Baicalin Scavenged Reactive Oxygen Species and Protected Human Keratinocytes Against UVB-induced Cytotoxicity
Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. Therefore, protection against excessive UVA-induced damage is useful for preven...
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| Veröffentlicht in: | In vivo (Athens) 2016-09, Vol.30 (5), p.605-610 |
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| creator | Chang, Wen-Shin Lin, En-Yuan Hsu, Shih-Wei Hu, Pei-Shin Chuang, Chin-Liang Liao, Cheng-Hsi Fu, Chun-Kai Su, Chung-Hao Gong, Chi-Li Hsiao, Chieh-Lun Bau, DA-Tian Tsai, Chia-Wen |
| description | Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. Therefore, protection against excessive UVA-induced damage is useful for prevention of sunburn and other human diseases. Baicalin, a major component of traditional Chinese medicine Scutellaria baicalensis, has been reported to possess antioxidant and cytostatic capacities. In this study, we examined whether baicalin is also capable of protecting human keratinocytes from UVB irradiation. The results showed that baicalin effectively scavenged reactive oxygen species (ROS) elevated within 4 h after UVB radiation and reversed the UVB-suppressed cell viability and UVB-induced apoptosis after 24 h. Our results demonstrated the utility of baicalin to complement the contributions of traditional Chinese medicine in UVB-induced damage to skin and suggested their potential application as pharmaceutical agents in long-term sun-shining injury prevention. |
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Therefore, protection against excessive UVA-induced damage is useful for prevention of sunburn and other human diseases. Baicalin, a major component of traditional Chinese medicine Scutellaria baicalensis, has been reported to possess antioxidant and cytostatic capacities. In this study, we examined whether baicalin is also capable of protecting human keratinocytes from UVB irradiation. The results showed that baicalin effectively scavenged reactive oxygen species (ROS) elevated within 4 h after UVB radiation and reversed the UVB-suppressed cell viability and UVB-induced apoptosis after 24 h. Our results demonstrated the utility of baicalin to complement the contributions of traditional Chinese medicine in UVB-induced damage to skin and suggested their potential application as pharmaceutical agents in long-term sun-shining injury prevention.</description><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 27566079</identifier><language>eng</language><publisher>Greece</publisher><subject>Antioxidants - administration & dosage ; Apoptosis - drug effects ; Apoptosis - radiation effects ; Cell Line ; Cell Proliferation - drug effects ; Cell Proliferation - radiation effects ; Cell Survival - drug effects ; DNA Damage - drug effects ; Flavonoids - administration & dosage ; Humans ; Hyperpigmentation - drug therapy ; Hyperpigmentation - etiology ; Hyperpigmentation - pathology ; Keratinocytes - drug effects ; Keratinocytes - pathology ; Keratinocytes - radiation effects ; Keratosis - drug therapy ; Keratosis - etiology ; Keratosis - pathology ; Protective Agents - administration & dosage ; Reactive Oxygen Species - metabolism ; Reactive Oxygen Species - radiation effects ; Skin - drug effects ; Skin - pathology ; Skin - radiation effects ; Skin Neoplasms - drug therapy ; Skin Neoplasms - etiology ; Skin Neoplasms - pathology ; Sunburn - drug therapy ; Sunburn - etiology ; Sunburn - pathology ; Ultraviolet Rays - adverse effects</subject><ispartof>In vivo (Athens), 2016-09, Vol.30 (5), p.605-610</ispartof><rights>Copyright © 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27566079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Wen-Shin</creatorcontrib><creatorcontrib>Lin, En-Yuan</creatorcontrib><creatorcontrib>Hsu, Shih-Wei</creatorcontrib><creatorcontrib>Hu, Pei-Shin</creatorcontrib><creatorcontrib>Chuang, Chin-Liang</creatorcontrib><creatorcontrib>Liao, Cheng-Hsi</creatorcontrib><creatorcontrib>Fu, Chun-Kai</creatorcontrib><creatorcontrib>Su, Chung-Hao</creatorcontrib><creatorcontrib>Gong, Chi-Li</creatorcontrib><creatorcontrib>Hsiao, Chieh-Lun</creatorcontrib><creatorcontrib>Bau, DA-Tian</creatorcontrib><creatorcontrib>Tsai, Chia-Wen</creatorcontrib><title>Baicalin Scavenged Reactive Oxygen Species and Protected Human Keratinocytes Against UVB-induced Cytotoxicity</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. 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Our results demonstrated the utility of baicalin to complement the contributions of traditional Chinese medicine in UVB-induced damage to skin and suggested their potential application as pharmaceutical agents in long-term sun-shining injury prevention.