The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?
Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distingui...
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| Veröffentlicht in: | Tumor biology 2016-07, Vol.37 (7), p.9555-9563 |
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| creator | Sun, Yadong Liu, Xiaofeng Cui, Shude Li, Lianfang Tian, Peiqi Liu, Shanqing Li, Yong Yin, Mengmeng Zhang, Chongjian Mao, Qixin Wang, Jiaxiang |
| description | Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A patient can be benefited from chemotherapy. We retrospectively investigated the inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients, and analyzed the clinicopathologic characteristics, Recurrence score (RS), disease-free survival (DFS), and overall survival (OS) in 146 Luminal A breast cancer patients. The discordance of molecular subtypes between primary foci and metastatic lymph nodes were explored by univariate and multivariate logistic regression. The DFS and OS were calculated by the Kaplan–Meier survival curves, and the Cox regression analyses were performed to identify independent prognostic factors for DFS and OS. In our results, the inconsistency was found in 55 patients (55/146, 37.67 %). Lymphatic vascular invasion (OR 6.402, 95 % CI 2.371–17.287,
P
|
| doi_str_mv | 10.1007/s13277-016-4844-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1812879232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1812879232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-9a78a24b85cb6893132348593bd2c0949ddc1694bf1f63f8ceea4fe835dbf9383</originalsourceid><addsrcrecordid>eNp1kc-KFDEQxoMo7jr6AF4k4MWDrfnX3clJlmFXhQEv67lJp6t3snSSNkmz24_m25mhRxHBUxXU7_uKqg-h15R8oIS0HxPlrG0rQptKSCEq-gRdUsF4RbgkT0tPKKkEk_wCvUjpnhBaK9U8RxesaRURor5EP2-PgK03wSebMniz4jBiFyYwy6QjTkuf1xkS7iE_AHg8R-t0XPEYjMXaD9hB1inrbA3Wj3aaTsNpdfMR-zAUofX4sDjr9YSvcB-hwNhobyDiuajA54S1C_4O74_WQwL8EBz498W8aAdrChR82RexOYIL-QhRz-unl-jZqKcEr851h77fXN_uv1SHb5-_7q8OleEty5XSrdRM9LI2fSMVLy_jQtaK9wMzRAk1DIY2SvQjHRs-SgOgxQiS10M_Ki75Dr3bfOcYfiyQcudsMlAO9RCW1FFJmWwVK7479PYf9D4ssVy-UZzUkpBC0Y0yMaQUYezOP-0o6U65dluuXcm1O-Xa0aJ5c3ZeegfDH8XvIAvANiCVkb-D-Nfq_7r-Al7esXs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1812305800</pqid></control><display><type>article</type><title>The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?</title><source>MEDLINE</source><source>SpringerLink Journals (MCLS)</source><creator>Sun, Yadong ; Liu, Xiaofeng ; Cui, Shude ; Li, Lianfang ; Tian, Peiqi ; Liu, Shanqing ; Li, Yong ; Yin, Mengmeng ; Zhang, Chongjian ; Mao, Qixin ; Wang, Jiaxiang</creator><creatorcontrib>Sun, Yadong ; Liu, Xiaofeng ; Cui, Shude ; Li, Lianfang ; Tian, Peiqi ; Liu, Shanqing ; Li, Yong ; Yin, Mengmeng ; Zhang, Chongjian ; Mao, Qixin ; Wang, Jiaxiang</creatorcontrib><description>Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A patient can be benefited from chemotherapy. We retrospectively investigated the inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients, and analyzed the clinicopathologic characteristics, Recurrence score (RS), disease-free survival (DFS), and overall survival (OS) in 146 Luminal A breast cancer patients. The discordance of molecular subtypes between primary foci and metastatic lymph nodes were explored by univariate and multivariate logistic regression. The DFS and OS were calculated by the Kaplan–Meier survival curves, and the Cox regression analyses were performed to identify independent prognostic factors for DFS and OS. In our results, the inconsistency was found in 55 patients (55/146, 37.67 %). Lymphatic vascular invasion (OR 6.402, 95 % CI 2.371–17.287,
P
< 0.001), lymph node stage (OR 2.147, 95 % CI 1.095–4.209,
P
= 0.026), and histological grade (OR 3.319, 95 % CI 1.101–8.951,
P
= 0.032) were significantly related to the inconsistency. The inconsistent group (non-Luminal A variations) had a poor prognosis compared with the consistent group, the DFS between the two groups was significantly different (
P
= 0.022), but the OS did not have obvious difference (
P
= 0.140). Moreover, the inconsistency was associated with high RS (
