Simvastatin Inhibits Epithelial-to-Mesenchymal Transition Through Induction of HO-1 in Cultured Renal Proximal Tubule Cells

Studies have shown that simvastatin (SIM) inhibits epithelial-mesenchymal transition (EMT), a key step in fibrosis, and activates the anti-fibrotic heme oxygenase-1 (HO-1) gene in renal proximal tubule cells independent of its lipid-lowering. We tested the hypothesis that SIM inhibits EMT via HO-1-d...

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Veröffentlicht in:	In vivo (Athens) 2016-07, Vol.30 (4), p.407-411
Hauptverfasser:	Clark, Jeb S, Carter, Anthony J, Dixit, Mehul, Arany, Istvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Cells, Cultured Epithelial-Mesenchymal Transition - drug effects Gene Expression Regulation, Enzymologic - drug effects Heme Oxygenase-1 - metabolism Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Reactive Oxygen Species - metabolism Simvastatin - pharmacology Swine Transforming Growth Factor beta1 - pharmacology
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