Epinephrine Vasoconstriction Effect Time in the Scalp Differs According to Injection Site and Concentration
BACKGROUNDThere have been few studies of the action of epinephrine injected into scalp tissue, or whether the action of epinephrine differs according to vascular anatomy within the same surgical field. Effective perioperative control of bleeding is critical during hair transplantation due to its tim...
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| Veröffentlicht in: | Dermatologic surgery 2016-09, Vol.42 (9), p.1054-1060 |
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| container_title | Dermatologic surgery |
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| creator | Na, Young-Cheon Park, Raekil Jeong, Hii-Sun Park, Jae Hyun |
| description | BACKGROUNDThere have been few studies of the action of epinephrine injected into scalp tissue, or whether the action of epinephrine differs according to vascular anatomy within the same surgical field. Effective perioperative control of bleeding is critical during hair transplantation due to its time-consuming nature.
OBJECTIVETo identify the vasoconstriction time of epinephrine by concentration and injection site in the scalp tissue.
METHODSTwenty-five volunteers were injected with epinephrine at concentrations of 1:400,000, 1:200,000, 1:100,000, and 1:50,000 in the path of the supraorbital artery on the anterior hairline in the midfrontal area (Point A) and at the frontotemporal junction of the frontal hairline (Point B). Laser Doppler was used to measure scalp blood flow, and vasoconstriction time at Points A and B with each concentration of epinephrine was recorded.
RESULTSThe duration of action of epinephrine increased in direct proportion with the concentration of epinephrine. The duration of vasoconstriction was shorter at Point A than at Point B, but this difference was only statistically significant at an epinephrine concentration of 1:50,000.
CONCLUSIONThe vasoconstriction time of epinephrine in the scalp correlated positively with concentration, and the duration of vasoconstriction was longer at Point B than at Point A. |
| doi_str_mv | 10.1097/DSS.0000000000000845 |
| format | Article |
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OBJECTIVETo identify the vasoconstriction time of epinephrine by concentration and injection site in the scalp tissue.
METHODSTwenty-five volunteers were injected with epinephrine at concentrations of 1:400,000, 1:200,000, 1:100,000, and 1:50,000 in the path of the supraorbital artery on the anterior hairline in the midfrontal area (Point A) and at the frontotemporal junction of the frontal hairline (Point B). Laser Doppler was used to measure scalp blood flow, and vasoconstriction time at Points A and B with each concentration of epinephrine was recorded.
RESULTSThe duration of action of epinephrine increased in direct proportion with the concentration of epinephrine. The duration of vasoconstriction was shorter at Point A than at Point B, but this difference was only statistically significant at an epinephrine concentration of 1:50,000.
CONCLUSIONThe vasoconstriction time of epinephrine in the scalp correlated positively with concentration, and the duration of vasoconstriction was longer at Point B than at Point A.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1097/DSS.0000000000000845</identifier><identifier>PMID: 27465250</identifier><language>eng</language><publisher>United States: by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Epinephrine - administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Regional Blood Flow - drug effects ; Scalp - blood supply ; Time Factors ; Ultrasonography, Doppler ; Vasoconstriction - drug effects ; Vasoconstrictor Agents - administration & dosage ; Young Adult</subject><ispartof>Dermatologic surgery, 2016-09, Vol.42 (9), p.1054-1060</ispartof><rights>2016 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3565-816c4de030e7c7cc2c47e1f04890d16ffe40d35809aad35e11fe95c940092bba3</citedby><cites>FETCH-LOGICAL-c3565-816c4de030e7c7cc2c47e1f04890d16ffe40d35809aad35e11fe95c940092bba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27465250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Na, Young-Cheon</creatorcontrib><creatorcontrib>Park, Raekil</creatorcontrib><creatorcontrib>Jeong, Hii-Sun</creatorcontrib><creatorcontrib>Park, Jae Hyun</creatorcontrib><title>Epinephrine Vasoconstriction Effect Time in the Scalp Differs According to Injection Site and Concentration</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>BACKGROUNDThere have been few studies of the action of epinephrine injected into scalp tissue, or whether the action of epinephrine differs according to vascular anatomy within the same surgical field. Effective perioperative control of bleeding is critical during hair transplantation due to its time-consuming nature.
OBJECTIVETo identify the vasoconstriction time of epinephrine by concentration and injection site in the scalp tissue.
METHODSTwenty-five volunteers were injected with epinephrine at concentrations of 1:400,000, 1:200,000, 1:100,000, and 1:50,000 in the path of the supraorbital artery on the anterior hairline in the midfrontal area (Point A) and at the frontotemporal junction of the frontal hairline (Point B). Laser Doppler was used to measure scalp blood flow, and vasoconstriction time at Points A and B with each concentration of epinephrine was recorded.
