Association between urinary lead and bone health in a general population from Taiwan

Lead accumulates in adult bones for many decades; previous studies have shown lead’s detrimental effects on osteoblast and osteoclast activity in association with bone remodeling. Osteoporosis is a disease of the bones resulting in low bone mass that induces fragile bones and hence susceptibility of...

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Veröffentlicht in:Journal of exposure science & environmental epidemiology 2016-09, Vol.26 (5), p.481-487
Hauptverfasser: Tsai, Tsung-Lin, Pan, Wen-Harn, Chung, Yu-Teh, Wu, Trong-Neng, Tseng, Ying-Chih, Liou, Saou-Hsing, Wang, Shu-Li
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container_issue 5
container_start_page 481
container_title Journal of exposure science & environmental epidemiology
container_volume 26
creator Tsai, Tsung-Lin
Pan, Wen-Harn
Chung, Yu-Teh
Wu, Trong-Neng
Tseng, Ying-Chih
Liou, Saou-Hsing
Wang, Shu-Li
description Lead accumulates in adult bones for many decades; previous studies have shown lead’s detrimental effects on osteoblast and osteoclast activity in association with bone remodeling. Osteoporosis is a disease of the bones resulting in low bone mass that induces fragile bones and hence susceptibility of fracture. We estimated the association between urinary lead (U-Pb) levels and bone health in adults participating in the third Nutrition and Health Survey in Taiwan (NAHSIT) from 2005 to 2008. A total of 398 participants were divided into normal (T-score>−1), osteopenic (T-score between −1 and −2.5), or osteoporotic (T-score
doi_str_mv 10.1038/jes.2015.30
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Osteoporosis is a disease of the bones resulting in low bone mass that induces fragile bones and hence susceptibility of fracture. We estimated the association between urinary lead (U-Pb) levels and bone health in adults participating in the third Nutrition and Health Survey in Taiwan (NAHSIT) from 2005 to 2008. A total of 398 participants were divided into normal (T-score&gt;−1), osteopenic (T-score between −1 and −2.5), or osteoporotic (T-score&lt;−2.5) groups according to the results of bone mineral density (BMD) measurements. Heavy metals were measured in urine specimens using inductively coupled plasma-mass spectrometry. In the multivariable logistic regression analysis, age (OR=1.08; 95% CI=1.05–1.10), former smokers (OR=2.95; 95% CI=1.22–7.11) and higher U-Pb levels than upper tertile (OR=2.30; 95% CI=1.19–4.48) were associated with osteopenia/osteoporosis. Furthermore, age (OR=1.06; 95% CI=1.02–1.10) and higher U-Pb levels (OR=2.81; 95% CI=1.13–6.97) were significantly associated with osteopenia and osteoporosis in women. 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subjects 692/699/2743/316/801
692/700/478/174
704/172/169/895
Adult
Adults
Age Factors
Aged
Biomedical materials
Body Mass Index
Bone Density - drug effects
Bone Diseases, Metabolic - chemically induced
Bone Diseases, Metabolic - epidemiology
Bone Diseases, Metabolic - urine
Bone mass
Bone mineral density
Bone remodeling
Bones
Diagnosis
Epidemiology
Female
Health aspects
Health Surveys
Heavy metals
Humans
Inductively coupled plasma mass spectrometry
Lead
Lead - adverse effects
Lead - urine
Lead in the body
Logistic Models
Male
Mass Spectrometry
Mass spectroscopy
Medicine
Medicine & Public Health
Menopause
Middle Aged
Nutrition
original-article
Osteopenia
Osteoporosis
Osteoporosis - urine
Regression analysis
Risk factors
Smoking
Taiwan - epidemiology
title Association between urinary lead and bone health in a general population from Taiwan
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