Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species
Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidat...
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container_title | Journal of natural medicines |
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creator | Tamrakar, Sonam Tran, Hai Bang Nishida, Marina Kaifuchi, Satoru Suhara, Hiroto Doi, Katsumi Fukami, Katsuya Parajuli, Gopal Prasad Shimizu, Kuniyoshi |
description | Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidative properties of Nepalese wild mushrooms. Sixty-two wild mushroom samples were collected from several forests in different parts of Nepal. Ethanol and water extracts of the dried samples were tested for their antioxidative activities using total phenolic content (TPC), oxygen radical absorbance capacity (ORAC) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and reducing power (RP) assays. Ethanol extracts of samples belonging to the order Hymenochaetales showed significantly high activity in all the assays.
Inonotus clemensiae
had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC
50
values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC
0.5
value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. These findings highlight the very strong antioxidative activity of Nepalese mushrooms, and paves the way for further research to explore their economic potential. |
doi_str_mv | 10.1007/s11418-016-1013-1 |
format | Article |
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Inonotus clemensiae
had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC
50
values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC
0.5
value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. These findings highlight the very strong antioxidative activity of Nepalese mushrooms, and paves the way for further research to explore their economic potential.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-016-1013-1</identifier><identifier>PMID: 27262299</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Agaricales - chemistry ; Antioxidants - analysis ; Antioxidants - pharmacology ; Benzothiazoles - metabolism ; Biological Products - chemistry ; Biological Products - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Biphenyl Compounds - metabolism ; Chromatography ; Chromatography, High Pressure Liquid ; Complementary & Alternative Medicine ; Fungi - chemistry ; Medicinal Chemistry ; Mushrooms ; Nepal ; Original Paper ; Oxidation-Reduction ; Pharmacology/Toxicology ; Pharmacy ; Phenols - analysis ; Phenols - pharmacology ; Phytochemicals ; Picrates - metabolism ; Plant Sciences ; Sulfonic Acids - metabolism</subject><ispartof>Journal of natural medicines, 2016-10, Vol.70 (4), p.769-779</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan 2016</rights><rights>Copyright Springer Science & Business Media 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-ca5b9eafe4192876d5fde6f0ab5082519229fc19888d63838743c49e406b36f23</citedby><cites>FETCH-LOGICAL-c489t-ca5b9eafe4192876d5fde6f0ab5082519229fc19888d63838743c49e406b36f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-016-1013-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-016-1013-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27262299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamrakar, Sonam</creatorcontrib><creatorcontrib>Tran, Hai Bang</creatorcontrib><creatorcontrib>Nishida, Marina</creatorcontrib><creatorcontrib>Kaifuchi, Satoru</creatorcontrib><creatorcontrib>Suhara, Hiroto</creatorcontrib><creatorcontrib>Doi, Katsumi</creatorcontrib><creatorcontrib>Fukami, Katsuya</creatorcontrib><creatorcontrib>Parajuli, Gopal Prasad</creatorcontrib><creatorcontrib>Shimizu, Kuniyoshi</creatorcontrib><title>Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidative properties of Nepalese wild mushrooms. Sixty-two wild mushroom samples were collected from several forests in different parts of Nepal. Ethanol and water extracts of the dried samples were tested for their antioxidative activities using total phenolic content (TPC), oxygen radical absorbance capacity (ORAC) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and reducing power (RP) assays. Ethanol extracts of samples belonging to the order Hymenochaetales showed significantly high activity in all the assays.
