Eugenol Ameliorates Hepatic Steatosis and Fibrosis by Down-Regulating SREBP1 Gene Expression via AMPK-mTOR-p70S6K Signaling Pathway

Beneficial effect of eugenol on fatty liver was examined in hepatocytes and liver tissue of high fat diet (HFD)-fed C57BL/6J mice. To induce a fatty liver, palmitic acid or isolated hepatocytes from HFD-fed Sprague-Dawley (SD) rats were used in vitro studies, and C57BL/6J mice were fed HFD for 10 we...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 2014/08/01, Vol.37(8), pp.1341-1351
Hauptverfasser:	Jo, Hee Kyung, Kim, Go Woon, Jeong, Kyung Ju, Kim, Do Yeon, Chung, Sung Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - metabolism Actins - genetics AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Cells, Cultured Collagen Type I - genetics Down-Regulation eugenol Eugenol - pharmacology Eugenol - therapeutic use fatty liver Fatty Liver - drug therapy Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Fibrosis Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Humans Liver - pathology Male Mice, Inbred C57BL Plasminogen Activator Inhibitor 1 - genetics Rats, Sprague-Dawley Ribosomal Protein S6 Kinases, 70-kDa - metabolism sterol regulatory element binding protein Sterol Regulatory Element Binding Protein 1 - genetics TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!