Deletion of LR11 Attenuates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation With Medial Thickening in Mice

OBJECTIVE—We aimed to determine whether LR11 (low-density lipoprotein receptor with 11 binding repeats) is a potential key regulator of smooth muscle cell (SMC) proliferation during the progression of hypoxia-induced medial thickening in mice and whether sLR11 (soluble LR11) can serve as a biomarker...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-09, Vol.36 (9), p.1972-1979
Hauptverfasser:	Jiang, Le, Konishi, Hakuoh, Nurwidya, Fariz, Satoh, Kimio, Takahashi, Fumiyuki, Ebinuma, Hiroyuki, Fujimura, Kengo, Takasu, Kiyoshi, Jiang, Meizi, Shimokawa, Hiroaki, Bujo, Hideaki, Daida, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial Pressure Cell Proliferation Cells, Cultured Genotype Humans Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypertension, Pulmonary - prevention & control Hypertrophy, Right Ventricular - metabolism Hypertrophy, Right Ventricular - prevention & control Hypoxia - complications Hypoxia - genetics Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism LDL-Receptor Related Proteins - metabolism Membrane Transport Proteins - deficiency Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - metabolism Neointima Phenotype Pulmonary Artery - metabolism Pulmonary Artery - pathology Pulmonary Artery - physiopathology Receptors, LDL - deficiency Receptors, LDL - genetics Signal Transduction Transfection Vascular Remodeling Vascular Resistance Ventricular Dysfunction, Right - metabolism Ventricular Dysfunction, Right - prevention & control Ventricular Function, Right Ventricular Pressure
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