IL-12 Prevents the Inhibitory Effects of cis-Urocanic Acid on Tumor Antigen Presentation by Langerhans Cells: Implications for Photocarcinogenesis

UV radiation induces skin cancer primarily by its DNA-damaging properties, but also by its capacity to suppress the immune system. The photoisomer of urocanic acid (UCA), cis-UCA, is an important mediator of UV-induced immunosuppression and is involved in the inhibition of tumor immunity. The immuno...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2001-12, Vol.167 (11), p.6232-6238
Hauptverfasser:	Beissert, Stefan, Ruhlemann, David, Mohammad, Taj, Grabbe, Stephan, El-Ghorr, Ali, Norval, Mary, Morrison, Harry, Granstein, Richard D, Schwarz, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - drug effects Antigen Presentation - immunology Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Dermatitis, Contact - immunology Dermatitis, Contact - prevention & control Epitopes, T-Lymphocyte - immunology Female Immune Sera - administration & dosage Immunization, Passive Immunosuppressive Agents - antagonists & inhibitors Immunosuppressive Agents - pharmacology Injections, Intraperitoneal Interleukin-12 - physiology Langerhans Cells - drug effects Langerhans Cells - immunology Langerhans Cells - metabolism Lymphocyte Activation - drug effects Mice Mice, Inbred A Mice, Inbred BALB C Mice, Transgenic Neoplasms, Radiation-Induced - immunology photocarcinogenesis skin cancer Skin Neoplasms - immunology Skin Neoplasms - prevention & control T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor Cells, Cultured Ultraviolet Rays urocanic acid Urocanic Acid - administration & dosage Urocanic Acid - antagonists & inhibitors Urocanic Acid - immunology Urocanic Acid - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!