Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer

Abstract Objective Radiation-induced mucositis (RIM) in chemoradiotherapy (CRT) for head and neck cancer (HNC) causes severe pain and worsens CRT compliance, QOL and outcome. Following retrospective reports, we conducted a randomized trial of the safety and efficacy of gabapentin for RIM-associated...

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Veröffentlicht in:	Auris, nasus, larynx nasus, larynx, 2016-12, Vol.43 (6), p.677-684
Hauptverfasser:	Kataoka, Tomoko, Kiyota, Naomi, Shimada, Takanobu, Funakoshi, Yohei, Chayahara, Naoko, Toyoda, Masanori, Fujiwara, Yutaka, Nibu, Ken-ichi, Komori, Takahide, Sasaki, Ryohei, Mukohara, Toru, Minami, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - therapeutic use Adult Aged Amines - therapeutic use Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Antineoplastic Agents - therapeutic use Carcinoma, Squamous Cell - therapy Chemoradiotherapy Chemoradiotherapy - adverse effects Cisplatin - therapeutic use Cyclohexanecarboxylic Acids - therapeutic use Drug Therapy, Combination Female Gabapentin gamma-Aminobutyric Acid - therapeutic use Head and neck cancer Head and Neck Neoplasms - therapy Humans Male Middle Aged Otolaryngology Pain - drug therapy Pain - etiology Pain Management Radiation Injuries - drug therapy Radiation Injuries - etiology Radiation-induced mucositis Radiotherapy - adverse effects Squamous Cell Carcinoma of Head and Neck Stomatitis - drug therapy Stomatitis - etiology
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