Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus
The risk of coronary heart disease (CHD) is dramatically increased in diabetic patients due to their atherogenic lipid profile. The severity of CHD in diabetic patients has been found to be directly associated with glycated haemoglobin (HbA1c). According to the Malaysian Clinical Practice Guidelines...
Gespeichert in:
| Veröffentlicht in: | Malaysian journal of pathology 2016-08, Vol.38 (2), p.123-130 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 130 |
|---|---|
| container_issue | 2 |
| container_start_page | 123 |
| container_title | Malaysian journal of pathology |
| container_volume | 38 |
| creator | Thambiah, S C Samsudin, I N George, E Zahari Sham, S Y Lee, H M Muhamad, M A Hussei, Z Mohd Noor, N Mohamad, M |
| description | The risk of coronary heart disease (CHD) is dramatically increased in diabetic patients due to their atherogenic lipid profile. The severity of CHD in diabetic patients has been found to be directly associated with glycated haemoglobin (HbA1c). According to the Malaysian Clinical Practice Guidelines on diabetes mellitus (DM), HbA1c level less than 6.5% reduces the risk of microvascular and macrovascular complications. Hence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients in Hospital Putrajaya, a tertiary endocrine centre in Malaysia. This was a cross sectional, retrospective study of 214 T2DM patients with dyslipidaemia who had visited the endocrine clinic between January 2009 and December 2012. Significant correlations were found between fasting blood glucose (FBG) and HbA1c with total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL), non-high density lipoprotein cholesterol (non-HDL), LDL/HDL ratio and TC/HDL ratio; greater correlation being with HbA1c than FBG. In patients with HbA1c ≥ 6.5%, TC, TG, non-HDL and TC/HDL ratio were significantly higher than in patients with HbA1c < 6.5%. Non-HDL, LDL/HDL ratio, TC/HDL ratio and HbA1c were significantly lower in patients on statin treatment than nontreated patients (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1815371058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1815371058</sourcerecordid><originalsourceid>FETCH-LOGICAL-p239t-2c0e0e4796b5c40f43c854288f907a63e10ce2418597badd8690531a1e490bc43</originalsourceid><addsrcrecordid>eNpd0E1LxDAQBuAcFHdd_QsS8OKlkO8mR1n8ggVB1nNJ01k3S5vWJmXpvzeL68XTMPDMy_BeoCWhTBVacblA1zEeCFHCGH2FFqyUSitllsh-QGuT70Pc-wHXkI4AATdzbP3gGwudt9iGBn-1szttDsdk0xSxD3jIhxBSxEef9ng7D4AZbrzNKRBxB23rs7xBlzvbRrg9zxX6fH7arl-LzfvL2_pxUwyMm1QwR4CAKI2qpRNkJ7jTUjCtd4aUVnGgxAETVEtT1rZptDJEcmopCENqJ_gKPfzmDmP_PUFMVeejy0_YAP0UK6qp5CUlUmd6_48e-mkM-buTyt1wwcus7s5qqjtoqmH0nR3n6q88_gPrMGnn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1817563437</pqid></control><display><type>article</type><title>Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Thambiah, S C ; Samsudin, I N ; George, E ; Zahari Sham, S Y ; Lee, H M ; Muhamad, M A ; Hussei, Z ; Mohd Noor, N ; Mohamad, M</creator><creatorcontrib>Thambiah, S C ; Samsudin, I N ; George, E ; Zahari Sham, S Y ; Lee, H M ; Muhamad, M A ; Hussei, Z ; Mohd Noor, N ; Mohamad, M</creatorcontrib><description>The risk of coronary heart disease (CHD) is dramatically increased in diabetic patients due to their atherogenic lipid profile. The severity of CHD in diabetic patients has been found to be directly associated with glycated haemoglobin (HbA1c). According to the Malaysian Clinical Practice Guidelines on diabetes mellitus (DM), HbA1c level less than 6.5% reduces the risk of microvascular and macrovascular complications. Hence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients in Hospital Putrajaya, a tertiary endocrine centre in Malaysia. This was a cross sectional, retrospective study of 214 T2DM patients with dyslipidaemia who had visited the endocrine clinic between January 2009 and December 2012. Significant correlations were found between fasting blood glucose (FBG) and HbA1c with total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL), non-high density lipoprotein cholesterol (non-HDL), LDL/HDL ratio and TC/HDL ratio; greater correlation being with HbA1c than FBG. In patients with HbA1c ≥ 6.5%, TC, TG, non-HDL and TC/HDL ratio were significantly higher than in patients with HbA1c < 6.5%. Non-HDL, LDL/HDL ratio, TC/HDL ratio and HbA1c were significantly lower in patients on statin treatment than nontreated patients (p<0.05). This significant association between glycaemic status and dyslipidaemia emphasises the additional possible use of HbA1c as a biomarker for dyslipidaemia as well as a potential indirect predictor of cardiovascular disease (CVD) risk in T2DM patients.