P
= 0.036). In conclusion, more aggressive molecular subtypes in metastatic lymph nodes, which associated with poor prognosis, were observed in Luminal A breast cancer patients, which indicate that chemotherapy is necessary for these patients.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-016-4844-1</identifier><identifier>PMID: 26790445</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Antineoplastic Agents - therapeutic use ; Asian Continental Ancestry Group ; Axilla - pathology ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cancer Research ; Chemotherapy ; Chemotherapy, Adjuvant - methods ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Lymphatic system ; Medical prognosis ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Original Article ; Prognosis ; Retrospective Studies</subject><ispartof>Tumor biology, 2016-07, Vol.37 (7), p.9555-9563</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9a78a24b85cb6893132348593bd2c0949ddc1694bf1f63f8ceea4fe835dbf9383</citedby><cites>FETCH-LOGICAL-c372t-9a78a24b85cb6893132348593bd2c0949ddc1694bf1f63f8ceea4fe835dbf9383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-016-4844-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-016-4844-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26790445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yadong</creatorcontrib><creatorcontrib>Liu, Xiaofeng</creatorcontrib><creatorcontrib>Cui, Shude</creatorcontrib><creatorcontrib>Li, Lianfang</creatorcontrib><creatorcontrib>Tian, Peiqi</creatorcontrib><creatorcontrib>Liu, Shanqing</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Yin, Mengmeng</creatorcontrib><creatorcontrib>Zhang, Chongjian</creatorcontrib><creatorcontrib>Mao, Qixin</creatorcontrib><creatorcontrib>Wang, Jiaxiang</creatorcontrib><title>The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A patient can be benefited from chemotherapy. We retrospectively investigated the inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients, and analyzed the clinicopathologic characteristics, Recurrence score (RS), disease-free survival (DFS), and overall survival (OS) in 146 Luminal A breast cancer patients. The discordance of molecular subtypes between primary foci and metastatic lymph nodes were explored by univariate and multivariate logistic regression. The DFS and OS were calculated by the Kaplan–Meier survival curves, and the Cox regression analyses were performed to identify independent prognostic factors for DFS and OS. In our results, the inconsistency was found in 55 patients (55/146, 37.67 %). Lymphatic vascular invasion (OR 6.402, 95 % CI 2.371–17.287,
P
< 0.001), lymph node stage (OR 2.147, 95 % CI 1.095–4.209,
P
= 0.026), and histological grade (OR 3.319, 95 % CI 1.101–8.951,
P
= 0.032) were significantly related to the inconsistency. The inconsistent group (non-Luminal A variations) had a poor prognosis compared with the consistent group, the DFS between the two groups was significantly different (
P
= 0.022), but the OS did not have obvious difference (
P
= 0.140). Moreover, the inconsistency was associated with high RS (
P
= 0.036). In conclusion, more aggressive molecular subtypes in metastatic lymph nodes, which associated with poor prognosis, were observed in Luminal A breast cancer patients, which indicate that chemotherapy is necessary for these patients.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Asian Continental Ancestry Group</subject><subject>Axilla - pathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant - methods</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-KFDEQxoMo7jr6AF4k4MWDrfnX3clJlmFXhQEv67lJp6t3snSSNkmz24_m25mhRxHBUxXU7_uKqg-h15R8oIS0HxPlrG0rQptKSCEq-gRdUsF4RbgkT0tPKKkEk_wCvUjpnhBaK9U8RxesaRURor5EP2-PgK03wSebMniz4jBiFyYwy6QjTkuf1xkS7iE_AHg8R-t0XPEYjMXaD9hB1inrbA3Wj3aaTsNpdfMR-zAUofX4sDjr9YSvcB-hwNhobyDiuajA54S1C_4O74_WQwL8EBz498W8aAdrChR82RexOYIL-QhRz-unl-jZqKcEr851h77fXN_uv1SHb5-_7q8OleEty5XSrdRM9LI2fSMVLy_jQtaK9wMzRAk1DIY2SvQjHRs-SgOgxQiS10M_Ki75Dr3bfOcYfiyQcudsMlAO9RCW1FFJmWwVK7479PYf9D4ssVy-UZzUkpBC0Y0yMaQUYezOP-0o6U65dluuXcm1O-Xa0aJ5c3ZeegfDH8XvIAvANiCVkb-D-Nfq_7r-Al7esXs</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Sun, Yadong</creator><creator>Liu, Xiaofeng</creator><creator>Cui, Shude</creator><creator>Li, Lianfang</creator><creator>Tian, Peiqi</creator><creator>Liu, Shanqing</creator><creator>Li, Yong</creator><creator>Yin, Mengmeng</creator><creator>Zhang, Chongjian</creator><creator>Mao, Qixin</creator><creator>Wang, Jiaxiang</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?