Synthesis of Substituted Oxazoles by Visible-Light Photocatalysis
A simple and practical method for the synthesis of substituted oxazoles has been developed using readily available α-bromoketones and benzylamines by visible-light photocatalysis at room temperature. The process, which requires 1 mol % of [Ru(bpy)3]Cl2 photocatalyst with K3PO4 and CCl3Br, is effec...
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| Veröffentlicht in: | Journal of organic chemistry 2016-08, Vol.81 (16), p.6995-7000 |
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| container_title | Journal of organic chemistry |
| container_volume | 81 |
| creator | Chatterjee, Tanmay Cho, Ji Young Cho, Eun Jin |
| description | A simple and practical method for the synthesis of substituted oxazoles has been developed using readily available α-bromoketones and benzylamines by visible-light photocatalysis at room temperature. The process, which requires 1 mol % of [Ru(bpy)3]Cl2 photocatalyst with K3PO4 and CCl3Br, is effective for accessing a variety of valuable oxazole compounds. The synthetic utility of our protocol was also demonstrated by preparing a natural product, texaline. |
| doi_str_mv | 10.1021/acs.joc.6b00989 |
| format | Article |
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The process, which requires 1 mol % of [Ru(bpy)3]Cl2 photocatalyst with K3PO4 and CCl3Br, is effective for accessing a variety of valuable oxazole compounds. 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| title | Synthesis of Substituted Oxazoles by Visible-Light Photocatalysis |
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