</description><identifier>ISSN: 0126-8635</identifier><identifier>PMID: 27568669</identifier><language>eng</language><publisher>Malaysia: College of Pathologists, Academy of Medicine of Malaysia</publisher><subject>Aged ; Biomarkers - blood ; Blood Glucose - analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Dyslipidemias - blood ; Female ; Glycated Hemoglobin A - analysis ; Glycemic Index ; Humans ; Male ; Middle Aged ; Retrospective Studies</subject><ispartof>Malaysian journal of pathology, 2016-08, Vol.38 (2), p.123-130</ispartof><rights>Copyright College of Pathologists, Academy of Medicine of Malaysia Aug 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27568669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thambiah, S C</creatorcontrib><creatorcontrib>Samsudin, I N</creatorcontrib><creatorcontrib>George, E</creatorcontrib><creatorcontrib>Zahari Sham, S Y</creatorcontrib><creatorcontrib>Lee, H M</creatorcontrib><creatorcontrib>Muhamad, M A</creatorcontrib><creatorcontrib>Hussei, Z</creatorcontrib><creatorcontrib>Mohd Noor, N</creatorcontrib><creatorcontrib>Mohamad, M</creatorcontrib><title>Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus</title><title>Malaysian journal of pathology</title><addtitle>Malays J Pathol</addtitle><description>The risk of coronary heart disease (CHD) is dramatically increased in diabetic patients due to their atherogenic lipid profile. The severity of CHD in diabetic patients has been found to be directly associated with glycated haemoglobin (HbA1c). According to the Malaysian Clinical Practice Guidelines on diabetes mellitus (DM), HbA1c level less than 6.5% reduces the risk of microvascular and macrovascular complications. Hence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients in Hospital Putrajaya, a tertiary endocrine centre in Malaysia. This was a cross sectional, retrospective study of 214 T2DM patients with dyslipidaemia who had visited the endocrine clinic between January 2009 and December 2012. Significant correlations were found between fasting blood glucose (FBG) and HbA1c with total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL), non-high density lipoprotein cholesterol (non-HDL), LDL/HDL ratio and TC/HDL ratio; greater correlation being with HbA1c than FBG. In patients with HbA1c ≥ 6.5%, TC, TG, non-HDL and TC/HDL ratio were significantly higher than in patients with HbA1c < 6.5%. Non-HDL, LDL/HDL ratio, TC/HDL ratio and HbA1c were significantly lower in patients on statin treatment than nontreated patients (p<0.05). This significant association between glycaemic status and dyslipidaemia emphasises the additional possible use of HbA1c as a biomarker for dyslipidaemia as well as a potential indirect predictor of cardiovascular disease (CVD) risk in T2DM patients.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Dyslipidemias - blood</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycemic Index</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><issn>0126-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0E1LxDAQBuAcFHdd_QsS8OKlkO8mR1n8ggVB1nNJ01k3S5vWJmXpvzeL68XTMPDMy_BeoCWhTBVacblA1zEeCFHCGH2FFqyUSitllsh-QGuT70Pc-wHXkI4AATdzbP3gGwudt9iGBn-1szttDsdk0xSxD3jIhxBSxEef9ng7D4AZbrzNKRBxB23rs7xBlzvbRrg9zxX6fH7arl-LzfvL2_pxUwyMm1QwR4CAKI2qpRNkJ7jTUjCtd4aUVnGgxAETVEtT1rZptDJEcmopCENqJ_gKPfzmDmP_PUFMVeejy0_YAP0UK6qp5CUlUmd6_48e-mkM-buTyt1wwcus7s5qqjtoqmH0nR3n6q88_gPrMGnn</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Thambiah, S C</creator><creator>Samsudin, I N</creator><creator>George, E</creator><creator>Zahari Sham, S Y</creator><creator>Lee, H M</creator><creator>Muhamad, M A</creator><creator>Hussei, Z</creator><creator>Mohd Noor, N</creator><creator>Mohamad, M</creator><general>College