Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure

In cardiac hypertrophy (CH) and heart failure (HF), alterations occur in mitochondrial enzyme content and activities but the origin and implications of these changes for mitochondrial function need to be resolved. Right ventricular CH or HF was induced by monocrotaline injection, which causes pulmon...

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Veröffentlicht in:	Cardiovascular research 2016-09, Vol.111 (4), p.362-372
Hauptverfasser:	Wüst, Rob C I, de Vries, Heder J, Wintjes, Liesbeth T, Rodenburg, Richard J, Niessen, Hans W M, Stienen, Ger J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - metabolism Disease Models, Animal Heart - physiopathology Hypertrophy, Right Ventricular - metabolism Male Mitochondria - metabolism Myocardium - metabolism NAD - metabolism NADP - metabolism Oxygen Consumption - physiology Rats, Wistar
Online-Zugang:	Volltext
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