Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors

A series of new (N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives (8–35) were designed, synthesized and evaluated as CDK1/Cdc2 inhibitors. Biological evaluation assays indicated that compounds 16 and 27 showed the most potent growth inhibitory activity ag...

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Veröffentlicht in:	European journal of medicinal chemistry 2016-10, Vol.122, p.164-177
Hauptverfasser:	Ganga Reddy, V., Srinivasa Reddy, T., Lakshma Nayak, V., Prasad, Budaganaboyina, Reddy, Adiyala Praveen, Ravikumar, A., Taj, Shaik, Kamal, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-cancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects CDC2 Protein Kinase - antagonists & inhibitors CDC2 Protein Kinase - chemistry CDC2 Protein Kinase - metabolism CDK1 inhibition Cell cycle Cell Line, Tumor Chemistry Techniques, Synthetic Drug Design Drug Screening Assays, Antitumor G2 Phase - drug effects Humans Molecular Docking Simulation Protein Conformation Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Pyrazole Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - metabolism Pyrazoles - pharmacology Reactive Oxygen Species - metabolism Structure-Activity Relationship
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