</title><author>Sun, Yadong ; Liu, Xiaofeng ; Cui, Shude ; Li, Lianfang ; Tian, Peiqi ; Liu, Shanqing ; Li, Yong ; Yin, Mengmeng ; Zhang, Chongjian ; Mao, Qixin ; Wang, Jiaxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9a78a24b85cb6893132348593bd2c0949ddc1694bf1f63f8ceea4fe835dbf9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>Asian Continental Ancestry Group</topic><topic>Axilla - pathology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant - methods</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yadong</creatorcontrib><creatorcontrib>Liu, Xiaofeng</creatorcontrib><creatorcontrib>Cui, Shude</creatorcontrib><creatorcontrib>Li, Lianfang</creatorcontrib><creatorcontrib>Tian, Peiqi</creatorcontrib><creatorcontrib>Liu, Shanqing</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Yin, Mengmeng</creatorcontrib><creatorcontrib>Zhang, Chongjian</creatorcontrib><creatorcontrib>Mao, Qixin</creatorcontrib><creatorcontrib>Wang, Jiaxiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yadong</au><au>Liu, Xiaofeng</au><au>Cui, Shude</au><au>Li, Lianfang</au><au>Tian, Peiqi</au><au>Liu, Shanqing</au><au>Li, Yong</au><au>Yin, Mengmeng</au><au>Zhang, Chongjian</au><au>Mao, Qixin</au><au>Wang, Jiaxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>37</volume><issue>7</issue><spage>9555</spage><epage>9563</epage><pages>9555-9563</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A patient can be benefited from chemotherapy. We retrospectively investigated the inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients, and analyzed the clinicopathologic characteristics, Recurrence score (RS), disease-free survival (DFS), and overall survival (OS) in 146 Luminal A breast cancer patients. The discordance of molecular subtypes between primary foci and metastatic lymph nodes were explored by univariate and multivariate logistic regression. The DFS and OS were calculated by the Kaplan–Meier survival curves, and the Cox regression analyses were performed to identify independent prognostic factors for DFS and OS. In our results, the inconsistency was found in 55 patients (55/146, 37.67 %). Lymphatic vascular invasion (OR 6.402, 95 % CI 2.371–17.287,
P
< 0.001), lymph node stage (OR 2.147, 95 % CI 1.095–4.209,
P
= 0.026), and histological grade (OR 3.319, 95 % CI 1.101–8.951,
P
= 0.032) were significantly related to the inconsistency. The inconsistent group (non-Luminal A variations) had a poor prognosis compared with the consistent group, the DFS between the two groups was significantly different (
P
= 0.022), but the OS did not have obvious difference (
P
= 0.140). Moreover, the inconsistency was associated with high RS (
P
= 0.036). In conclusion, more aggressive molecular subtypes in metastatic lymph nodes, which associated with poor prognosis, were observed in Luminal A breast cancer patients, which indicate that chemotherapy is necessary for these patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26790445</pmid><doi>10.1007/s13277-016-4844-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Antineoplastic Agents - therapeutic use Asian Continental Ancestry Group Axilla - pathology Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Research Chemotherapy Chemotherapy, Adjuvant - methods Disease-Free Survival Female Humans Kaplan-Meier Estimate Lymph Nodes - pathology Lymphatic Metastasis - pathology Lymphatic system Medical prognosis Metastasis Middle Aged Neoplasm Recurrence, Local - pathology Original Article Prognosis Retrospective Studies |
| title | The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy? |
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