Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease
The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of 18F-FDG PET/CT in the diagnostic combination strategy as...
Gespeichert in:
| Veröffentlicht in: | Netherlands journal of medicine 2016-08, Vol.74 (7), p.301-308 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 308 |
|---|---|
| container_issue | 7 |
| container_start_page | 301 |
| container_title | Netherlands journal of medicine |
| container_volume | 74 |
| creator | Hagenaars, J C J P Wever, P C Vlake, A W Renders, N H M van Petersen, A S Hilbink, M de Jager-Leclercq, M G L Moll, F L Koning, O H J Hoekstra, C J |
| description | The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of 18F-FDG PET/CT in the diagnostic combination strategy as described in the Dutch consensus guideline for diagnosing chronic Q fever.
18F-FDG PET/CT was performed in patients with an abdominal aortic aneurysm or aorto-iliac reconstruction and chronic Q fever, diagnosed by serology and positive PCR for Coxiella burnetii DNA in blood and/or tissue (PCR-positive study group). Patients with an abdominal aortic aneurysm or aorto-iliac reconstruction without clinical and serological findings indicating Q fever infection served as a control group. Patients with a serological profile of chronic Q fever and a negative PCR in blood were included in additional analyses (PCR-negative study group).
Thirteen patients were evaluated in the PCR-positive study group and 22 patients in the control group. 18F-FDG PET/CT indicated vascular infection in 6/13 patients in the PCR-positive study group and 2/22 patients in the control group. 18F-FDG PET/CT demonstrated a sensitivity of 46% (95% CI: 23-71%), specificity of 91% (95% CI: 71-99%), positive predictive value of 75% (95% CI:41-93%) and negative predictive value of 74% (95% CI: 55-87%). In the PCR-negative study group, 18F-FDG PET/CT was positive in 10/20 patients (50%).
The combination of 18F-FDG PET/CT, as an imaging tool for identifying a focus of infection, and Q fever serology is a valid diagnostic strategy for diagnosing chronic Q fever in patients with central vascular disease. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1815682075</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1815682075</sourcerecordid><originalsourceid>FETCH-LOGICAL-p565-c7f353235e873926719c3b225babfc835223cb411429aff48ea2f62f8682cfec3</originalsourceid><addsrcrecordid>eNo1kF9LwzAUxYMgbk6_guTRl2KTNE36KHXdhIEKxddym91skf4zaSd-eyvOp3Pg_M7lci7IkmnFoyxO2YJch_ARx3GqMnlFFlxJxbJELkn1Ds2EtLeU6SIqnjb0dV0-5CV1Hd07OHR9cN2BmqPvO2foG7V4Qv-bDjA67MZAv9x4pGa2Hhp6gmCmBvxcDggBb8ilhSbg7VlXpCzWZb6Ndi-b5_xxFw0ylZFRVkjBhUStRMbT-Tkjas5lDbU1WkjOhakTxhKegbWJRuA25VanmhuLRqzI_d_ZwfefE4axal0w2DTQYT-FimkmZzZWckbvzuhUt7ivBu9a8N_V_ybiBwHOWts</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1815682075</pqid></control><display><type>article</type><title>Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hagenaars, J C J P ; Wever, P C ; Vlake, A W ; Renders, N H M ; van Petersen, A S ; Hilbink, M ; de Jager-Leclercq, M G L ; Moll, F L ; Koning, O H J ; Hoekstra, C J</creator><creatorcontrib>Hagenaars, J C J P ; Wever, P C ; Vlake, A W ; Renders, N H M ; van Petersen, A S ; Hilbink, M ; de Jager-Leclercq, M G L ; Moll, F L ; Koning, O H J ; Hoekstra, C J</creatorcontrib><description>The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of 18F-FDG PET/CT in the diagnostic combination strategy as described in the Dutch consensus guideline for diagnosing chronic Q fever.
18F-FDG PET/CT was performed in patients with an abdominal aortic aneurysm or aorto-iliac reconstruction and chronic Q fever, diagnosed by serology and positive PCR for Coxiella burnetii DNA in blood and/or tissue (PCR-positive study group). Patients with an abdominal aortic aneurysm or aorto-iliac reconstruction without clinical and serological findings indicating Q fever infection served as a control group. Patients with a serological profile of chronic Q fever and a negative PCR in blood were included in additional analyses (PCR-negative study group).
