Clinicopathological characteristics of young patients with sporadic colorectal cancer
Purpose To evaluate the clinicopathological features of and prognosis associated with sporadic colorectal cancer (CRC) in Japanese patients younger than 40 years old. Methods The subjects of this study were patients with sporadic stage 0–III CRC, who underwent curative resection between 2004 and 201...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2016-10, Vol.46 (10), p.1166-1175 |
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| creator | Murata, Asuka Akiyoshi, Takashi Ueno, Masashi Fukunaga, Yosuke Nagayama, Satoshi Fujimoto, Yoshiya Konishi, Tsuyoshi Nagasaki, Toshiya Nagata, Jun Ohno, Riki Arai, Masami Yamaguchi, Toshiharu |
| description | Purpose
To evaluate the clinicopathological features of and prognosis associated with sporadic colorectal cancer (CRC) in Japanese patients younger than 40 years old.
Methods
The subjects of this study were patients with sporadic stage 0–III CRC, who underwent curative resection between 2004 and 2012 at the Cancer Institute Hospital. Clinicopathological characteristics and survival were compared between the young ( |
| doi_str_mv | 10.1007/s00595-015-1298-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1814677474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1814677474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-59c18f026a44a803c6cbbe91e1b3d982c4639197165ca6db2b14d1fabae525753</originalsourceid><addsrcrecordid>eNp9kD1PwzAURS0EoqXwA1hQRpaAn-M49ogqvqRKLHS2nBendZXGxU6E-u9JlMLI9IZ7z5XeIeQW6ANQWjxGSnOVpxTyFJiSqTojc-CZSJmE7JzMqeIwJjAjVzHuKGVcUnpJZkwUPCskn5P1snGtQ38w3dY3fuPQNAluTTDY2eBi5zAmvk6Ovm83ydBytu1i8u26bRIPPpjKYYIDGSx2I2patOGaXNSmifbmdBdk_fL8uXxLVx-v78unVYqZkF2aKwRZUyYM50bSDAWWpVVgocwqJRlykSlQBYgcjahKVgKvoDalsTnLizxbkPtp9xD8V29jp_cuom0a01rfRw0SuCgKPny7IDBVMfgYg631Ibi9CUcNVI829WRTDzb1aFOrgbk7zffl3lZ_xK--ocCmQhyidmOD3vk-tMPL_6z-AFADgRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1814677474</pqid></control><display><type>article</type><title>Clinicopathological characteristics of young patients with sporadic colorectal cancer</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Murata, Asuka ; Akiyoshi, Takashi ; Ueno, Masashi ; Fukunaga, Yosuke ; Nagayama, Satoshi ; Fujimoto, Yoshiya ; Konishi, Tsuyoshi ; Nagasaki, Toshiya ; Nagata, Jun ; Ohno, Riki ; Arai, Masami ; Yamaguchi, Toshiharu</creator><creatorcontrib>Murata, Asuka ; Akiyoshi, Takashi ; Ueno, Masashi ; Fukunaga, Yosuke ; Nagayama, Satoshi ; Fujimoto, Yoshiya ; Konishi, Tsuyoshi ; Nagasaki, Toshiya ; Nagata, Jun ; Ohno, Riki ; Arai, Masami ; Yamaguchi, Toshiharu</creatorcontrib><description>Purpose
To evaluate the clinicopathological features of and prognosis associated with sporadic colorectal cancer (CRC) in Japanese patients younger than 40 years old.
Methods
The subjects of this study were patients with sporadic stage 0–III CRC, who underwent curative resection between 2004 and 2012 at the Cancer Institute Hospital. Clinicopathological characteristics and survival were compared between the young (<40 years;
n
= 81) and older groups (≥40 years;
n
= 2257).
Results
The median age was 36 years in the young group and 64 years in the older group. Young patients had a lower incidence of right-sided colon cancer (14 vs 28 %) and a higher incidence of rectal cancer (47 vs 32 %;
P
< 0.0001). The number of retrieved lymph nodes was significantly higher in the young group than in the older group (
P
= 0.0049). The young patients had similar overall survival and relapse-free survival to their older counterparts, except for overall survival in stage II patients (
P
= 0.0229). However, multivariate analysis indicated that age was not an independent prognostic factor for overall survival in patients with stage II CRC.
