Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit
To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors. The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-...
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| Veröffentlicht in: | Journal of the Pakistan Medical Association 2016-08, Vol.66 (8), p.961-967 |
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| container_title | Journal of the Pakistan Medical Association |
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| creator | Siddiqui, Emad Uddin Kazi, Sayyeda Ghazala Habib, Muhammad Irfan Ahmed Khan, Khalid Mehmood Zia, Nukhba |
| description | To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors.
The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis.
Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm.
Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day. |
| format | Article |
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The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis.
Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm.
Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 27524528</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bone Marrow Neoplasms - epidemiology ; Central Nervous System Neoplasms - epidemiology ; Chemotherapy ; Child ; Child, Preschool ; Diagnosis ; Female ; Humans ; Leukocyte Count ; Male ; Neoplasm Recurrence, Local - epidemiology ; Pakistan - epidemiology ; Pediatrics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Prognosis ; Prospective Studies ; Recurrence (Disease) ; Sex Factors ; Tertiary Care Centers</subject><ispartof>Journal of the Pakistan Medical Association, 2016-08, Vol.66 (8), p.961-967</ispartof><rights>COPYRIGHT 2016 Knowledge Bylanes</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27524528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siddiqui, Emad Uddin</creatorcontrib><creatorcontrib>Kazi, Sayyeda Ghazala</creatorcontrib><creatorcontrib>Habib, Muhammad Irfan</creatorcontrib><creatorcontrib>Ahmed Khan, Khalid Mehmood</creatorcontrib><creatorcontrib>Zia, Nukhba</creatorcontrib><title>Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors.
The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis.
Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm.
Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bone Marrow Neoplasms - epidemiology</subject><subject>Central Nervous System Neoplasms - epidemiology</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Pakistan - epidemiology</subject><subject>Pediatrics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Recurrence (Disease)</subject><subject>Sex Factors</subject><subject>Tertiary Care Centers</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtLw0AUhbNQbK3-BRkQxE1lXklmlqX4goIu1G24Se60o5OHmcmi_94prWBB7uLC4TuH-zhJppQKOtda8Uly7v0npTxLKT1LJjxPuUy5miYfrxACDi3pDBnQQe-R2Jb0gLWFMNiKQDUGJG7b9JuudOBD1ByOX4CNhR0LJAYEC8OWVDAgGVsbLpJTA87j5aHPkveH-7fl03z18vi8XKzma0F1mJe0zhikkjGUmpkUTK4zyjkzVACTqqQSqc5AlUbXVay8NpyLXGhDjQQpZsntPrcfuu8RfSga6yt0DlrsRl8wxbhSnGYiotd7dA0OC9uaLgxQ7fBiITMmFFOSReruHypWHdetuhaNjfqR4eaPYYPgwsZ3bgy2a_0xeHUYdSwbrIt-sE28WfH7C_EDVLGCLA</recordid><startdate>20160831</startdate><enddate>20160831</enddate><creator>Siddiqui, Emad Uddin</creator><creator>Kazi, Sayyeda Ghazala</creator><creator>Habib, Muhammad Irfan</creator><creator>Ahmed Khan, Khalid Mehmood</creator><creator>Zia, Nukhba</creator><general>Knowledge Bylanes</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20160831</creationdate><title>Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit</title><author>Siddiqui, Emad Uddin ; Kazi, Sayyeda Ghazala ; Habib, Muhammad Irfan ; Ahmed Khan, Khalid Mehmood ; Zia, Nukhba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g309t-b0d61a5411e491f5af7960221f03a148b04e096a8bf9dcdcd7df223739f0f4a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Bone Marrow Neoplasms - epidemiology</topic><topic>Central Nervous System Neoplasms - epidemiology</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Pakistan - epidemiology</topic><topic>Pediatrics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Recurrence (Disease)</topic><topic>Sex Factors</topic><topic>Tertiary Care Centers</topic><toplevel>online_resources</toplevel><creatorcontrib>Siddiqui, Emad Uddin</creatorcontrib><creatorcontrib>Kazi, Sayyeda Ghazala</creatorcontrib><creatorcontrib>Habib, Muhammad Irfan</creatorcontrib><creatorcontrib>Ahmed Khan, Khalid Mehmood</creatorcontrib><creatorcontrib>Zia, Nukhba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siddiqui, Emad Uddin</au><au>Kazi, Sayyeda Ghazala</au><au>Habib, Muhammad Irfan</au><au>Ahmed Khan, Khalid Mehmood</au><au>Zia, Nukhba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2016-08-31</date><risdate>2016</risdate><volume>66</volume><issue>8</issue><spage>961</spage><epage>967</epage><pages>961-967</pages><issn>0030-9982</issn><abstract>To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors.
The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis.
Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm.
Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>27524528</pmid><tpages>7</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow Neoplasms - epidemiology Central Nervous System Neoplasms - epidemiology Chemotherapy Child Child, Preschool Diagnosis Female Humans Leukocyte Count Male Neoplasm Recurrence, Local - epidemiology Pakistan - epidemiology Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Prognosis Prospective Studies Recurrence (Disease) Sex Factors Tertiary Care Centers |
| title | Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit |
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