RESULTSThe duration of action of epinephrine increased in direct proportion with the concentration of epinephrine. The duration of vasoconstriction was shorter at Point A than at Point B, but this difference was only statistically significant at an epinephrine concentration of 1:50,000.
CONCLUSIONThe vasoconstriction time of epinephrine in the scalp correlated positively with concentration, and the duration of vasoconstriction was longer at Point B than at Point A.</description><subject>Adult</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Epinephrine - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Regional Blood Flow - drug effects</subject><subject>Scalp - blood supply</subject><subject>Time Factors</subject><subject>Ultrasonography, Doppler</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictor Agents - administration & dosage</subject><subject>Young Adult</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEYmPwDxDKkUvBaZN-HKdtfEhIHDa4VlnqskCXlCTTxL8naAMhDvhgW_b72tJDyDmDKwZVcT2dz6_gd5RcHJAhEylPeJGKw9hDkScgWDogJ96_ArC0yuCYDNKC5yIVMCRvs14b7FcuZvosvVXW-OC0CtoaOmtbVIEu9BqpNjSskM6V7Ho61XHjPB0rZV2jzQsNlt6bV9z55joglaahE2sUmuDk1_iUHLWy83i2ryPydDNbTO6Sh8fb-8n4IVGZyEVSslzxBiEDLFShVKp4gawFXlbQsDw-5tBkooRKyliRsRYroSoOUKXLpcxG5HJ3t3f2fYM-1GvtFXadNGg3vmYl43khyghjRPhOqpz13mFb906vpfuoGdRfmOuIuf6LOdou9h82yzU2P6ZvrlFQ7gRb24UI6q3bbNHVK5RdWP1_-xNi74nl</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Na, Young-Cheon</creator><creator>Park, Raekil</creator><creator>Jeong, Hii-Sun</creator><creator>Park, Jae Hyun</creator><general>by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Epinephrine Vasoconstriction Effect Time in the Scalp Differs According to Injection Site and Concentration</title><author>Na, Young-Cheon ; Park, Raekil ; Jeong, Hii-Sun ; Park, Jae Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3565-816c4de030e7c7cc2c47e1f04890d16ffe40d35809aad35e11fe95c940092bba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Epinephrine - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Regional Blood Flow - drug effects</topic><topic>Scalp - blood supply</topic><topic>Time Factors</topic><topic>Ultrasonography, Doppler</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstrictor Agents - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Na, Young-Cheon</creatorcontrib><creatorcontrib>Park, Raekil</creatorcontrib><creatorcontrib>Jeong, Hii-Sun</creatorcontrib><creatorcontrib>Park, Jae Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Na, Young-Cheon</au><au>Park, Raekil</au><au>Jeong, Hii-Sun</au><au>Park, Jae Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epinephrine Vasoconstriction Effect Time in the Scalp Differs According to Injection Site and Concentration</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2016-09</date><risdate>2016</risdate><volume>42</volume><issue>9</issue><spage>1054</spage><epage>1060</epage><pages>1054-1060</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>BACKGROUNDThere have been few studies of the action of epinephrine injected into scalp tissue, or whether the action of epinephrine differs according to vascular anatomy within the same surgical field. Effective perioperative control of bleeding is critical during hair transplantation due to its time-consuming nature.
OBJECTIVETo identify the vasoconstriction time of epinephrine by concentration and injection site in the scalp tissue.
METHODSTwenty-five volunteers were injected with epinephrine at concentrations of 1:400,000, 1:200,000, 1:100,000, and 1:50,000 in the path of the supraorbital artery on the anterior hairline in the midfrontal area (Point A) and at the frontotemporal junction of the frontal hairline (Point B). Laser Doppler was used to measure scalp blood flow, and vasoconstriction time at Points A and B with each concentration of epinephrine was recorded.
RESULTSThe duration of action of epinephrine increased in direct proportion with the concentration of epinephrine. The duration of vasoconstriction was shorter at Point A than at Point B, but this difference was only statistically significant at an epinephrine concentration of 1:50,000.
CONCLUSIONThe vasoconstriction time of epinephrine in the scalp correlated positively with concentration, and the duration of vasoconstriction was longer at Point B than at Point A.</abstract><cop>United States</cop><pub>by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27465250</pmid><doi>10.1097/DSS.0000000000000845</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Dose-Response Relationship, Drug Double-Blind Method Epinephrine - administration & dosage Female Humans Male Middle Aged Regional Blood Flow - drug effects Scalp - blood supply Time Factors Ultrasonography, Doppler Vasoconstriction - drug effects Vasoconstrictor Agents - administration & dosage Young Adult |
| title | Epinephrine Vasoconstriction Effect Time in the Scalp Differs According to Injection Site and Concentration |
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