In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

Epilepsy is a common neurological disorder caused by an imbalance between inhibitory and excitatory neurotransmission. It is well known that neuronal excitability is related to γ‐aminobutyric acid (GABA)ergic depolarization. HCO3−‐dependent depolarization can be suppressed by membrane‐permeable inhi...

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Veröffentlicht in:	ChemMedChem 2016-08, Vol.11 (16), p.1812-1818
Hauptverfasser:	Bruno, Elvira, Buemi, Maria R., De Luca, Laura, Ferro, Stefania, Monforte, Anna-Maria, Supuran, Claudiu T., Vullo, Daniela, De Sarro, Giovambattista, Russo, Emilio, Gitto, Rosaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticonvulsants Anticonvulsants - chemical synthesis Anticonvulsants - chemistry Anticonvulsants - pharmacology Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology carbonic anhydrases Carbonic Anhydrases - metabolism Dose-Response Relationship, Drug Humans inhibitors isoquinoline sulfonamides Mice Mice, Inbred DBA Molecular Structure Seizures - drug therapy Structure-Activity Relationship sulfur
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