Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives
Blood coagulation parameters (thromboplastin time, PT; activated partial thromboplastin time, aPTT; fibrinogen; antithrombin III, ATIII; von Willebrand factor-concentration, vWF; factor VIII-activity, FVIII) and fibrinolytic parameters (plasminogen; (α-antiplasmin; euglobulin-lysis- time, Elt; tissu...
Gespeichert in:
| Veröffentlicht in: | Journal of science and medicine in sport 2000-12, Vol.3 (4), p.383-390 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 390 |
|---|---|
| container_issue | 4 |
| container_start_page | 383 |
| container_title | Journal of science and medicine in sport |
| container_volume | 3 |
| creator | Hilberg, Thomas Nowacki, Paul E Müller-Berghaus, Gert Gabriel, Holger H.W. |
| description | Blood coagulation parameters (thromboplastin time, PT; activated partial thromboplastin time, aPTT; fibrinogen; antithrombin III, ATIII; von Willebrand factor-concentration, vWF; factor VIII-activity, FVIII) and fibrinolytic parameters (plasminogen; (α-antiplasmin; euglobulin-lysis- time, Elt; tissue plasminogenactivator-antigen, tPA-antigen; plasminogenactivator-1-antigen, PAI-1-antigen) were evaluated in 34 women on low-dose oral contraceptives (OC) twice at intervals of 12 weeks each time before and after maximal exercise. During the 12 weeks, 24 women took part in an aerobic conditioning program and 10 women were requested to avoid any kind of sports activity for this period. Blood samples were taken before training and before and after maximal treadmill exercise. This procedure was repeated after the training program. After maximal exercise we found a significant reduction of aPTT and PT (increase in %), a decrease in ATIII, vWF, fibrinogen, plasminogen and α
2-antiplasmin but an increase in fibrinolytic activity (all p |
| doi_str_mv | 10.1016/S1440-2440(00)80005-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18143079</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1440244000800055</els_id><sourcerecordid>18143079</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-e52c963efb90081ef64610728d223bbcbb47c1045d3b17afe8db9a29fe1b71db3</originalsourceid><addsrcrecordid>eNqFkctuFDEQRS0EIiHwCSCvECwaynY_Vyga8ZIiZRFYW35Uzxi67cH2ZJIPyf_GPTOIJRuXXTq3rsqXkNcMPjBg7ccbVtdQ8XK8A3jfA0BTNU_IOeu7vmJ9y56W-1_kjLxI6RcAbzrRPSdnjHHRANTn5GG1UX6NiTpP9RSCpSao9W5S2QVPlbd0dDo6H6b75BJVKQXjVEZL9y5v6Kzu3KwmincYjUt4UGw3hTWla4K3bhnk_Hox2IcZPc3q9_Kewp7aUCQhHtEclcFtdreYXpJno5oSvjrVC_Lzy-cfq2_V1fXX76vLq8oIwXOFDTdDK3DUA0DPcGzrlkHHe8u50NpoXXeGQd1YoVmnRuytHhQfRmS6Y1aLC_L2OHcbw58dpixnlwxOk_IYdkmyntUCuqGAzRE0MaQUcZTbWBaP95KBXPKQhzzk8tkSQB7ykE3RvTkZ7PSM9p_qFEABPh0BLGveOowyGYfeoHURTZY2uP9YPAL5wp5u</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18143079</pqid></control><display><type>article</type><title>Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Hilberg, Thomas ; Nowacki, Paul E ; Müller-Berghaus, Gert ; Gabriel, Holger H.W.</creator><creatorcontrib>Hilberg, Thomas ; Nowacki, Paul E ; Müller-Berghaus, Gert ; Gabriel, Holger H.W.</creatorcontrib><description>Blood coagulation parameters (thromboplastin time, PT; activated partial thromboplastin time, aPTT; fibrinogen; antithrombin III, ATIII; von Willebrand factor-concentration, vWF; factor VIII-activity, FVIII) and fibrinolytic parameters (plasminogen; (α-antiplasmin; euglobulin-lysis- time, Elt; tissue plasminogenactivator-antigen, tPA-antigen; plasminogenactivator-1-antigen, PAI-1-antigen) were evaluated in 34 women on low-dose oral contraceptives (OC) twice at intervals of 12 weeks each time before and after maximal exercise. During the 12 weeks, 24 women took part in an aerobic conditioning program and 10 women were requested to avoid any kind of sports activity for this period. Blood samples were taken before training and before and after maximal treadmill exercise. This procedure was repeated after the training program. After maximal exercise we found a significant reduction of aPTT and PT (increase in %), a decrease in ATIII, vWF, fibrinogen, plasminogen and α
2-antiplasmin but an increase in fibrinolytic activity (all p<0,05). Maximal exercise is associated with an increase in blood coagulation and fibrinolysis also in women taking OC. After the physical conditioning program an increase in fibrinolytic activity at rest was noted in the training group. Opposed to that the fibrinolytic activity at rest decreased in the control group after abstinence of sports activity over this period (p<0,05, MANOVA).