Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial
Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology. The aim of our study was to evaluate the effects of peri-procedural ad...
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| Veröffentlicht in: | Revista de gastroenterología de México 2016-07, Vol.81 (3), p.141-148 |
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| creator | Hernández-Velázquez, B Camara-Lemarroy, C R González-González, J A García-Compean, D Monreal-Robles, R Cordero-Pérez, P Muñoz-Espinosa, L E |
| description | Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology.
The aim of our study was to evaluate the effects of peri-procedural administration of melatonin on the inflammatory response and lipid peroxidation associated with ERCP.
In this proof-of-concept clinical trial, 37 patients with a high probability of choledocholithiasis were randomized to receive peri-procedure (ERCP) melatonin or placebo. We measured the serum concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), lipid peroxidation, amylase, and liver function tests 24h before and after the procedure.
We found no pre-procedure or post-procedure differences between the melatonin group or the placebo group (P>.05) in the serum concentrations of TNF-alpha (melatonin: 153.8 vs. 149.4ng/m; placebo: 103.5 vs. 107.3ng/ml), IL-6 (melatonin: 131.8 vs. 133.3ng/ml; placebo: 177.8 vs. 197.8ng/ml), or VEGF (melatonin: 157.3 vs. 157.8pg/ml; placebo: 97.3 vs. 97.8pg/ml), or in relation to lipid peroxidation (melatonin: 39.2 vs. 72.3μg/ml; placebo: 66.4 vs. 90.5μg/ml). After ERCP, a significant decrease in the AST, ALT, and total bilirubin levels was found only in the melatonin group (P |
| doi_str_mv | 10.1016/j.rgmx.2016.03.003 |
| format | Article |
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The aim of our study was to evaluate the effects of peri-procedural administration of melatonin on the inflammatory response and lipid peroxidation associated with ERCP.
In this proof-of-concept clinical trial, 37 patients with a high probability of choledocholithiasis were randomized to receive peri-procedure (ERCP) melatonin or placebo. We measured the serum concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), lipid peroxidation, amylase, and liver function tests 24h before and after the procedure.
We found no pre-procedure or post-procedure differences between the melatonin group or the placebo group (P>.05) in the serum concentrations of TNF-alpha (melatonin: 153.8 vs. 149.4ng/m; placebo: 103.5 vs. 107.3ng/ml), IL-6 (melatonin: 131.8 vs. 133.3ng/ml; placebo: 177.8 vs. 197.8ng/ml), or VEGF (melatonin: 157.3 vs. 157.8pg/ml; placebo: 97.3 vs. 97.8pg/ml), or in relation to lipid peroxidation (melatonin: 39.2 vs. 72.3μg/ml; placebo: 66.4 vs. 90.5μg/ml). After ERCP, a significant decrease in the AST, ALT, and total bilirubin levels was found only in the melatonin group (P<.05). The administration of melatonin was safe and tolerable.
Melatonin is safe and tolerable in patients undergoing ERCP, but it does not appear to affect inflammatory cytokine concentrations or lipid peroxidation.</description><identifier>ISSN: 0375-0906</identifier><identifier>DOI: 10.1016/j.rgmx.2016.03.003</identifier><identifier>PMID: 27320538</identifier><language>eng ; spa</language><publisher>Mexico</publisher><subject>Adult ; Aged ; Antioxidants - adverse effects ; Antioxidants - therapeutic use ; Cholangiopancreatography, Endoscopic Retrograde - adverse effects ; Choledocholithiasis - complications ; Choledocholithiasis - diagnosis ; Cytokines - blood ; Double-Blind Method ; Female ; Humans ; Inflammation - etiology ; Inflammation - prevention & control ; Lipid Peroxidation - drug effects ; Male ; Melatonin - adverse effects ; Melatonin - therapeutic use ; Middle Aged</subject><ispartof>Revista de gastroenterología de México, 2016-07, Vol.81 (3), p.141-148</ispartof><rights>Copyright © 2016 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27320538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernández-Velázquez, B</creatorcontrib><creatorcontrib>Camara-Lemarroy, C R</creatorcontrib><creatorcontrib>González-González, J A</creatorcontrib><creatorcontrib>García-Compean, D</creatorcontrib><creatorcontrib>Monreal-Robles, R</creatorcontrib><creatorcontrib>Cordero-Pérez, P</creatorcontrib><creatorcontrib>Muñoz-Espinosa, L E</creatorcontrib><title>Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial</title><title>Revista de gastroenterología de México</title><addtitle>Rev Gastroenterol Mex</addtitle><description>Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology.