Inonotus clemensiae
had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC
50
values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC
0.5
value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. These findings highlight the very strong antioxidative activity of Nepalese mushrooms, and paves the way for further research to explore their economic potential.</description><subject>Agaricales - chemistry</subject><subject>Antioxidants - analysis</subject><subject>Antioxidants - pharmacology</subject><subject>Benzothiazoles - metabolism</subject><subject>Biological Products - chemistry</subject><subject>Biological Products - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biphenyl Compounds - metabolism</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Complementary & Alternative Medicine</subject><subject>Fungi - chemistry</subject><subject>Medicinal Chemistry</subject><subject>Mushrooms</subject><subject>Nepal</subject><subject>Original Paper</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phenols - analysis</subject><subject>Phenols - pharmacology</subject><subject>Phytochemicals</subject><subject>Picrates - metabolism</subject><subject>Plant Sciences</subject><subject>Sulfonic Acids - metabolism</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQha2Kii0LP6AXZIlLLwGP7XjtY1VBQaropZwtrzPuepXEwU6A_nu82i1CSJxmNP7em5EfIZfA3gNjmw8FQIJuGKgGGIgGzsgFaAUN40a8qL2QrBFSihV5VcqeMcmFgJdkxTdccW7MBdlfj3NMv2Ln5vgDqfO1xDlioSlQxenP2Hd0WMoupzQUGnIa6FecXE_d2NF5h3Ta4Zj66OmUU4g9HoQlDUgL9uhn7GiZ0FfH1-Q8uL7gm1Ndk2-fPj7cfG7u7m-_3FzfNV5qMzfetVuDLqAEw_VGdW3oUAXmti3TvK1DboIHo7XulNBCb6Tw0qBkaitU4GJNro6-9aDvC5bZDrF47Hs3YlqKBQ1StYqDqui7f9B9WvJYr6uUZlqDEaxScKR8TqVkDHbKcXD5yQKzhyDsMQhbg7CHICxUzduT87IdsPujeP75CvAjUOrT-Ij5r9X_df0NBMSSeg</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Tamrakar, Sonam</creator><creator>Tran, Hai Bang</creator><creator>Nishida, Marina</creator><creator>Kaifuchi, Satoru</creator><creator>Suhara, Hiroto</creator><creator>Doi, Katsumi</creator><creator>Fukami, Katsuya</creator><creator>Parajuli, Gopal Prasad</creator><creator>Shimizu, Kuniyoshi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species</title><author>Tamrakar, Sonam ; Tran, Hai Bang ; Nishida, Marina ; Kaifuchi, Satoru ; Suhara, Hiroto ; Doi, Katsumi ; Fukami, Katsuya ; Parajuli, Gopal Prasad ; Shimizu, Kuniyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-ca5b9eafe4192876d5fde6f0ab5082519229fc19888d63838743c49e406b36f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Agaricales - chemistry</topic><topic>Antioxidants - analysis</topic><topic>Antioxidants - pharmacology</topic><topic>Benzothiazoles - metabolism</topic><topic>Biological Products - chemistry</topic><topic>Biological Products - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biphenyl Compounds - metabolism</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Complementary & Alternative Medicine</topic><topic>Fungi - chemistry</topic><topic>Medicinal Chemistry</topic><topic>Mushrooms</topic><topic>Nepal</topic><topic>Original Paper</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phenols - analysis</topic><topic>Phenols - pharmacology</topic><topic>Phytochemicals</topic><topic>Picrates - metabolism</topic><topic>Plant Sciences</topic><topic>Sulfonic Acids - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamrakar, Sonam</creatorcontrib><creatorcontrib>Tran, Hai Bang</creatorcontrib><creatorcontrib>Nishida, Marina</creatorcontrib><creatorcontrib>Kaifuchi, Satoru</creatorcontrib><creatorcontrib>Suhara, Hiroto</creatorcontrib><creatorcontrib>Doi, Katsumi</creatorcontrib><creatorcontrib>Fukami, Katsuya</creatorcontrib><creatorcontrib>Parajuli, Gopal Prasad</creatorcontrib><creatorcontrib>Shimizu, Kuniyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamrakar, Sonam</au><au>Tran, Hai Bang</au><au>Nishida, Marina</au><au>Kaifuchi, Satoru</au><au>Suhara, Hiroto</au><au>Doi, Katsumi</au><au>Fukami, Katsuya</au><au>Parajuli, Gopal Prasad</au><au>Shimizu, Kuniyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>70</volume><issue>4</issue><spage>769</spage><epage>779</epage><pages>769-779</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidative properties of Nepalese wild mushrooms. Sixty-two wild mushroom samples were collected from several forests in different parts of Nepal. Ethanol and water extracts of the dried samples were tested for their antioxidative activities using total phenolic content (TPC), oxygen radical absorbance capacity (ORAC) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and reducing power (RP) assays. Ethanol extracts of samples belonging to the order Hymenochaetales showed significantly high activity in all the assays.
Inonotus clemensiae
had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC
50
values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC
0.5
value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography–mass spectrometry (LC–MS) analysis for some unknown compounds. These findings highlight the very strong antioxidative activity of Nepalese mushrooms, and paves the way for further research to explore their economic potential.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27262299</pmid><doi>10.1007/s11418-016-1013-1</doi><tpages>11</tpages></addata></record> |
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subjects | Agaricales - chemistry Antioxidants - analysis Antioxidants - pharmacology Benzothiazoles - metabolism Biological Products - chemistry Biological Products - pharmacology Biomedical and Life Sciences Biomedicine Biphenyl Compounds - metabolism Chromatography Chromatography, High Pressure Liquid Complementary & Alternative Medicine Fungi - chemistry Medicinal Chemistry Mushrooms Nepal Original Paper Oxidation-Reduction Pharmacology/Toxicology Pharmacy Phenols - analysis Phenols - pharmacology Phytochemicals Picrates - metabolism Plant Sciences Sulfonic Acids - metabolism |
title | Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species |
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