β-Arrestin1 Modulates Lymphoid Enhancer Factor Transcriptional Activity through Interaction with Phosphorylated Dishevelled Proteins

One aspect of the function of the β-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled receptors (GPCRs) to signal transduction pathways distinct from traditional second messenger pathways. Here we report the identification of Dishevelled 1 and Dishevelled 2 (Dvl1 and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-12, Vol.98 (26), p.14889-14894
Hauptverfasser:	Chen, Wei, Hu, Liaoyuan A., Semenov, Mikhail V., Yanagawa, Shinichi, Kikuchi, Akira, Lefkowitz, Robert J., Miller, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Adaptor Proteins, Signal Transducing Animals Antibodies Arrestins - metabolism Arrestins - physiology b-arrestin beta-Arrestins Biological Sciences Cell extracts Cell Line Dishevelled 1 protein Dishevelled 2 protein Dishevelled Proteins DNA-Binding Proteins - genetics Dv1 protein Dv2 protein GSK-3^b protein Humans LEF protein lymphoid enhancer factor Lymphoid Enhancer-Binding Factor 1 Mice PAR-1 protein Phosphatases Phosphoproteins Phosphorylation Plasmids Protein Binding Proteins Proteins - metabolism Receptors Transcription Factors - genetics Transcription, Genetic - physiology Transfection Yeasts
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