Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species

Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidat...

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Veröffentlicht in:Journal of natural medicines 2016-10, Vol.70 (4), p.769-779
Hauptverfasser: Tamrakar, Sonam, Tran, Hai Bang, Nishida, Marina, Kaifuchi, Satoru, Suhara, Hiroto, Doi, Katsumi, Fukami, Katsuya, Parajuli, Gopal Prasad, Shimizu, Kuniyoshi
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container_end_page 779
container_issue 4
container_start_page 769
container_title Journal of natural medicines
container_volume 70
creator Tamrakar, Sonam
Tran, Hai Bang
Nishida, Marina
Kaifuchi, Satoru
Suhara, Hiroto
Doi, Katsumi
Fukami, Katsuya
Parajuli, Gopal Prasad
Shimizu, Kuniyoshi
description Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidative properties of Nepalese wild mushrooms. Sixty-two wild mushroom samples were collected from several forests in different parts of Nepal. Ethanol and water extracts of the dried samples were tested for their antioxidative activities using total phenolic content (TPC), oxygen radical absorbance capacity (ORAC) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and reducing power (RP) assays. Ethanol extracts of samples belonging to the order Hymenochaetales showed significantly high activity in all the assays. Inonotus clemensiae had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC 50 values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC 0.5 value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. These findings highlight the very strong antioxidative activity of Nepalese mushrooms, and paves the way for further research to explore their economic potential.
doi_str_mv 10.1007/s11418-016-1013-1
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Inonotus clemensiae had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC 50 values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC 0.5 value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. 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Inonotus clemensiae had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC 50 values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC 0.5 value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. 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subjects Agaricales - chemistry
Antioxidants - analysis
Antioxidants - pharmacology
Benzothiazoles - metabolism
Biological Products - chemistry
Biological Products - pharmacology
Biomedical and Life Sciences
Biomedicine
Biphenyl Compounds - metabolism
Chromatography
Chromatography, High Pressure Liquid
Complementary & Alternative Medicine
Fungi - chemistry
Medicinal Chemistry
Mushrooms
Nepal
Original Paper
Oxidation-Reduction
Pharmacology/Toxicology
Pharmacy
Phenols - analysis
Phenols - pharmacology
Phytochemicals
Picrates - metabolism
Plant Sciences
Sulfonic Acids - metabolism
title Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species
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