore, we investigated whether replacing common salt with SH in a high‐fat diet could prevent obesity development. RESULTS: Mice were divided into five groups: group ND was fed a normal diet, group HD was fed a high‐fat diet, group HD‐NaCl was fed a high fat diet with sodium chloride 10 g kg⁻¹, group HD‐CL was fed a high‐fat diet with cellulose 30 g kg⁻¹ and group HD‐SH was fed a high‐fat diet with SH powder 50 g kg⁻¹. The amount of sodium chloride and cellulose added in the respective diet was equivalent to their amount in SH. Data from our study showed that, SH supplementation significantly decreased body weight gain, liver weight, hepatic triglyceride, serum leptin and insulin, along with the mRNA level of key lipid anabolic genes such as SREBP‐1c, PPARγ and FAS compared to the HD group. CONCLUSION: The results of this study demonstrated that SH is a potential natural anti‐obesity agent that can be used in place of sodium chloride. © 2014 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.7054</identifier><identifier>PMID: 25523516</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>adipose tissue ; adipose tissue, leptin ; Animals ; Anti-Obesity Agents - pharmacology ; Anti-Obesity Agents - therapeutic use ; blood serum ; body weight changes ; Cellulose ; Chenopodiaceae - chemistry ; Diet ; Diet, High-Fat ; Dietary Fats - administration & dosage ; dietary fiber ; Dietary Fiber - pharmacology ; Dietary Fiber - therapeutic use ; Dietary Supplements ; Diets ; Fibers ; food intake ; Food science ; Foods ; gene expression ; genes ; high fat diet ; ICR mice ; insulin ; Insulin - blood ; leptin ; Leptin - blood ; Lipid Metabolism - genetics ; Lipids ; liver ; Liver - drug effects ; Liver - metabolism ; Male ; messenger RNA ; Mice ; Mice, Inbred ICR ; Mice, Obese ; Obesity ; Obesity - drug therapy ; Obesity - genetics ; Obesity - metabolism ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; RNA, Messenger - metabolism ; Rodents ; Salicornia europaea ; Salicornia herbacea ; Sodium chloride ; Sodium Chloride, Dietary - administration & dosage ; triacylglycerols ; Triglycerides - blood ; weight gain ; Weight Gain - drug effects</subject><ispartof>Journal of the science of food and agriculture, 2015-12, Vol.95 (15), p.3150-3159</ispartof><rights>2014 Society of Chemical Industry</rights><rights>2014 Society of Chemical Industry.</rights><rights>Copyright John Wiley and Sons, Limited Dec 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5174-efefc9a5505a786ddf28503ff47e56d31fadd6f7f9671b6a4ba12ba2a4dc4aaf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.7054$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.7054$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25523516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pichiah, PB Tirupathi</creatorcontrib><creatorcontrib>Cha, Youn‐Soo</creatorcontrib><title>Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high‐fat diet</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>BACKGROUND: Foods that are rich in fat and or sodium chloride promote obesity and associated diseases, whereas intake of dietary fiber averts obesity development. Salicornia herbacea (SH) is a rich source of dietary fiber and high in sodium chloride; therefore, we investigated whether replacing common salt with SH in a high‐fat diet could prevent obesity development. RESULTS: Mice were divided into five groups: group ND was fed a normal diet, group HD was fed a high‐fat diet, group HD‐NaCl was fed a high fat diet with sodium chloride 10 g kg⁻¹, group HD‐CL was fed a high‐fat diet with cellulose 30 g kg⁻¹ and group HD‐SH was fed a high‐fat diet with SH powder 50 g kg⁻¹. The amount of sodium chloride and cellulose added in the respective diet was equivalent to their amount in SH. Data from our study showed that, SH supplementation significantly decreased body weight gain, liver weight, hepatic triglyceride, serum leptin and insulin, along with the mRNA level of key lipid anabolic genes such as SREBP‐1c, PPARγ and FAS compared to the HD group. CONCLUSION: The results of this study demonstrated that SH is a potential natural anti‐obesity agent that can be used in place of sodium chloride. © 2014 Society of Chemical Industry</description><subject>adipose tissue</subject><subject>adipose tissue, leptin</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Anti-Obesity Agents - therapeutic use</subject><subject>blood serum</subject><subject>body weight changes</subject><subject>Cellulose</subject><subject>Chenopodiaceae - chemistry</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Dietary Fats - administration & dosage</subject><subject>dietary fiber</subject><subject>Dietary Fiber - pharmacology</subject><subject>Dietary Fiber - therapeutic use</subject><subject>Dietary Supplements</subject><subject>Diets</subject><subject>Fibers</subject><subject>food intake</subject><subject>Food science</subject><subject>Foods</subject><subject>gene expression</subject><subject>genes</subject><subject>high fat diet</subject><subject>ICR mice</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>leptin</subject><subject>Leptin - blood</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipids</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>messenger RNA</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mice, Obese</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Salicornia europaea</subject><subject>Salicornia herbacea</subject><subject>Sodium chloride</subject><subject>Sodium Chloride, Dietary - administration & dosage</subject><subject>triacylglycerols</subject><subject>Triglycerides - blood</subject><subject>weight gain</subject><subject>Weight Gain - drug effects</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0stu1DAUBmALgehQWPACYIkNm7S-O1lWI3oZVQUxVCytE8ee8ZAbcULbXR-BZ-RJcDSlCzawsuXznSNbvxF6TckRJYQd76KHI02keIIWlBQ6I4SSp2iRaiyTVLAD9CLGHSGkKJR6jg6YlIxLqhaoW0MdbDe0AfDWDSVYB7gf3A_XjhHfuLDZjngDocXQVkn0MAaL69CHCoO1UzPV6aRrcRJd6aLDF8vPuAnWYe8Swds04df9Tw8jroIbX6JnHuroXj2sh-j69MOX5Xl2-fHsYnlymVlJtcicd94WICWRoHNVVZ7lknDvhXZSVZx6qCrltS-UpqUCUQJlJTAQlRUAnh-i9_u5_dB9n1wcTROidXUNreumaGhOpSpEzsm_qdaEC04J-w_KdFFIkutE3_1Fd900tOnNSfGUTE4FT-rNg5rKxlWmH0IDw535E1ACx3twE2p391inxMzJmzl5MydvVuvTk3mTOrJ9R4iju33sgOGbUZprab5enRmxXp2Tq9UnM_u3e--hM7AZQjTXa0aomj9RXqRL_gZzabi6</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Pichiah, PB Tirupathi</creator><creator>Cha, Youn‐Soo</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>7U7</scope></search><sort><creationdate>201512</creationdate><title>Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high‐fat diet</title><author>Pichiah, PB Tirupathi ; Cha, Youn‐Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5174-efefc9a5505a786ddf28503ff47e56d31fadd6f7f9671b6a4ba12ba2a4dc4aaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>adipose tissue</topic><topic>adipose tissue, leptin</topic><topic>Animals</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Anti-Obesity Agents - therapeutic use</topic><topic>blood serum</topic><topic>body weight changes</topic><topic>Cellulose</topic><topic>Chenopodiaceae - chemistry</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Dietary Fats - administration & dosage</topic><topic>dietary fiber</topic><topic>Dietary Fiber - pharmacology</topic><topic>Dietary Fiber - therapeutic use</topic><topic>Dietary Supplements</topic><topic>Diets</topic><topic>Fibers</topic><topic>food intake</topic><topic>Food science</topic><topic>Foods</topic><topic>gene expression</topic><topic>genes</topic><topic>high fat diet</topic><topic>ICR mice</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>leptin</topic><topic>Leptin - blood</topic><topic>Lipid Metabolism - genetics</topic><topic>Lipids</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>messenger RNA</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mice, Obese</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Salicornia europaea</topic><topic>Salicornia herbacea</topic><topic>Sodium chloride</topic><topic>Sodium Chloride, Dietary - administration & dosage</topic><topic>triacylglycerols</topic><topic>Triglycerides - blood</topic><topic>weight gain</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pichiah, PB Tirupathi</creatorcontrib><creatorcontrib>Cha, Youn‐Soo</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pichiah, PB Tirupathi</au><au>Cha, Youn‐Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high‐fat diet</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2015-12</date><risdate>2015</risdate><volume>95</volume><issue>15</issue><spage>3150</spage><epage>3159</epage><pages>3150-3159</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>BACKGROUND: Foods that are rich in fat and or sodium chloride promote obesity and associated diseases, whereas intake of dietary fiber averts obesity development. Salicornia herbacea (SH) is a rich source of dietary fiber and high in sodium chloride; therefore, we investigated whether replacing common salt with SH in a high‐fat diet could prevent obesity development. RESULTS: Mice were divided into five groups: group ND was fed a normal diet, group HD was fed a high‐fat diet, group HD‐NaCl was fed a high fat diet with sodium chloride 10 g kg⁻¹, group HD‐CL was fed a high‐fat diet with cellulose 30 g kg⁻¹ and group HD‐SH was fed a high‐fat diet with SH powder 50 g kg⁻¹. The amount of sodium chloride and cellulose added in the respective diet was equivalent to their amount in SH. Data from our study showed that, SH supplementation significantly decreased body weight gain, liver weight, hepatic triglyceride, serum leptin and insulin, along with the mRNA level of key lipid anabolic genes such as SREBP‐1c, PPARγ and FAS compared to the HD group. CONCLUSION: The results of this study demonstrated that SH is a potential natural anti‐obesity agent that can be used in place of sodium chloride. © 2014 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>25523516</pmid><doi>10.1002/jsfa.7054</doi><tpages>10</tpages></addata></record> |
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| subjects | adipose tissue adipose tissue, leptin Animals Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use blood serum body weight changes Cellulose Chenopodiaceae - chemistry Diet Diet, High-Fat Dietary Fats - administration & dosage dietary fiber Dietary Fiber - pharmacology Dietary Fiber - therapeutic use Dietary Supplements Diets Fibers food intake Food science Foods gene expression genes high fat diet ICR mice insulin Insulin - blood leptin Leptin - blood Lipid Metabolism - genetics Lipids liver Liver - drug effects Liver - metabolism Male messenger RNA Mice Mice, Inbred ICR Mice, Obese Obesity Obesity - drug therapy Obesity - genetics Obesity - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use RNA, Messenger - metabolism Rodents Salicornia europaea Salicornia herbacea Sodium chloride Sodium Chloride, Dietary - administration & dosage triacylglycerols Triglycerides - blood weight gain Weight Gain - drug effects |
| title | Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high‐fat diet |
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