</description><identifier>ISSN: 1440-2440</identifier><identifier>EISSN: 1878-1861</identifier><identifier>DOI: 10.1016/S1440-2440(00)80005-5</identifier><identifier>PMID: 11235004</identifier><language>eng</language><publisher>Australia: Elsevier Ltd</publisher><subject>Adult ; Analysis of Variance ; Blood Coagulation - drug effects ; Blood Coagulation - physiology ; Conditioning (Psychology) - physiology ; Contraceptives, Oral, Combined - administration & dosage ; Contraceptives, Oral, Hormonal - administration & dosage ; Desogestrel - administration & dosage ; Dose-Response Relationship, Drug ; Ethinyl Estradiol - administration & dosage ; Exercise Test ; Female ; Fibrinolysis - drug effects ; Fibrinolysis - physiology ; Humans ; Levonorgestrel - administration & dosage ; Physical Education and Training ; Physical Exertion - physiology ; Probability ; Reference Values ; Thrombophilia - chemically induced ; Thrombophilia - physiopathology</subject><ispartof>Journal of science and medicine in sport, 2000-12, Vol.3 (4), p.383-390</ispartof><rights>2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-e52c963efb90081ef64610728d223bbcbb47c1045d3b17afe8db9a29fe1b71db3</citedby><cites>FETCH-LOGICAL-c332t-e52c963efb90081ef64610728d223bbcbb47c1045d3b17afe8db9a29fe1b71db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1440-2440(00)80005-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11235004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hilberg, Thomas</creatorcontrib><creatorcontrib>Nowacki, Paul E</creatorcontrib><creatorcontrib>Müller-Berghaus, Gert</creatorcontrib><creatorcontrib>Gabriel, Holger H.W.</creatorcontrib><title>Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives</title><title>Journal of science and medicine in sport</title><addtitle>J Sci Med Sport</addtitle><description>Blood coagulation parameters (thromboplastin time, PT; activated partial thromboplastin time, aPTT; fibrinogen; antithrombin III, ATIII; von Willebrand factor-concentration, vWF; factor VIII-activity, FVIII) and fibrinolytic parameters (plasminogen; (α-antiplasmin; euglobulin-lysis- time, Elt; tissue plasminogenactivator-antigen, tPA-antigen; plasminogenactivator-1-antigen, PAI-1-antigen) were evaluated in 34 women on low-dose oral contraceptives (OC) twice at intervals of 12 weeks each time before and after maximal exercise. During the 12 weeks, 24 women took part in an aerobic conditioning program and 10 women were requested to avoid any kind of sports activity for this period. Blood samples were taken before training and before and after maximal treadmill exercise. This procedure was repeated after the training program. After maximal exercise we found a significant reduction of aPTT and PT (increase in %), a decrease in ATIII, vWF, fibrinogen, plasminogen and α
2-antiplasmin but an increase in fibrinolytic activity (all p<0,05). Maximal exercise is associated with an increase in blood coagulation and fibrinolysis also in women taking OC. After the physical conditioning program an increase in fibrinolytic activity at rest was noted in the training group. Opposed to that the fibrinolytic activity at rest decreased in the control group after abstinence of sports activity over this period (p<0,05, MANOVA).</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood Coagulation - physiology</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Contraceptives, Oral, Combined - administration & dosage</subject><subject>Contraceptives, Oral, Hormonal - administration & dosage</subject><subject>Desogestrel - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethinyl Estradiol - administration & dosage</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fibrinolysis - drug effects</subject><subject>Fibrinolysis - physiology</subject><subject>Humans</subject><subject>Levonorgestrel - administration & dosage</subject><subject>Physical Education and Training</subject><subject>Physical Exertion - physiology</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Thrombophilia - chemically induced</subject><subject>Thrombophilia - physiopathology</subject><issn>1440-2440</issn><issn>1878-1861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuFDEQRS0EIiHwCSCvECwaynY_Vyga8ZIiZRFYW35Uzxi67cH2ZJIPyf_GPTOIJRuXXTq3rsqXkNcMPjBg7ccbVtdQ8XK8A3jfA0BTNU_IOeu7vmJ9y56W-1_kjLxI6RcAbzrRPSdnjHHRANTn5GG1UX6NiTpP9RSCpSao9W5S2QVPlbd0dDo6H6b75BJVKQXjVEZL9y5v6Kzu3KwmincYjUt4UGw3hTWla4K3bhnk_Hox2IcZPc3q9_Kewp7aUCQhHtEclcFtdreYXpJno5oSvjrVC_Lzy-cfq2_V1fXX76vLq8oIwXOFDTdDK3DUA0DPcGzrlkHHe8u50NpoXXeGQd1YoVmnRuytHhQfRmS6Y1aLC_L2OHcbw58dpixnlwxOk_IYdkmyntUCuqGAzRE0MaQUcZTbWBaP95KBXPKQhzzk8tkSQB7ykE3RvTkZ7PSM9p_qFEABPh0BLGveOowyGYfeoHURTZY2uP9YPAL5wp5u</recordid><startdate>200012</startdate><enddate>200012</enddate><creator>Hilberg, Thomas</creator><creator>Nowacki, Paul E</creator><creator>Müller-Berghaus, Gert</creator><creator>Gabriel, Holger H.W.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope></search><sort><creationdate>200012</creationdate><title>Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives</title><author>Hilberg, Thomas ; Nowacki, Paul E ; Müller-Berghaus, Gert ; Gabriel, Holger H.