Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms
Abstract Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisoc...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2016-08, Vol.254, p.180-187 |
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| creator | Cohn, Moran D Viding, Essi McCrory, Eamon Pape, Louise van den Brink, Wim Doreleijers, Theo A.H Veltman, Dick J Popma, Arne |
| description | Abstract Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7y), characterised by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations. |
| doi_str_mv | 10.1016/j.pscychresns.2016.07.003 |
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However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7y), characterised by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2016.07.003</identifier><identifier>PMID: 27479922</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Amygdala - diagnostic imaging ; Amygdala - pathology ; Antisocial personality disorder ; Antisocial Personality Disorder - diagnostic imaging ; Antisocial Personality Disorder - pathology ; Antisocial Personality Disorder - psychology ; Brain - diagnostic imaging ; Brain - pathology ; Brain structure ; Callous-unemotional traits ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Child ; Conduct disorder ; Conduct Disorder - diagnostic imaging ; Conduct Disorder - pathology ; Conduct Disorder - psychology ; Emotions ; Female ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Humans ; Limited prosocial emotions ; Magnetic Resonance Imaging - methods ; Male ; Organ Size ; Psychiatry ; Psychopathy ; Radiology ; Voxel-based morphometry ; Young Adult</subject><ispartof>Psychiatry research. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-58159d9ad4666aeabb15769308714ee5e039da1cd5ddb855cc6170af8800630b3</citedby><cites>FETCH-LOGICAL-c483t-58159d9ad4666aeabb15769308714ee5e039da1cd5ddb855cc6170af8800630b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2016.07.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27479922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohn, Moran D</creatorcontrib><creatorcontrib>Viding, Essi</creatorcontrib><creatorcontrib>McCrory, Eamon</creatorcontrib><creatorcontrib>Pape, Louise</creatorcontrib><creatorcontrib>van den Brink, Wim</creatorcontrib><creatorcontrib>Doreleijers, Theo A.H</creatorcontrib><creatorcontrib>Veltman, Dick J</creatorcontrib><creatorcontrib>Popma, Arne</creatorcontrib><title>Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res Neuroimaging</addtitle><description>Abstract Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7y), characterised by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.</description><subject>Adolescent</subject><subject>Amygdala - diagnostic imaging</subject><subject>Amygdala - pathology</subject><subject>Antisocial personality disorder</subject><subject>Antisocial Personality Disorder - diagnostic imaging</subject><subject>Antisocial Personality Disorder - pathology</subject><subject>Antisocial Personality Disorder - psychology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain structure</subject><subject>Callous-unemotional traits</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Child</subject><subject>Conduct disorder</subject><subject>Conduct Disorder - diagnostic imaging</subject><subject>Conduct Disorder - pathology</subject><subject>Conduct Disorder - psychology</subject><subject>Emotions</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Limited prosocial emotions</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Organ Size</subject><subject>Psychiatry</subject><subject>Psychopathy</subject><subject>Radiology</subject><subject>Voxel-based morphometry</subject><subject>Young Adult</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxiMEotvCKyBz45LFf5LY4YCEVlCQKiEBPVuOPbv1NrEXj1OUZ-Fl8bItQpw4WbK_mc_f_KaqXjK6ZpR1r_frA9rF3iTAgGtertZUrikVj6oVU5LXsqXd42pFe97WTc_lWXWOuKeUC9WJp9UZl43se85X1c8vsPMxmJHsEixkMjlDIndxnCcgJjhiY7AQcjK5yIgPxOQ6ebwlxsUR8PiGb8h1yCbsRh92xCBG63_Lkfzw-YZYM45xxnoOMMV8cisNfcYHBzfbTJzHmFxxx2U65Djhs-rJ1owIz-_Pi-r6w_tvm4_11efLT5t3V7VtlMh1q1jbu964pus6A2YYWCu7XlAlWQPQAhW9M8y61rlBta21HZPUbJWitBN0EBfVq1PfQ4rfZ8CsJ1-CjaMJUP6tmWKi47xVokj7k9SmiJhgqw_JTyYtmlF9ZKP3-i82-shGU6kLm1L74t5mHiZwfyofYBTB5iSAEvbOQ9JoPZTxO5_AZu2i_y-bt_90sYWLLxBuYQHcxzkVACWVRq6p_npckuOOsDILJqQSvwA7AcBh</recordid><startdate>20160830</startdate><enddate>20160830</enddate><creator>Cohn, Moran D</creator><creator>Viding, Essi</creator><creator>McCrory, Eamon</creator><creator>Pape, Louise</creator><creator>van den Brink, Wim</creator><creator>Doreleijers, Theo A.H</creator><creator>Veltman, Dick J</creator><creator>Popma, Arne</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160830</creationdate><title>Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms</title><author>Cohn, Moran D ; Viding, Essi ; McCrory, Eamon ; Pape, Louise ; van den Brink, Wim ; Doreleijers, Theo A.H ; Veltman, Dick J ; Popma, Arne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-58159d9ad4666aeabb15769308714ee5e039da1cd5ddb855cc6170af8800630b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Amygdala - diagnostic imaging</topic><topic>Amygdala - pathology</topic><topic>Antisocial personality disorder</topic><topic>Antisocial Personality Disorder - diagnostic imaging</topic><topic>Antisocial Personality Disorder - pathology</topic><topic>Antisocial Personality Disorder - psychology</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain structure</topic><topic>Callous-unemotional traits</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Child</topic><topic>Conduct disorder</topic><topic>Conduct Disorder - diagnostic imaging</topic><topic>Conduct Disorder - pathology</topic><topic>Conduct Disorder - psychology</topic><topic>Emotions</topic><topic>Female</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Limited prosocial emotions</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Organ Size</topic><topic>Psychiatry</topic><topic>Psychopathy</topic><topic>Radiology</topic><topic>Voxel-based morphometry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohn, Moran D</creatorcontrib><creatorcontrib>Viding, Essi</creatorcontrib><creatorcontrib>McCrory, Eamon</creatorcontrib><creatorcontrib>Pape, Louise</creatorcontrib><creatorcontrib>van den Brink, Wim</creatorcontrib><creatorcontrib>Doreleijers, Theo A.H</creatorcontrib><creatorcontrib>Veltman, Dick J</creatorcontrib><creatorcontrib>Popma, Arne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohn, Moran D</au><au>Viding, Essi</au><au>McCrory, Eamon</au><au>Pape, Louise</au><au>van den Brink, Wim</au><au>Doreleijers, Theo A.H</au><au>Veltman, Dick J</au><au>Popma, Arne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res Neuroimaging</addtitle><date>2016-08-30</date><risdate>2016</risdate><volume>254</volume><spage>180</spage><epage>187</epage><pages>180-187</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7y), characterised by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>27479922</pmid><doi>10.1016/j.pscychresns.2016.07.003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Amygdala - diagnostic imaging Amygdala - pathology Antisocial personality disorder Antisocial Personality Disorder - diagnostic imaging Antisocial Personality Disorder - pathology Antisocial Personality Disorder - psychology Brain - diagnostic imaging Brain - pathology Brain structure Callous-unemotional traits Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Child Conduct disorder Conduct Disorder - diagnostic imaging Conduct Disorder - pathology Conduct Disorder - psychology Emotions Female Gray Matter - diagnostic imaging Gray Matter - pathology Humans Limited prosocial emotions Magnetic Resonance Imaging - methods Male Organ Size Psychiatry Psychopathy Radiology Voxel-based morphometry Young Adult |
| title | Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms |
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