Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration
Liver regeneration in response to various forms of liver injury is a complex process, which ultimately results in restoration of the original liver mass and function. Because the underlying mechanisms that initiate this response are still incompletely defined, this study was aimed to identify novel...
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| Veröffentlicht in: | The Journal of biological chemistry 2001-11, Vol.276 (48), p.44512-44520 |
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| container_issue | 48 |
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| container_title | The Journal of biological chemistry |
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| creator | van der Vliet, H N Sammels, M G Leegwater, A C Levels, J H Reitsma, P H Boers, W Chamuleau, R A |
| description | Liver regeneration in response to various forms of liver injury is a complex process, which ultimately results in restoration of the original liver mass and function. Because the underlying mechanisms that initiate this response are still incompletely defined, this study was aimed to identify novel factors. Liver genes that were up-regulated 6 h after 70% hepatectomy (PHx) in the rat were selected by cDNA subtractive hybridization. Besides known genes associated with cell proliferation, several novel genes were isolated. The novel gene that was most up-regulated was further studied. Its mRNA showed a liver-specific expression and encoded a protein comprising 367 amino acids. The mouse and human cDNA analogues were also isolated and appeared to be highly homologous. The human gene analogue was located at an apolipoprotein gene cluster on chromosome 11q23. The protein encoded by this gene had appreciable homology with apolipoproteins A-I and A-IV. Maximal expression of the gene in the rat liver and its gene product in rat plasma was observed 6 h after PHx. The protein was present in plasma fractions containing high density lipoprotein particles. Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration. |
| doi_str_mv | 10.1074/jbc.M106888200 |
| format | Article |
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Because the underlying mechanisms that initiate this response are still incompletely defined, this study was aimed to identify novel factors. Liver genes that were up-regulated 6 h after 70% hepatectomy (PHx) in the rat were selected by cDNA subtractive hybridization. Besides known genes associated with cell proliferation, several novel genes were isolated. The novel gene that was most up-regulated was further studied. Its mRNA showed a liver-specific expression and encoded a protein comprising 367 amino acids. The mouse and human cDNA analogues were also isolated and appeared to be highly homologous. The human gene analogue was located at an apolipoprotein gene cluster on chromosome 11q23. The protein encoded by this gene had appreciable homology with apolipoproteins A-I and A-IV. Maximal expression of the gene in the rat liver and its gene product in rat plasma was observed 6 h after PHx. The protein was present in plasma fractions containing high density lipoprotein particles. Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration.</description><identifier>ISSN: 0021-9258</identifier><identifier>DOI: 10.1074/jbc.M106888200</identifier><identifier>PMID: 11577099</identifier><language>eng</language><publisher>United States</publisher><subject>Amino Acid Sequence ; Amino Acids - chemistry ; Animals ; Apolipoprotein A-V ; Apolipoproteins ; Apolipoproteins A - biosynthesis ; Apolipoproteins A - blood ; Apolipoproteins A - chemistry ; Apolipoproteins A - genetics ; Apolipoproteins A - metabolism ; Base Sequence ; Blotting, Northern ; Blotting, Western ; Chromatography, Gel ; chromosome 11 ; Chromosomes, Human, Pair 11 ; DNA, Complementary - metabolism ; Humans ; Liver - physiology ; Male ; Mice ; Models, Genetic ; Molecular Sequence Data ; Nucleic Acid Hybridization ; Rats ; Rats, Wistar ; Regeneration ; RNA, Messenger - metabolism ; Sequence Homology, Amino Acid ; Time Factors ; Tissue Distribution ; Up-Regulation</subject><ispartof>The Journal of biological chemistry, 2001-11, Vol.276 (48), p.44512-44520</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11577099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Vliet, H N</creatorcontrib><creatorcontrib>Sammels, M G</creatorcontrib><creatorcontrib>Leegwater, A C</creatorcontrib><creatorcontrib>Levels, J H</creatorcontrib><creatorcontrib>Reitsma, P H</creatorcontrib><creatorcontrib>Boers, W</creatorcontrib><creatorcontrib>Chamuleau, R A</creatorcontrib><title>Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Liver regeneration in response to various forms of liver injury is a complex process, which ultimately results in restoration of the original liver mass and function. Because the underlying mechanisms that initiate this response are still incompletely defined, this study was aimed to identify novel factors. Liver genes that were up-regulated 6 h after 70% hepatectomy (PHx) in the rat were selected by cDNA subtractive hybridization. Besides known genes associated with cell proliferation, several novel genes were isolated. The novel gene that was most up-regulated was further studied. Its mRNA showed a liver-specific expression and encoded a protein comprising 367 amino acids. The mouse and human cDNA analogues were also isolated and appeared to be highly homologous. The human gene analogue was located at an apolipoprotein gene cluster on chromosome 11q23. The protein encoded by this gene had appreciable homology with apolipoproteins A-I and A-IV. Maximal expression of the gene in the rat liver and its gene product in rat plasma was observed 6 h after PHx. The protein was present in plasma fractions containing high density lipoprotein particles. Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration.</description><subject>Amino Acid Sequence</subject><subject>Amino Acids - chemistry</subject><subject>Animals</subject><subject>Apolipoprotein A-V</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins A - biosynthesis</subject><subject>Apolipoproteins A - blood</subject><subject>Apolipoproteins A - chemistry</subject><subject>Apolipoproteins A - genetics</subject><subject>Apolipoproteins A - metabolism</subject><subject>Base Sequence</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>Chromatography, Gel</subject><subject>chromosome 11</subject><subject>Chromosomes, Human, Pair 11</subject><subject>DNA, Complementary - metabolism</subject><subject>Humans</subject><subject>Liver - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Models, Genetic</subject><subject>Molecular Sequence Data</subject><subject>Nucleic Acid Hybridization</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regeneration</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Up-Regulation</subject><issn>0021-9258</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1PwzAYhD2AaCmsjMgTW4o_ktphqyq-pCIWYI1e22-oKzcOdlrUf08lysAtN9yj0-kIueJsypkqb9fGTl84m2mtBWMnZMyY4EUtKj0i5zmv2UFlzc_IiPNKKVbXY9LM-xh8H_sUB_QdnRcfdxRoF3cYKPzPIOdoPQzo6LcfVhQ6ipDCnvYryEhjS4PfYaIJP7HDBIOP3QU5bSFkvDz6hLw_3L8tnorl6-PzYr4seiH1UAg0tlVSo2mlFTgrhROotHZWVNYoayrpnLEAylluGcpKCq6ZKK1DKUUrJ-Tmt_cw9muLeWg2PlsMATqM29xwzaVSfHYAr4_g1mzQNX3yG0j75u8S-QMleGOS</recordid><startdate>20011130</startdate><enddate>20011130</enddate><creator>van der Vliet, H N</creator><creator>Sammels, M G</creator><creator>Leegwater, A C</creator><creator>Levels, J H</creator><creator>Reitsma, P H</creator><creator>Boers, W</creator><creator>Chamuleau, R A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20011130</creationdate><title>Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration</title><author>van der Vliet, H N ; Sammels, M G ; Leegwater, A C ; Levels, J H ; Reitsma, P H ; Boers, W ; Chamuleau, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p238t-2ebcf738ebf3c2e642d2e788dc25cb7cb53ddbcaa7dc1c0e353218024cde332f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Amino Acids - chemistry</topic><topic>Animals</topic><topic>Apolipoprotein A-V</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins A - biosynthesis</topic><topic>Apolipoproteins A - blood</topic><topic>Apolipoproteins A - chemistry</topic><topic>Apolipoproteins A - genetics</topic><topic>Apolipoproteins A - metabolism</topic><topic>Base Sequence</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>Chromatography, Gel</topic><topic>chromosome 11</topic><topic>Chromosomes, Human, Pair 11</topic><topic>DNA, Complementary - metabolism</topic><topic>Humans</topic><topic>Liver - physiology</topic><topic>Male</topic><topic>Mice</topic><topic>Models, Genetic</topic><topic>Molecular Sequence Data</topic><topic>Nucleic Acid Hybridization</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regeneration</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Homology, Amino Acid</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Vliet, H N</creatorcontrib><creatorcontrib>Sammels, M G</creatorcontrib><creatorcontrib>Leegwater, A C</creatorcontrib><creatorcontrib>Levels, J H</creatorcontrib><creatorcontrib>Reitsma, P H</creatorcontrib><creatorcontrib>Boers, W</creatorcontrib><creatorcontrib>Chamuleau, R A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Vliet, H N</au><au>Sammels, M G</au><au>Leegwater, A C</au><au>Levels, J H</au><au>Reitsma, P H</au><au>Boers, W</au><au>Chamuleau, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>2001-11-30</date><risdate>2001</risdate><volume>276</volume><issue>48</issue><spage>44512</spage><epage>44520</epage><pages>44512-44520</pages><issn>0021-9258</issn><abstract>Liver regeneration in response to various forms of liver injury is a complex process, which ultimately results in restoration of the original liver mass and function. Because the underlying mechanisms that initiate this response are still incompletely defined, this study was aimed to identify novel factors. Liver genes that were up-regulated 6 h after 70% hepatectomy (PHx) in the rat were selected by cDNA subtractive hybridization. Besides known genes associated with cell proliferation, several novel genes were isolated. The novel gene that was most up-regulated was further studied. Its mRNA showed a liver-specific expression and encoded a protein comprising 367 amino acids. The mouse and human cDNA analogues were also isolated and appeared to be highly homologous. The human gene analogue was located at an apolipoprotein gene cluster on chromosome 11q23. The protein encoded by this gene had appreciable homology with apolipoproteins A-I and A-IV. Maximal expression of the gene in the rat liver and its gene product in rat plasma was observed 6 h after PHx. The protein was present in plasma fractions containing high density lipoprotein particles. Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration.</abstract><cop>United States</cop><pmid>11577099</pmid><doi>10.1074/jbc.M106888200</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Amino Acids - chemistry Animals Apolipoprotein A-V Apolipoproteins Apolipoproteins A - biosynthesis Apolipoproteins A - blood Apolipoproteins A - chemistry Apolipoproteins A - genetics Apolipoproteins A - metabolism Base Sequence Blotting, Northern Blotting, Western Chromatography, Gel chromosome 11 Chromosomes, Human, Pair 11 DNA, Complementary - metabolism Humans Liver - physiology Male Mice Models, Genetic Molecular Sequence Data Nucleic Acid Hybridization Rats Rats, Wistar Regeneration RNA, Messenger - metabolism Sequence Homology, Amino Acid Time Factors Tissue Distribution Up-Regulation |
| title | Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration |
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