Genetics of larval urea and ammonia tolerance and cross-tolerance in Drosophila melanogaster
Five laboratory populations of Drosophila melanogaster previously selected for over 60 generations for larval resistance to ammonium chloride (NH 4 Cl), and five populations selected for over 60 generations for larval resistance to urea, were investigated to determine the genetic mechanisms through...
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| Veröffentlicht in: | Heredity 2001-06, Vol.86 (6), p.658-667 |
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| creator | Borash, Daniel J Shimada, Masakazu |
| description | Five laboratory populations of
Drosophila melanogaster
previously selected for over 60 generations for larval resistance to ammonium chloride (NH
4
Cl), and five populations selected for over 60 generations for larval resistance to urea, were investigated to determine the genetic mechanisms through which such tolerance had evolved. To examine the genetics of tolerance to urea and ammonia, egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for each selection regime relative to the control lines, and among reciprocal crosses between each selection regime and the control lines. To examine tolerance to novel nitrogenous compounds (cross-tolerance), egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for reciprocal crosses between the selection lines. Dominance is a major genetic factor in egg-to-adult survivorship in the presence of either urea or ammonia, while cross-tolerance to novel nitrogenous compounds also shows dominance as a major genetic mechanism controlling egg-to-adult survivorship. Dominance and X-linkage appear to be factors affecting developmental time in the presence of either urea or ammonia, although we could not exclude cytoplasmic inheritance as influencing our results. Cross-tolerance to novel nitrogenous compounds shows dominance and X-linkage as the main genetic factors controlling developmental time. We develop a simple hypothesis, in accordance with the results, that there may be two X-linked loci: one controlling urea tolerance and one controlling ammonia tolerance, and one autosomal locus exerting a pleiotropic control of tolerance. However, many other possibilities exist. |
| doi_str_mv | 10.1046/j.1365-2540.2001.00858.x |
| format | Article |
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Drosophila melanogaster
previously selected for over 60 generations for larval resistance to ammonium chloride (NH
4
Cl), and five populations selected for over 60 generations for larval resistance to urea, were investigated to determine the genetic mechanisms through which such tolerance had evolved. To examine the genetics of tolerance to urea and ammonia, egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for each selection regime relative to the control lines, and among reciprocal crosses between each selection regime and the control lines. To examine tolerance to novel nitrogenous compounds (cross-tolerance), egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for reciprocal crosses between the selection lines. Dominance is a major genetic factor in egg-to-adult survivorship in the presence of either urea or ammonia, while cross-tolerance to novel nitrogenous compounds also shows dominance as a major genetic mechanism controlling egg-to-adult survivorship. Dominance and X-linkage appear to be factors affecting developmental time in the presence of either urea or ammonia, although we could not exclude cytoplasmic inheritance as influencing our results. Cross-tolerance to novel nitrogenous compounds shows dominance and X-linkage as the main genetic factors controlling developmental time. We develop a simple hypothesis, in accordance with the results, that there may be two X-linked loci: one controlling urea tolerance and one controlling ammonia tolerance, and one autosomal locus exerting a pleiotropic control of tolerance. However, many other possibilities exist.</description><identifier>ISSN: 0018-067X</identifier><identifier>EISSN: 1365-2540</identifier><identifier>DOI: 10.1046/j.1365-2540.2001.00858.x</identifier><identifier>PMID: 11595046</identifier><identifier>CODEN: HDTYAT</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Ammonia ; Ammonium ; Ammonium Chloride - pharmacology ; Ammonium Chloride - toxicity ; Animals ; Biomedical and Life Sciences ; Biomedicine ; cross-tolerance ; Crosses, Genetic ; Cytogenetics ; Drosophila melanogaster ; Drosophila melanogaster - drug effects ; Drosophila melanogaster - genetics ; Drug Tolerance - genetics ; Ecology ; Evolutionary Biology ; Female ; Genes, Dominant - genetics ; Genetic factors ; Genetic Linkage - genetics ; Genetics ; Human Genetics ; Hybridization, Genetic - genetics ; Larva - drug effects ; Larva - genetics ; Male ; Models, Genetic ; original-article ; Ovum - drug effects ; Plant Genetics and Genomics ; Survival Rate ; Time Factors ; Urea ; Urea - pharmacology ; Urea - toxicity ; X Chromosome - genetics</subject><ispartof>Heredity, 2001-06, Vol.86 (6), p.658-667</ispartof><rights>The Genetical Society of Great Britain 2001</rights><rights>Copyright Blackwell Science Ltd. Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-f584331d46f02d4e8cc0440a7da1097efc02b7c1011703415ddddc384126ab383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1046/j.1365-2540.2001.00858.x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1046/j.1365-2540.2001.00858.x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11595046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borash, Daniel J</creatorcontrib><creatorcontrib>Shimada, Masakazu</creatorcontrib><title>Genetics of larval urea and ammonia tolerance and cross-tolerance in Drosophila melanogaster</title><title>Heredity</title><addtitle>Heredity</addtitle><addtitle>Heredity (Edinb)</addtitle><description>Five laboratory populations of
Drosophila melanogaster
previously selected for over 60 generations for larval resistance to ammonium chloride (NH
4
Cl), and five populations selected for over 60 generations for larval resistance to urea, were investigated to determine the genetic mechanisms through which such tolerance had evolved. To examine the genetics of tolerance to urea and ammonia, egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for each selection regime relative to the control lines, and among reciprocal crosses between each selection regime and the control lines. To examine tolerance to novel nitrogenous compounds (cross-tolerance), egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for reciprocal crosses between the selection lines. Dominance is a major genetic factor in egg-to-adult survivorship in the presence of either urea or ammonia, while cross-tolerance to novel nitrogenous compounds also shows dominance as a major genetic mechanism controlling egg-to-adult survivorship. Dominance and X-linkage appear to be factors affecting developmental time in the presence of either urea or ammonia, although we could not exclude cytoplasmic inheritance as influencing our results. Cross-tolerance to novel nitrogenous compounds shows dominance and X-linkage as the main genetic factors controlling developmental time. We develop a simple hypothesis, in accordance with the results, that there may be two X-linked loci: one controlling urea tolerance and one controlling ammonia tolerance, and one autosomal locus exerting a pleiotropic control of tolerance. However, many other possibilities exist.</description><subject>Ammonia</subject><subject>Ammonium</subject><subject>Ammonium Chloride - pharmacology</subject><subject>Ammonium Chloride - toxicity</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>cross-tolerance</subject><subject>Crosses, Genetic</subject><subject>Cytogenetics</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - drug effects</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drug Tolerance - genetics</subject><subject>Ecology</subject><subject>Evolutionary Biology</subject><subject>Female</subject><subject>Genes, Dominant - genetics</subject><subject>Genetic factors</subject><subject>Genetic Linkage - genetics</subject><subject>Genetics</subject><subject>Human Genetics</subject><subject>Hybridization, Genetic - genetics</subject><subject>Larva - drug effects</subject><subject>Larva - genetics</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>original-article</subject><subject>Ovum - drug effects</subject><subject>Plant Genetics and Genomics</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Urea</subject><subject>Urea - pharmacology</subject><subject>Urea - toxicity</subject><subject>X Chromosome - genetics</subject><issn>0018-067X</issn><issn>1365-2540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkEtLxDAUhYMoOj7-ggQX7lrvbZI2XYpvENwouBBCJk21Q9uMSSvjvzfzwAE3ZhO459zDuR8hFCFF4PnFLEWWiyQTHNIMAFMAKWS62CGTX2GXTKIiE8iL1wNyGMIMAFiRlfvkAFGUIgZNyNud7e3QmEBdTVvtv3RLR2811X1Fdde5vtF0cK31ujd2NTXehZBsZ01Pr-PIzT-aVtPOtrp37zoM1h-TvVq3wZ5s_iPycnvzfHWfPD7dPVxdPiaG5-WQ1EJyxrDieQ1Zxa00BjgHXVQaoSxsbSCbFgYBsQDGUVTxGSY5ZrmeMsmOyPk6d-7d52jDoLomGNvGJtaNQaFEJkqG0Xj2xzhzo-9jN5WxSCtjhYgmuTatDvW2VnPfdNp_KwS1xK9maklZLSmrJX61wq8WcfV0kz9OO1ttFze8o6FcG0KU-nfrtwX-Df8Bw2GSwA</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Borash, Daniel J</creator><creator>Shimada, Masakazu</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20010601</creationdate><title>Genetics of larval