Synthesis and characterization of PEGylated bolaamphiphiles with enhanced retention in liposomes

[Display omitted] Long-circulating liposomes are typically prepared with poly(ethylene glycol)- (PEG-) modified lipids, where the lipid portion is inserted in the lipid bilayers as an anchor and the hydrophilic PEG coats the surface to prevent liposome aggregation and rapid clearance in vivo. Howeve...

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Veröffentlicht in:	Journal of colloid and interface science 2016-11, Vol.482, p.19-26
Hauptverfasser:	Zhang, Yingyue, Mintzer, Evan, Uhrich, Kathryn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine - chemistry Air - analysis Bolaamphiphile Cholesterol - chemistry Drug delivery Furans - chemical synthesis Furans - chemistry Humans Hydrophobic and Hydrophilic Interactions Kinetics Lipid Bilayers - chemistry Lipid Bilayers - pharmacology Liposomes Liposomes - chemistry Liposomes - pharmacology Long-circulation Macrophages - cytology Macrophages - drug effects Particle Size PEGylated lipids Phagocytosis - drug effects Polyethylene Glycols - chemistry Pyridones - chemical synthesis Pyridones - chemistry Steric stabilization Surface Properties Water - chemistry
Online-Zugang:	Volltext
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