Conclusions
Young Japanese patients with sporadic CRC have unique characteristics such as a high incidence of rectal cancer and similar pathological features; however, they appear to have comparable survival to older patients.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-015-1298-9</identifier><identifier>PMID: 26743784</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Humans ; Incidence ; Japan - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Prognosis ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Surgery today (Tokyo, Japan), 2016-10, Vol.46 (10), p.1166-1175</ispartof><rights>Springer Japan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-59c18f026a44a803c6cbbe91e1b3d982c4639197165ca6db2b14d1fabae525753</citedby><cites>FETCH-LOGICAL-c368t-59c18f026a44a803c6cbbe91e1b3d982c4639197165ca6db2b14d1fabae525753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-015-1298-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-015-1298-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26743784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murata, Asuka</creatorcontrib><creatorcontrib>Akiyoshi, Takashi</creatorcontrib><creatorcontrib>Ueno, Masashi</creatorcontrib><creatorcontrib>Fukunaga, Yosuke</creatorcontrib><creatorcontrib>Nagayama, Satoshi</creatorcontrib><creatorcontrib>Fujimoto, Yoshiya</creatorcontrib><creatorcontrib>Konishi, Tsuyoshi</creatorcontrib><creatorcontrib>Nagasaki, Toshiya</creatorcontrib><creatorcontrib>Nagata, Jun</creatorcontrib><creatorcontrib>Ohno, Riki</creatorcontrib><creatorcontrib>Arai, Masami</creatorcontrib><creatorcontrib>Yamaguchi, Toshiharu</creatorcontrib><title>Clinicopathological characteristics of young patients with sporadic colorectal cancer</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
To evaluate the clinicopathological features of and prognosis associated with sporadic colorectal cancer (CRC) in Japanese patients younger than 40 years old.
Methods
The subjects of this study were patients with sporadic stage 0–III CRC, who underwent curative resection between 2004 and 2012 at the Cancer Institute Hospital. Clinicopathological characteristics and survival were compared between the young (<40 years;
n
= 81) and older groups (≥40 years;
n
= 2257).
Results
The median age was 36 years in the young group and 64 years in the older group. Young patients had a lower incidence of right-sided colon cancer (14 vs 28 %) and a higher incidence of rectal cancer (47 vs 32 %;
P
< 0.0001). The number of retrieved lymph nodes was significantly higher in the young group than in the older group (
P
= 0.0049). The young patients had similar overall survival and relapse-free survival to their older counterparts, except for overall survival in stage II patients (
P
= 0.0229). However, multivariate analysis indicated that age was not an independent prognostic factor for overall survival in patients with stage II CRC.
