High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry

•A high throughput UPC2-MS/MS method for the analysis of 19 steroids is described.•UPC2-MS/MS offers superior selectivity and increased chromatographic efficiency.•Significant improvements in sensitivity were achieved by UPC2-MS/MS.•UPC2-MS/MS is a SFC based technology which is ideal for steroid ana...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2016-09, Vol.1031, p.131-138
Hauptverfasser:	Quanson, Jonathan L., Stander, Marietjie A., Pretorius, Elzette, Jenkinson, Carl, Taylor, Angela E., Storbeck, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal androgens Androgens - analysis Chromatography, Liquid - methods Chromatography, Supercritical Fluid - methods Gas chromatography High-Throughput Screening Assays Humans Reference Standards Reproducibility of Results Steroids Supercritical fluid chromatography Tandem Mass Spectrometry - methods Ultra performance convergence chromatography Ultra performance liquid chromatography
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