Eight-Hour Continuous Normothermic Ex Vivo Kidney Perfusion Is a Safe Preservation Technique for Kidney Transplantation: A New Opportunity for the Storage, Assessment, and Repair of Kidney Grafts

BACKGROUNDHypothermic kidney storage causes preservation injury and is poorly tolerated by renal grafts. We investigated whether static cold storage (SCS) can be safely replaced with a novel technique of pressure-controlled normothermic ex vivo kidney perfusion (NEVKP) in heart-beating donor kidney...

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Veröffentlicht in:	Transplantation 2016-09, Vol.100 (9), p.1862-1870
Hauptverfasser:	Kaths, J Moritz, Echeverri, Juan, Goldaracena, Nicolas, Louis, Kristine S, Chun, Yi-Min, Linares, Ivan, Wiebe, Aryn, Foltys, Daniel B, Yip, Paul M, John, Rohan, Mucsi, Istvan, Ghanekar, Anand, Bagli, Darius J, Grant, David R, Robinson, Lisa A, Selzner, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartate Aminotransferases - metabolism Biomarkers - metabolism Blood Urea Nitrogen Cold Ischemia - adverse effects Creatinine - blood Feasibility Studies Glucose - pharmacology Graft Survival Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - surgery Kidney Transplantation - adverse effects Kidney Transplantation - methods L-Lactate Dehydrogenase - metabolism Lactic Acid - metabolism Male Mannitol - pharmacology Models, Animal Nephrectomy Organ Preservation - adverse effects Organ Preservation - methods Organ Preservation Solutions - pharmacology Perfusion - adverse effects Potassium Chloride - pharmacology Pressure Procaine - pharmacology Sus scrofa Time Factors Tissue Survival Transplantation, Autologous
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