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-e52c963efb90081ef64610728d223bbcbb47c1045d3b17afe8db9a29fe1b71db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood Coagulation - physiology</topic><topic>Conditioning (Psychology) - physiology</topic><topic>Contraceptives, Oral, Combined - administration & dosage</topic><topic>Contraceptives, Oral, Hormonal - administration & dosage</topic><topic>Desogestrel - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethinyl Estradiol - administration & dosage</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fibrinolysis - drug effects</topic><topic>Fibrinolysis - physiology</topic><topic>Humans</topic><topic>Levonorgestrel - administration & dosage</topic><topic>Physical Education and Training</topic><topic>Physical Exertion - physiology</topic><topic>Probability</topic><topic>Reference Values</topic><topic>Thrombophilia - chemically induced</topic><topic>Thrombophilia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilberg, Thomas</creatorcontrib><creatorcontrib>Nowacki, Paul E</creatorcontrib><creatorcontrib>Müller-Berghaus, Gert</creatorcontrib><creatorcontrib>Gabriel, Holger H.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><jtitle>Journal of science and medicine in sport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilberg, Thomas</au><au>Nowacki, Paul E</au><au>Müller-Berghaus, Gert</au><au>Gabriel, Holger H.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives</atitle><jtitle>Journal of science and medicine in sport</jtitle><addtitle>J Sci Med Sport</addtitle><date>2000-12</date><risdate>2000</risdate><volume>3</volume><issue>4</issue><spage>383</spage><epage>390</epage><pages>383-390</pages><issn>1440-2440</issn><eissn>1878-1861</eissn><abstract>Blood coagulation parameters (thromboplastin time, PT; activated partial thromboplastin time, aPTT; fibrinogen; antithrombin III, ATIII; von Willebrand factor-concentration, vWF; factor VIII-activity, FVIII) and fibrinolytic parameters (plasminogen; (α-antiplasmin; euglobulin-lysis- time, Elt; tissue plasminogenactivator-antigen, tPA-antigen; plasminogenactivator-1-antigen, PAI-1-antigen) were evaluated in 34 women on low-dose oral contraceptives (OC) twice at intervals of 12 weeks each time before and after maximal exercise. During the 12 weeks, 24 women took part in an aerobic conditioning program and 10 women were requested to avoid any kind of sports activity for this period. Blood samples were taken before training and before and after maximal treadmill exercise. This procedure was repeated after the training program. After maximal exercise we found a significant reduction of aPTT and PT (increase in %), a decrease in ATIII, vWF, fibrinogen, plasminogen and α
2-antiplasmin but an increase in fibrinolytic activity (all p<0,05). Maximal exercise is associated with an increase in blood coagulation and fibrinolysis also in women taking OC. After the physical conditioning program an increase in fibrinolytic activity at rest was noted in the training group. Opposed to that the fibrinolytic activity at rest decreased in the control group after abstinence of sports activity over this period (p<0,05, MANOVA).</abstract><cop>Australia</cop><pub>Elsevier Ltd</pub><pmid>11235004</pmid><doi>10.1016/S1440-2440(00)80005-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1440-2440 |
| ispartof | Journal of science and medicine in sport, 2000-12, Vol.3 (4), p.383-390 |
| issn | 1440-2440 1878-1861 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18143079 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Analysis of Variance Blood Coagulation - drug effects Blood Coagulation - physiology Conditioning (Psychology) - physiology Contraceptives, Oral, Combined - administration & dosage Contraceptives, Oral, Hormonal - administration & dosage Desogestrel - administration & dosage Dose-Response Relationship, Drug Ethinyl Estradiol - administration & dosage Exercise Test Female Fibrinolysis - drug effects Fibrinolysis - physiology Humans Levonorgestrel - administration & dosage Physical Education and Training Physical Exertion - physiology Probability Reference Values Thrombophilia - chemically induced Thrombophilia - physiopathology |
| title | Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A22%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20blood%20coagulation%20and%20fibrinolysis%20associated%20with%20maximal%20exercise%20and%20physical%20conditioning%20in%20women%20taking%20low%20dose%20oral%20contraceptives&rft.jtitle=Journal%20of%20science%20and%20medicine%20in%20sport&rft.au=Hilberg,%20Thomas&rft.date=2000-12&rft.volume=3&rft.issue=4&rft.spage=383&rft.epage=390&rft.pages=383-390&rft.issn=1440-2440&rft.eissn=1878-1861&rft_id=info:doi/10.1016/S1440-2440(00)80005-5&rft_dat=%3Cproquest_cross%3E18143079%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18143079&rft_id=info:pmid/11235004&rft_els_id=S1440244000800055&rfr_iscdi=true |