Thirteen patients were evaluated in the PCR-positive study group and 22 patients in the control group. 18F-FDG PET/CT indicated vascular infection in 6/13 patients in the PCR-positive study group and 2/22 patients in the control group. 18F-FDG PET/CT demonstrated a sensitivity of 46% (95% CI: 23-71%), specificity of 91% (95% CI: 71-99%), positive predictive value of 75% (95% CI:41-93%) and negative predictive value of 74% (95% CI: 55-87%). In the PCR-negative study group, 18F-FDG PET/CT was positive in 10/20 patients (50%).
The combination of 18F-FDG PET/CT, as an imaging tool for identifying a focus of infection, and Q fever serology is a valid diagnostic strategy for diagnosing chronic Q fever in patients with central vascular disease.</description><identifier>EISSN: 1872-9061</identifier><identifier>PMID: 27571945</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Aortic Aneurysm, Abdominal - diagnostic imaging ; Aortic Aneurysm, Abdominal - microbiology ; Aortic Diseases - diagnosis ; Aortic Diseases - diagnostic imaging ; Aortic Diseases - microbiology ; Blood Vessel Prosthesis - microbiology ; Coxiella burnetii - genetics ; DNA, Bacterial - analysis ; Fluorodeoxyglucose F18 ; Humans ; Iliac Artery - diagnostic imaging ; Iliac Artery - microbiology ; Iliac Artery - surgery ; Polymerase Chain Reaction ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prosthesis-Related Infections - diagnosis ; Prosthesis-Related Infections - diagnostic imaging ; Prosthesis-Related Infections - microbiology ; Q Fever - diagnosis ; Q Fever - diagnostic imaging ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Vascular Diseases - diagnosis ; Vascular Diseases - diagnostic imaging ; Vascular Diseases - microbiology</subject><ispartof>Netherlands journal of medicine, 2016-08, Vol.74 (7), p.301-308</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27571945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagenaars, J C J P</creatorcontrib><creatorcontrib>Wever, P C</creatorcontrib><creatorcontrib>Vlake, A W</creatorcontrib><creatorcontrib>Renders, N H M</creatorcontrib><creatorcontrib>van Petersen, A S</creatorcontrib><creatorcontrib>Hilbink, M</creatorcontrib><creatorcontrib>de Jager-Leclercq, M G L</creatorcontrib><creatorcontrib>Moll, F L</creatorcontrib><creatorcontrib>Koning, O H J</creatorcontrib><creatorcontrib>Hoekstra, C J</creatorcontrib><title>Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease</title><title>Netherlands journal of medicine</title><addtitle>Neth J Med</addtitle><description>The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of 18F-FDG PET/CT in the diagnostic combination strategy as described in the Dutch consensus guideline for diagnosing chronic Q fever.
18F-FDG PET/CT was performed in patients with an abdominal aortic aneurysm or aorto-iliac reconstruction and chronic Q fever, diagnosed by serology and positive PCR for Coxiella burnetii DNA in blood and/or tissue (PCR-positive study group). Patients with an abdominal aortic aneurysm or aorto-iliac reconstruction without clinical and serological findings indicating Q fever infection served as a control group. Patients with a serological profile of chronic Q fever and a negative PCR in blood were included in additional analyses (PCR-negative study group).
Thirteen patients were evaluated in the PCR-positive study group and 22 patients in the control group. 18F-FDG PET/CT indicated vascular infection in 6/13 patients in the PCR-positive study group and 2/22 patients in the control group. 18F-FDG PET/CT demonstrated a sensitivity of 46% (95% CI: 23-71%), specificity of 91% (95% CI: 71-99%), positive predictive value of 75% (95% CI:41-93%) and negative predictive value of 74% (95% CI: 55-87%). In the PCR-negative study group, 18F-FDG PET/CT was positive in 10/20 patients (50%).