Conclusions
Young Japanese patients with sporadic CRC have unique characteristics such as a high incidence of rectal cancer and similar pathological features; however, they appear to have comparable survival to older patients.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EoqXwA1hQRpaAn-M49ogqvqRKLHS2nBendZXGxU6E-u9JlMLI9IZ7z5XeIeQW6ANQWjxGSnOVpxTyFJiSqTojc-CZSJmE7JzMqeIwJjAjVzHuKGVcUnpJZkwUPCskn5P1snGtQ38w3dY3fuPQNAluTTDY2eBi5zAmvk6Ovm83ydBytu1i8u26bRIPPpjKYYIDGSx2I2patOGaXNSmifbmdBdk_fL8uXxLVx-v78unVYqZkF2aKwRZUyYM50bSDAWWpVVgocwqJRlykSlQBYgcjahKVgKvoDalsTnLizxbkPtp9xD8V29jp_cuom0a01rfRw0SuCgKPny7IDBVMfgYg631Ibi9CUcNVI829WRTDzb1aFOrgbk7zffl3lZ_xK--ocCmQhyidmOD3vk-tMPL_6z-AFADgRQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Murata, Asuka</creator><creator>Akiyoshi, Takashi</creator><creator>Ueno, Masashi</creator><creator>Fukunaga, Yosuke</creator><creator>Nagayama, Satoshi</creator><creator>Fujimoto, Yoshiya</creator><creator>Konishi, Tsuyoshi</creator><creator>Nagasaki, Toshiya</creator><creator>Nagata, Jun</creator><creator>Ohno, Riki</creator><creator>Arai, Masami</creator><creator>Yamaguchi, Toshiharu</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Clinicopathological characteristics of young patients with sporadic colorectal cancer</title><author>Murata, Asuka ; Akiyoshi, Takashi ; Ueno, Masashi ; Fukunaga, Yosuke ; Nagayama, Satoshi ; Fujimoto, Yoshiya ; Konishi, Tsuyoshi ; Nagasaki, Toshiya ; Nagata, Jun ; Ohno, Riki ; Arai, Masami ; Yamaguchi, Toshiharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-59c18f026a44a803c6cbbe91e1b3d982c4639197165ca6db2b14d1fabae525753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murata, Asuka</creatorcontrib><creatorcontrib>Akiyoshi, Takashi</creatorcontrib><creatorcontrib>Ueno, Masashi</creatorcontrib><creatorcontrib>Fukunaga, Yosuke</creatorcontrib><creatorcontrib>Nagayama, Satoshi</creatorcontrib><creatorcontrib>Fujimoto, Yoshiya</creatorcontrib><creatorcontrib>Konishi, Tsuyoshi</creatorcontrib><creatorcontrib>Nagasaki, Toshiya</creatorcontrib><creatorcontrib>Nagata, Jun</creatorcontrib><creatorcontrib>Ohno, Riki</creatorcontrib><creatorcontrib>Arai, Masami</creatorcontrib><creatorcontrib>Yamaguchi, Toshiharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murata, Asuka</au><au>Akiyoshi, Takashi</au><au>Ueno, Masashi</au><au>Fukunaga, Yosuke</au><au>Nagayama, Satoshi</au><au>Fujimoto, Yoshiya</au><au>Konishi, Tsuyoshi</au><au>Nagasaki, Toshiya</au><au>Nagata, Jun</au><au>Ohno, Riki</au><au>Arai, Masami</au><au>Yamaguchi, Toshiharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological characteristics of young patients with sporadic colorectal cancer</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>46</volume><issue>10</issue><spage>1166</spage><epage>1175</epage><pages>1166-1175</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
To evaluate the clinicopathological features of and prognosis associated with sporadic colorectal cancer (CRC) in Japanese patients younger than 40 years old.
Methods
The subjects of this study were patients with sporadic stage 0–III CRC, who underwent curative resection between 2004 and 2012 at the Cancer Institute Hospital. Clinicopathological characteristics and survival were compared between the young (<40 years;
n
= 81) and older groups (≥40 years;
n
= 2257).
Results
The median age was 36 years in the young group and 64 years in the older group. Young patients had a lower incidence of right-sided colon cancer (14 vs 28 %) and a higher incidence of rectal cancer (47 vs 32 %;
P
< 0.0001). The number of retrieved lymph nodes was significantly higher in the young group than in the older group (
P
= 0.0049). The young patients had similar overall survival and relapse-free survival to their older counterparts, except for overall survival in stage II patients (
P
= 0.0229). However, multivariate analysis indicated that age was not an independent prognostic factor for overall survival in patients with stage II CRC.
Conclusions
Young Japanese patients with sporadic CRC have unique characteristics such as a high incidence of rectal cancer and similar pathological features; however, they appear to have comparable survival to older patients.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26743784</pmid><doi>10.1007/s00595-015-1298-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Colorectal Neoplasms - epidemiology Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Humans Incidence Japan - epidemiology Male Medicine Medicine & Public Health Middle Aged Original Article Prognosis Retrospective Studies Surgery Surgical Oncology Survival Rate |
| title | Clinicopathological characteristics of young patients with sporadic colorectal cancer |
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