Activation or detoxification of mutagenic and carcinogenic compounds in transgenic Drosophila expressing human glutathione S-transferase

Sensitivity of transgenic Drosophila melanogaster with expression of a human gene encoding the glutathione S-transferase alpha subunit ( GSTA1-1) to 1,2:5,6-dibenzanthracene (DBA) and 1,2-dichloroethane (DCE) was investigated in the somatic mutation and recombination test (SMART). We performed the s...

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Veröffentlicht in:	Mutation research 2001-11, Vol.498 (1), p.169-179
Hauptverfasser:	Chroust, Karel, Jowett, Trevor, Farid-Wajidi, Mustafa F, Huang, Jun-Yong, Ryskova, Martina, Wolf, Roland, Holoubek, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,5,6-Dibenzanthracene 1,2-Dichloroethane Aneuploidy Animals Animals, Genetically Modified Benz(a)Anthracenes - metabolism Benz(a)Anthracenes - toxicity beta-Galactosidase - genetics Biological and medical sciences Biotransformation - drug effects Biotransformation - physiology buthionine sulfoximine Buthionine Sulfoximine - pharmacology buthionine sulphoximine Carcinogens - metabolism Carcinogens - toxicity Crosses, Genetic Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug Drosophila Drosophila melanogaster ethylene dichloride Ethylene Dichlorides - metabolism Ethylene Dichlorides - toxicity Female Female sterility Fundamental and applied biological sciences. Psychology Gene Dosage Genes. Genome Glutathione S-transferase Glutathione Transferase - genetics Glutathione Transferase - metabolism GSTA1-1 gene Humans Isoenzymes - genetics Isoenzymes - metabolism lacZ gene Larva - drug effects Larva - metabolism Male Models, Biological Molecular and cellular biology Molecular genetics Mutagenicity Tests Mutagens - metabolism Mutagens - toxicity Reproducibility of Results Transgenes Transgenic Drosophila melanogaster transgenic flies Wing spot test Wings, Animal - drug effects
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