The aim of our study was to evaluate the effects of peri-procedural administration of melatonin on the inflammatory response and lipid peroxidation associated with ERCP.
In this proof-of-concept clinical trial, 37 patients with a high probability of choledocholithiasis were randomized to receive peri-procedure (ERCP) melatonin or placebo. We measured the serum concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), lipid peroxidation, amylase, and liver function tests 24h before and after the procedure.
We found no pre-procedure or post-procedure differences between the melatonin group or the placebo group (P>.05) in the serum concentrations of TNF-alpha (melatonin: 153.8 vs. 149.4ng/m; placebo: 103.5 vs. 107.3ng/ml), IL-6 (melatonin: 131.8 vs. 133.3ng/ml; placebo: 177.8 vs. 197.8ng/ml), or VEGF (melatonin: 157.3 vs. 157.8pg/ml; placebo: 97.3 vs. 97.8pg/ml), or in relation to lipid peroxidation (melatonin: 39.2 vs. 72.3μg/ml; placebo: 66.4 vs. 90.5μg/ml). After ERCP, a significant decrease in the AST, ALT, and total bilirubin levels was found only in the melatonin group (P<.05). The administration of melatonin was safe and tolerable.
Melatonin is safe and tolerable in patients undergoing ERCP, but it does not appear to affect inflammatory cytokine concentrations or lipid peroxidation.</description><subject>Adult</subject><subject>Aged</subject><subject>Antioxidants - adverse effects</subject><subject>Antioxidants - therapeutic use</subject><subject>Cholangiopancreatography, Endoscopic Retrograde - adverse effects</subject><subject>Choledocholithiasis - complications</subject><subject>Choledocholithiasis - diagnosis</subject><subject>Cytokines - blood</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - etiology</subject><subject>Inflammation - prevention & control</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Melatonin - adverse effects</subject><subject>Melatonin - therapeutic use</subject><subject>Middle Aged</subject><issn>0375-0906</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM9O3DAQxn2gArrwAhyQjz006TjeTbK9IQQFaaVe4Bw54_GukWMH21G7PBMPiaXS0_z5vvmNZhi7ElALEO2Plzrup791U_IaZA0gT9g5yG5TwRbaM_Y1pRcAaHtoTtlZ08kGNrI_Z-93xhDmxIPhEzmVg7eeB8_zgbjCJRO33jg1TUWKRx4pzcGnoqUU0KpMmv-x-cDJ65AwzBaLJ8ewj0oTx0Nwyu9tmJXHSIVR-vPh-JPf8KjKyGTfSH_nOiyjo2p01pdqdgppDBUGX0jOlR05WuUu2BejXKLLz7hiz_d3T7cP1e73r8fbm101i7XI1XYz9qJptiP2nTaj6BrTo1ACzEgaEbZSSoNoZL_GTpISbWs6Q6ZXawVCa7li3_5x5xheF0p5mGxCcuUUCksaRC82shPtGor1-tO6jBPpYY52UvE4_P-w_ADq4YL5</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Hernández-Velázquez, B</creator><creator>Camara-Lemarroy, C R</creator><creator>González-González, J A</creator><creator>García-Compean, D</creator><creator>Monreal-Robles, R</creator><creator>Cordero-Pérez, P</creator><creator>Muñoz-Espinosa, L E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial</title><author>Hernández-Velázquez, B ; Camara-Lemarroy, C R ; González-González, J A ; García-Compean, D ; Monreal-Robles, R ; Cordero-Pérez, P ; Muñoz-Espinosa, L E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-95b81229bc87dfb172f8c1a10fbedcc09333fccf384c73ea166f7fef8a4a01dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antioxidants - adverse effects</topic><topic>Antioxidants - therapeutic use</topic><topic>Cholangiopancreatography, Endoscopic Retrograde - adverse effects</topic><topic>Choledocholithiasis - complications</topic><topic>Choledocholithiasis - diagnosis</topic><topic>Cytokines - blood</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - etiology</topic><topic>Inflammation - prevention & control</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Melatonin - adverse effects</topic><topic>Melatonin - therapeutic use</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernández-Velázquez, B</creatorcontrib><creatorcontrib>Camara-Lemarroy, C R</creatorcontrib><creatorcontrib>González-González, J A</creatorcontrib><creatorcontrib>García-Compean, D</creatorcontrib><creatorcontrib>Monreal-Robles, R</creatorcontrib><creatorcontrib>Cordero-Pérez, P</creatorcontrib><creatorcontrib>Muñoz-Espinosa, L E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista de gastroenterología de México</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández-Velázquez, B</au><au>Camara-Lemarroy, C R</au><au>González-González, J A</au><au>García-Compean, D</au><au>Monreal-Robles, R</au><au>Cordero-Pérez, P</au><au>Muñoz-Espinosa, L E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial</atitle><jtitle>Revista de gastroenterología de México</jtitle><addtitle>Rev Gastroenterol Mex</addtitle><date>2016-07</date><risdate>2016</risdate><volume>81</volume><issue>3</issue><spage>141</spage><epage>148</epage><pages>141-148</pages><issn>0375-0906</issn><abstract>Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology.
The aim of our study was to evaluate the effects of peri-procedural administration of melatonin on the inflammatory response and lipid peroxidation associated with ERCP.
In this proof-of-concept clinical trial, 37 patients with a high probability of choledocholithiasis were randomized to receive peri-procedure (ERCP) melatonin or placebo. We measured the serum concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), lipid peroxidation, amylase, and liver function tests 24h before and after the procedure.
We found no pre-procedure or post-procedure differences between the melatonin group or the placebo group (P>.05) in the serum concentrations of TNF-alpha (melatonin: 153.8 vs. 149.4ng/m; placebo: 103.5 vs. 107.3ng/ml), IL-6 (melatonin: 131.8 vs. 133.3ng/ml; placebo: 177.8 vs. 197.8ng/ml), or VEGF (melatonin: 157.3 vs. 157.8pg/ml; placebo: 97.3 vs. 97.8pg/ml), or in relation to lipid peroxidation (melatonin: 39.2 vs. 72.3μg/ml; placebo: 66.4 vs. 90.5μg/ml). After ERCP, a significant decrease in the AST, ALT, and total bilirubin levels was found only in the melatonin group (P<.05). The administration of melatonin was safe and tolerable.
Melatonin is safe and tolerable in patients undergoing ERCP, but it does not appear to affect inflammatory cytokine concentrations or lipid peroxidation.</abstract><cop>Mexico</cop><pmid>27320538</pmid><doi>10.1016/j.rgmx.2016.03.003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antioxidants - adverse effects Antioxidants - therapeutic use Cholangiopancreatography, Endoscopic Retrograde - adverse effects Choledocholithiasis - complications Choledocholithiasis - diagnosis Cytokines - blood Double-Blind Method Female Humans Inflammation - etiology Inflammation - prevention & control Lipid Peroxidation - drug effects Male Melatonin - adverse effects Melatonin - therapeutic use Middle Aged |
| title | Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial |
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