The combination of 18F-FDG PET/CT, as an imaging tool for identifying a focus of infection, and Q fever serology is a valid diagnostic strategy for diagnosing chronic Q fever in patients with central vascular disease.</description><subject>Aortic Aneurysm, Abdominal - diagnostic imaging</subject><subject>Aortic Aneurysm, Abdominal - microbiology</subject><subject>Aortic Diseases - diagnosis</subject><subject>Aortic Diseases - diagnostic imaging</subject><subject>Aortic Diseases - microbiology</subject><subject>Blood Vessel Prosthesis - microbiology</subject><subject>Coxiella burnetii - genetics</subject><subject>DNA, Bacterial - analysis</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Iliac Artery - diagnostic imaging</subject><subject>Iliac Artery - microbiology</subject><subject>Iliac Artery - surgery</subject><subject>Polymerase Chain Reaction</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Prospective Studies</subject><subject>Prosthesis-Related Infections - diagnosis</subject><subject>Prosthesis-Related Infections - diagnostic imaging</subject><subject>Prosthesis-Related Infections - microbiology</subject><subject>Q Fever - diagnosis</subject><subject>Q Fever - diagnostic imaging</subject><subject>Radiopharmaceuticals</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Vascular Diseases - diagnosis</subject><subject>Vascular Diseases - diagnostic imaging</subject><subject>Vascular Diseases - microbiology</subject><issn>1872-9061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF9LwzAUxYMgbk6_guTRl2KTNE36KHXdhIEKxddym91skf4zaSd-eyvOp3Pg_M7lci7IkmnFoyxO2YJch_ARx3GqMnlFFlxJxbJELkn1Ds2EtLeU6SIqnjb0dV0-5CV1Hd07OHR9cN2BmqPvO2foG7V4Qv-bDjA67MZAv9x4pGa2Hhp6gmCmBvxcDggBb8ilhSbg7VlXpCzWZb6Ndi-b5_xxFw0ylZFRVkjBhUStRMbT-Tkjas5lDbU1WkjOhakTxhKegbWJRuA25VanmhuLRqzI_d_ZwfefE4axal0w2DTQYT-FimkmZzZWckbvzuhUt7ivBu9a8N_V_ybiBwHOWts</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Hagenaars, J C J P</creator><creator>Wever, P C</creator><creator>Vlake, A W</creator><creator>Renders, N H M</creator><creator>van Petersen, A S</creator><creator>Hilbink, M</creator><creator>de Jager-Leclercq, M G L</creator><creator>Moll, F L</creator><creator>Koning, O H J</creator><creator>Hoekstra, C J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease</title><author>Hagenaars, J C J P ; Wever, P C ; Vlake, A W ; Renders, N H M ; van Petersen, A S ; Hilbink, M ; de Jager-Leclercq, M G L ; Moll, F L ; Koning, O H J ; Hoekstra, C J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p565-c7f353235e873926719c3b225babfc835223cb411429aff48ea2f62f8682cfec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aortic Aneurysm, Abdominal - diagnostic imaging</topic><topic>Aortic Aneurysm, Abdominal - microbiology</topic><topic>Aortic Diseases - diagnosis</topic><topic>Aortic Diseases - diagnostic imaging</topic><topic>Aortic Diseases - microbiology</topic><topic>Blood Vessel Prosthesis - microbiology</topic><topic>Coxiella burnetii - genetics</topic><topic>DNA, Bacterial - analysis</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Iliac Artery - diagnostic imaging</topic><topic>Iliac Artery - microbiology</topic><topic>Iliac Artery - surgery</topic><topic>Polymerase Chain Reaction</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Prospective Studies</topic><topic>Prosthesis-Related Infections - diagnosis</topic><topic>Prosthesis-Related Infections - diagnostic imaging</topic><topic>Prosthesis-Related Infections - microbiology</topic><topic>Q Fever - diagnosis</topic><topic>Q Fever - diagnostic imaging</topic><topic>Radiopharmaceuticals</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Vascular Diseases - diagnosis</topic><topic>Vascular Diseases - diagnostic imaging</topic><topic>Vascular Diseases - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagenaars, J C J P</creatorcontrib><creatorcontrib>Wever, P C</creatorcontrib><creatorcontrib>Vlake, A W</creatorcontrib><creatorcontrib>Renders, N H M</creatorcontrib><creatorcontrib>van Petersen, A S</creatorcontrib><creatorcontrib>Hilbink, M</creatorcontrib><creatorcontrib>de Jager-Leclercq, M G L</creatorcontrib><creatorcontrib>Moll, F L</creatorcontrib><creatorcontrib>Koning, O H J</creatorcontrib><creatorcontrib>Hoekstra, C J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Netherlands journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagenaars, J C J P</au><au>Wever, P C</au><au>Vlake, A W</au><au>Renders, N H M</au><au>van Petersen, A S</au><au>Hilbink, M</au><au>de Jager-Leclercq, M G L</au><au>Moll, F L</au><au>Koning, O H J</au><au>Hoekstra, C J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease</atitle><jtitle>Netherlands journal of medicine</jtitle><addtitle>Neth J Med</addtitle><date>2016-08</date><risdate>2016</risdate><volume>74</volume><issue>7</issue><spage>301</spage><epage>308</epage><pages>301-308</pages><eissn>1872-9061</eissn><abstract>The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of 18F-FDG PET/CT in the diagnostic combination strategy as described in the Dutch consensus guideline for diagnosing chronic Q fever.
