Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma

Sebaceous carcinoma (SC) is a rare but aggressive malignancy with frequent recurrence and metastases. Surgery is the mainstay of therapy, but effective systemic therapies are lacking because the molecular alterations driving SC remain poorly understood. To identify these, we performed whole‐exome ne...

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Veröffentlicht in:The Journal of pathology 2016-09, Vol.240 (1), p.84-95
Hauptverfasser: Tetzlaff, Michael T, Singh, Rajesh R, Seviour, Elena G, Curry, Jonathan L, Hudgens, Courtney W, Bell, Diana, Wimmer, Daniel A, Ning, Jing, Czerniak, Bogdan A, Zhang, Li, Davies, Michael A, Prieto, Victor G, Broaddus, Russell R, Ram, Prahlad, Luthra, Rajyalakshmi, Esmaeli, Bita
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Sprache:eng
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