Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis

Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and maintenance of these oncogenic client proteins are provided with Heat Shock Protein...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2016-10, Vol.122, p.280-290
Hauptverfasser:	Koca, İrfan, Özgür, Aykut, Er, Muhammet, Gümüş, Mehmet, Açikalin Coşkun, Kübra, Tutar, Yusuf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphate - metabolism Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Bone cancer Bone Neoplasms - pathology Bone Neoplasms - secondary Breast cancer Carcinoma, Ductal, Breast - pathology Cell Line, Tumor Cell Proliferation - drug effects Client proteins Drug Design Hsp90 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - chemistry Humans Hydrolysis - drug effects Molecular Docking Simulation Protein Conformation, beta-Strand Pyrimidine Thiourea Thiourea - chemical synthesis Thiourea - chemistry Thiourea - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!