urea and ammonia tolerance and cross-tolerance in Drosophila melanogaster</title><author>Borash, Daniel J ; Shimada, Masakazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-f584331d46f02d4e8cc0440a7da1097efc02b7c1011703415ddddc384126ab383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Ammonia</topic><topic>Ammonium</topic><topic>Ammonium Chloride - pharmacology</topic><topic>Ammonium Chloride - toxicity</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>cross-tolerance</topic><topic>Crosses, Genetic</topic><topic>Cytogenetics</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - drug effects</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drug Tolerance - genetics</topic><topic>Ecology</topic><topic>Evolutionary Biology</topic><topic>Female</topic><topic>Genes, Dominant - genetics</topic><topic>Genetic factors</topic><topic>Genetic Linkage - genetics</topic><topic>Genetics</topic><topic>Human Genetics</topic><topic>Hybridization, Genetic - genetics</topic><topic>Larva - drug effects</topic><topic>Larva - genetics</topic><topic>Male</topic><topic>Models, Genetic</topic><topic>original-article</topic><topic>Ovum - drug effects</topic><topic>Plant Genetics and Genomics</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Urea</topic><topic>Urea - pharmacology</topic><topic>Urea - toxicity</topic><topic>X Chromosome - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borash, Daniel J</creatorcontrib><creatorcontrib>Shimada, Masakazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borash, Daniel J</au><au>Shimada, Masakazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetics of larval urea and ammonia tolerance and cross-tolerance in Drosophila melanogaster</atitle><jtitle>Heredity</jtitle><stitle>Heredity</stitle><addtitle>Heredity (Edinb)</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>86</volume><issue>6</issue><spage>658</spage><epage>667</epage><pages>658-667</pages><issn>0018-067X</issn><eissn>1365-2540</eissn><coden>HDTYAT</coden><abstract>Five laboratory populations of
Drosophila melanogaster
previously selected for over 60 generations for larval resistance to ammonium chloride (NH
4
Cl), and five populations selected for over 60 generations for larval resistance to urea, were investigated to determine the genetic mechanisms through which such tolerance had evolved. To examine the genetics of tolerance to urea and ammonia, egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for each selection regime relative to the control lines, and among reciprocal crosses between each selection regime and the control lines. To examine tolerance to novel nitrogenous compounds (cross-tolerance), egg-to-adult survivorship and developmental time were measured at two different NH
4
Cl levels and two different urea levels for reciprocal crosses between the selection lines. Dominance is a major genetic factor in egg-to-adult survivorship in the presence of either urea or ammonia, while cross-tolerance to novel nitrogenous compounds also shows dominance as a major genetic mechanism controlling egg-to-adult survivorship. Dominance and X-linkage appear to be factors affecting developmental time in the presence of either urea or ammonia, although we could not exclude cytoplasmic inheritance as influencing our results. Cross-tolerance to novel nitrogenous compounds shows dominance and X-linkage as the main genetic factors controlling developmental time. We develop a simple hypothesis, in accordance with the results, that there may be two X-linked loci: one controlling urea tolerance and one controlling ammonia tolerance, and one autosomal locus exerting a pleiotropic control of tolerance. However, many other possibilities exist.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>11595046</pmid><doi>10.1046/j.1365-2540.2001.00858.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ammonia Ammonium Ammonium Chloride - pharmacology Ammonium Chloride - toxicity Animals Biomedical and Life Sciences Biomedicine cross-tolerance Crosses, Genetic Cytogenetics Drosophila melanogaster Drosophila melanogaster - drug effects Drosophila melanogaster - genetics Drug Tolerance - genetics Ecology Evolutionary Biology Female Genes, Dominant - genetics Genetic factors Genetic Linkage - genetics Genetics Human Genetics Hybridization, Genetic - genetics Larva - drug effects Larva - genetics Male Models, Genetic original-article Ovum - drug effects Plant Genetics and Genomics Survival Rate Time Factors Urea Urea - pharmacology Urea - toxicity X Chromosome - genetics |
| title | Genetics of larval urea and ammonia tolerance and cross-tolerance in Drosophila melanogaster |
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