</description><subject>Antioxidants - administration & dosage</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - radiation effects</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Proliferation - radiation effects</subject><subject>Cell Survival - drug effects</subject><subject>DNA Damage - drug effects</subject><subject>Flavonoids - administration & dosage</subject><subject>Humans</subject><subject>Hyperpigmentation - drug therapy</subject><subject>Hyperpigmentation - etiology</subject><subject>Hyperpigmentation - pathology</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - pathology</subject><subject>Keratinocytes - radiation effects</subject><subject>Keratosis - drug therapy</subject><subject>Keratosis - etiology</subject><subject>Keratosis - pathology</subject><subject>Protective Agents - administration & dosage</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reactive Oxygen Species - radiation effects</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin - radiation effects</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - etiology</subject><subject>Skin Neoplasms - pathology</subject><subject>Sunburn - drug therapy</subject><subject>Sunburn - etiology</subject><subject>Sunburn - pathology</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10E9LwzAYBvAgiJvTryA9eikkzZo0x234DwcTdV5L8ubtiLRpbdKxfnsLztNzeH48h-eCzJlULJX5Us3IdQjflApJaXZFZpnMhaBSzUmz1g507XzyAfqI_oA2eUcN0R0x2Z3GA05Nh-AwJNrb5K1vI0Kc1PPQaJ-8Yq-j8y2McRKrg3Y-xGT_tU6dtwNMbjPGNrYnBy6ON-Sy0nXA23MuyP7x4XPznG53Ty-b1TbtMsZiWlWWSsMrwQy3lDNFM8mk5Fjx3IJGYQpYGgZCFQKkosxUEgtmBOQ5WGX5gtz_7XZ9-zNgiGXjAmBda4_tEEpWsJyLpVLZRO_OdDAN2rLrXaP7sfy_iP8C8JBjIA</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Chang, Wen-Shin</creator><creator>Lin, En-Yuan</creator><creator>Hsu, Shih-Wei</creator><creator>Hu, Pei-Shin</creator><creator>Chuang, Chin-Liang</creator><creator>Liao, Cheng-Hsi</creator><creator>Fu, Chun-Kai</creator><creator>Su, Chung-Hao</creator><creator>Gong, Chi-Li</creator><creator>Hsiao, Chieh-Lun</creator><creator>Bau, DA-Tian</creator><creator>Tsai, Chia-Wen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Baicalin Scavenged Reactive Oxygen Species and Protected Human Keratinocytes Against UVB-induced Cytotoxicity</title><author>Chang, Wen-Shin ; Lin, En-Yuan ; Hsu, Shih-Wei ; Hu, Pei-Shin ; Chuang, Chin-Liang ; Liao, Cheng-Hsi ; Fu, Chun-Kai ; Su, Chung-Hao ; Gong, Chi-Li ; Hsiao, Chieh-Lun ; Bau, DA-Tian ; Tsai, Chia-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-ffd07b3f61b3d03190271773ef35dcae6b8c4b1c6986c7901bf7e81b6c55cd9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antioxidants - administration & dosage</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - radiation effects</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Proliferation - radiation effects</topic><topic>Cell Survival - drug effects</topic><topic>DNA Damage - drug effects</topic><topic>Flavonoids - administration & dosage</topic><topic>Humans</topic><topic>Hyperpigmentation - drug therapy</topic><topic>Hyperpigmentation - etiology</topic><topic>Hyperpigmentation - pathology</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - pathology</topic><topic>Keratinocytes - radiation effects</topic><topic>Keratosis - drug therapy</topic><topic>Keratosis - etiology</topic><topic>Keratosis - pathology</topic><topic>Protective Agents - administration & dosage</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Reactive Oxygen Species - radiation effects</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin - radiation effects</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - etiology</topic><topic>Skin Neoplasms - pathology</topic><topic>Sunburn - drug therapy</topic><topic>Sunburn - etiology</topic><topic>Sunburn - pathology</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Wen-Shin</creatorcontrib><creatorcontrib>Lin, En-Yuan</creatorcontrib><creatorcontrib>Hsu, Shih-Wei</creatorcontrib><creatorcontrib>Hu, Pei-Shin</creatorcontrib><creatorcontrib>Chuang, Chin-Liang</creatorcontrib><creatorcontrib>Liao, Cheng-Hsi</creatorcontrib><creatorcontrib>Fu, Chun-Kai</creatorcontrib><creatorcontrib>Su, Chung-Hao</creatorcontrib><creatorcontrib>Gong, Chi-Li</creatorcontrib><creatorcontrib>Hsiao, Chieh-Lun</creatorcontrib><creatorcontrib>Bau, DA-Tian</creatorcontrib><creatorcontrib>Tsai, Chia-Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Wen-Shin</au><au>Lin, En-Yuan</au><au>Hsu, Shih-Wei</au><au>Hu, Pei-Shin</au><au>Chuang, Chin-Liang</au><au>Liao, Cheng-Hsi</au><au>Fu, Chun-Kai</au><au>Su, Chung-Hao</au><au>Gong, Chi-Li</au><au>Hsiao, Chieh-Lun</au><au>Bau, DA-Tian</au><au>Tsai, Chia-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baicalin Scavenged Reactive Oxygen Species and Protected Human Keratinocytes Against UVB-induced Cytotoxicity</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>30</volume><issue>5</issue><spage>605</spage><epage>610</epage><pages>605-610</pages><eissn>1791-7549</eissn><abstract>Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. 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| ispartof | In vivo (Athens), 2016-09, Vol.30 (5), p.605-610 |
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| subjects | Antioxidants - administration & dosage Apoptosis - drug effects Apoptosis - radiation effects Cell Line Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell Survival - drug effects DNA Damage - drug effects Flavonoids - administration & dosage Humans Hyperpigmentation - drug therapy Hyperpigmentation - etiology Hyperpigmentation - pathology Keratinocytes - drug effects Keratinocytes - pathology Keratinocytes - radiation effects Keratosis - drug therapy Keratosis - etiology Keratosis - pathology Protective Agents - administration & dosage Reactive Oxygen Species - metabolism Reactive Oxygen Species - radiation effects Skin - drug effects Skin - pathology Skin - radiation effects Skin Neoplasms - drug therapy Skin Neoplasms - etiology Skin Neoplasms - pathology Sunburn - drug therapy Sunburn - etiology Sunburn - pathology Ultraviolet Rays - adverse effects |
| title | Baicalin Scavenged Reactive Oxygen Species and Protected Human Keratinocytes Against UVB-induced Cytotoxicity |
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