18F-FDG PET/CT was performed in patients with an abdominal aortic aneurysm or aorto-iliac reconstruction and chronic Q fever, diagnosed by serology and positive PCR for Coxiella burnetii DNA in blood and/or tissue (PCR-positive study group). Patients with an abdominal aortic aneurysm or aorto-iliac reconstruction without clinical and serological findings indicating Q fever infection served as a control group. Patients with a serological profile of chronic Q fever and a negative PCR in blood were included in additional analyses (PCR-negative study group).
Thirteen patients were evaluated in the PCR-positive study group and 22 patients in the control group. 18F-FDG PET/CT indicated vascular infection in 6/13 patients in the PCR-positive study group and 2/22 patients in the control group. 18F-FDG PET/CT demonstrated a sensitivity of 46% (95% CI: 23-71%), specificity of 91% (95% CI: 71-99%), positive predictive value of 75% (95% CI:41-93%) and negative predictive value of 74% (95% CI: 55-87%). In the PCR-negative study group, 18F-FDG PET/CT was positive in 10/20 patients (50%).
The combination of 18F-FDG PET/CT, as an imaging tool for identifying a focus of infection, and Q fever serology is a valid diagnostic strategy for diagnosing chronic Q fever in patients with central vascular disease.</abstract><cop>Netherlands</cop><pmid>27571945</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1872-9061 |
| ispartof | Netherlands journal of medicine, 2016-08, Vol.74 (7), p.301-308 |
| issn | 1872-9061 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1815682075 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aortic Aneurysm, Abdominal - diagnostic imaging Aortic Aneurysm, Abdominal - microbiology Aortic Diseases - diagnosis Aortic Diseases - diagnostic imaging Aortic Diseases - microbiology Blood Vessel Prosthesis - microbiology Coxiella burnetii - genetics DNA, Bacterial - analysis Fluorodeoxyglucose F18 Humans Iliac Artery - diagnostic imaging Iliac Artery - microbiology Iliac Artery - surgery Polymerase Chain Reaction Positron Emission Tomography Computed Tomography Prospective Studies Prosthesis-Related Infections - diagnosis Prosthesis-Related Infections - diagnostic imaging Prosthesis-Related Infections - microbiology Q Fever - diagnosis Q Fever - diagnostic imaging Radiopharmaceuticals Retrospective Studies Sensitivity and Specificity Vascular Diseases - diagnosis Vascular Diseases - diagnostic imaging Vascular Diseases - microbiology |
| title | Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T00%3A47%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Value%20of%2018F-FDG%20PET/CT%20in%20diagnosing%20chronic%20Q%20fever%20in%20patients%20with%20central%20vascular%20disease&rft.jtitle=Netherlands%20journal%20of%20medicine&rft.au=Hagenaars,%20J%20C%20J%20P&rft.date=2016-08&rft.volume=74&rft.issue=7&rft.spage=301&rft.epage=308&rft.pages=301-308&rft.eissn=1872-9061&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1815682075%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1815682075&rft_id=info:pmid/27571945&rfr_iscdi=true |