of Pathologists, Academy of Medicine of Malaysia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus</title><author>Thambiah, S C ; Samsudin, I N ; George, E ; Zahari Sham, S Y ; Lee, H M ; Muhamad, M A ; Hussei, Z ; Mohd Noor, N ; Mohamad, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-2c0e0e4796b5c40f43c854288f907a63e10ce2418597badd8690531a1e490bc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Dyslipidemias - blood</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycemic Index</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thambiah, S C</creatorcontrib><creatorcontrib>Samsudin, I N</creatorcontrib><creatorcontrib>George, E</creatorcontrib><creatorcontrib>Zahari Sham, S Y</creatorcontrib><creatorcontrib>Lee, H M</creatorcontrib><creatorcontrib>Muhamad, M A</creatorcontrib><creatorcontrib>Hussei, Z</creatorcontrib><creatorcontrib>Mohd Noor, N</creatorcontrib><creatorcontrib>Mohamad, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Malaysian journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thambiah, S C</au><au>Samsudin, I N</au><au>George, E</au><au>Zahari Sham, S Y</au><au>Lee, H M</au><au>Muhamad, M A</au><au>Hussei, Z</au><au>Mohd Noor, N</au><au>Mohamad, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus</atitle><jtitle>Malaysian journal of pathology</jtitle><addtitle>Malays J Pathol</addtitle><date>2016-08</date><risdate>2016</risdate><volume>38</volume><issue>2</issue><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>0126-8635</issn><abstract>The risk of coronary heart disease (CHD) is dramatically increased in diabetic patients due to their atherogenic lipid profile. The severity of CHD in diabetic patients has been found to be directly associated with glycated haemoglobin (HbA1c). According to the Malaysian Clinical Practice Guidelines on diabetes mellitus (DM), HbA1c level less than 6.5% reduces the risk of microvascular and macrovascular complications. Hence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients in Hospital Putrajaya, a tertiary endocrine centre in Malaysia. This was a cross sectional, retrospective study of 214 T2DM patients with dyslipidaemia who had visited the endocrine clinic between January 2009 and December 2012. Significant correlations were found between fasting blood glucose (FBG) and HbA1c with total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL), non-high density lipoprotein cholesterol (non-HDL), LDL/HDL ratio and TC/HDL ratio; greater correlation being with HbA1c than FBG. In patients with HbA1c ≥ 6.5%, TC, TG, non-HDL and TC/HDL ratio were significantly higher than in patients with HbA1c < 6.5%. Non-HDL, LDL/HDL ratio, TC/HDL ratio and HbA1c were significantly lower in patients on statin treatment than nontreated patients (p<0.05). This significant association between glycaemic status and dyslipidaemia emphasises the additional possible use of HbA1c as a biomarker for dyslipidaemia as well as a potential indirect predictor of cardiovascular disease (CVD) risk in T2DM patients.</abstract><cop>Malaysia</cop><pub>College of Pathologists, Academy of Medicine of Malaysia</pub><pmid>27568669</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0126-8635 |
| ispartof | Malaysian journal of pathology, 2016-08, Vol.38 (2), p.123-130 |
| issn | 0126-8635 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1815371058 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Biomarkers - blood Blood Glucose - analysis Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Dyslipidemias - blood Female Glycated Hemoglobin A - analysis Glycemic Index Humans Male Middle Aged Retrospective Studies |
| title | Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T11%3A28%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20dyslipidaemia%20and%20glycaemic%20status%20in%20patients%20with%20Type%202%20diabetes%20mellitus&rft.jtitle=Malaysian%20journal%20of%20pathology&rft.au=Thambiah,%20S%20C&rft.date=2016-08&rft.volume=38&rft.issue=2&rft.spage=123&rft.epage=130&rft.pages=123-130&rft.issn=0126-8635&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1815371058%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1817563437&rft_id=info:pmid/27568669&rfr_iscdi=true |