Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five skin carcinogens

In a previous paper, we presented a practical in vivo micronucleus (MN) test that used rat skin as the target organ. To evaluate the test, as well as to determine the reproducibility and applicability of the method to mice, we used it to test the effect of five skin carcinogens ( N-ethyl- N′-nitro-...

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Veröffentlicht in:	Mutation research 2002-01, Vol.513 (1), p.93-102
Hauptverfasser:	Nishikawa, Takashi, Haresaku, Mitsuru, Fukushima, Akira, Nakamura, Tsuneaki, Adachi, Kuniaki, Masuda, Mitsuteru, Hayashi, Makoto
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Sprache:	eng
Schlagworte:	4-Nitroquinoline 1-oxide 4-Nitroquinoline-1-oxide - toxicity 7,12-Dimethylbenz[a]anthracene 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Benzo(a)pyrene - toxicity Benzo[a]pyrene Biological and medical sciences Carcinogens - toxicity Chemical mutagenesis Fundamental and applied biological sciences. Psychology Male Medical sciences Methylnitronitrosoguanidine - analogs & derivatives Methylnitronitrosoguanidine - toxicity Mice Mice, Inbred ICR micronuclei Micronucleus Tests Molecular and cellular biology N-ethyl- N′-nitro- N-nitrosoguanidine N-methyl- N′-nitro- N-nitrosoguanidine Rats Rats, Sprague-Dawley Skin - drug effects Skin micronucleus test Toxicology
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creator	Nishikawa, Takashi Haresaku, Mitsuru Fukushima, Akira Nakamura, Tsuneaki Adachi, Kuniaki Masuda, Mitsuteru Hayashi, Makoto
description	In a previous paper, we presented a practical in vivo micronucleus (MN) test that used rat skin as the target organ. To evaluate the test, as well as to determine the reproducibility and applicability of the method to mice, we used it to test the effect of five skin carcinogens ( N-ethyl- N′-nitro- N-nitrosoguanidine (ENNG), N-methyl- N′-nitro- N-nitrosoguanidine (MNNG), 4-nitroquinoline 1-oxide (4NQO), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (B[a]P)) on rat and mouse skin. All five compounds significantly and dose-dependently increased the MN frequencies in the basal cells of the chemical-treated skin. These results indicated the reproducibility of the test results and also the applicability of the test to mice as well as rats.
doi_str_mv	10.1016/S1383-5718(01)00292-3
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To evaluate the test, as well as to determine the reproducibility and applicability of the method to mice, we used it to test the effect of five skin carcinogens ( N-ethyl- N′-nitro- N-nitrosoguanidine (ENNG), N-methyl- N′-nitro- N-nitrosoguanidine (MNNG), 4-nitroquinoline 1-oxide (4NQO), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (B[a]P)) on rat and mouse skin. All five compounds significantly and dose-dependently increased the MN frequencies in the basal cells of the chemical-treated skin. 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subjects	4-Nitroquinoline 1-oxide 4-Nitroquinoline-1-oxide - toxicity 7,12-Dimethylbenz[a]anthracene 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Benzo(a)pyrene - toxicity Benzo[a]pyrene Biological and medical sciences Carcinogens - toxicity Chemical mutagenesis Fundamental and applied biological sciences. Psychology Male Medical sciences Methylnitronitrosoguanidine - analogs & derivatives Methylnitronitrosoguanidine - toxicity Mice Mice, Inbred ICR micronuclei Micronucleus Tests Molecular and cellular biology N-ethyl- N′-nitro- N-nitrosoguanidine N-methyl- N′-nitro- N-nitrosoguanidine Rats Rats, Sprague-Dawley Skin - drug effects Skin micronucleus test Toxicology
title	Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five skin carcinogens
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