Targeting non-canonical autophagy overcomes erlotinib resistance in tongue cancer

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) frequently occurs in many human cancers and hampers their therapeutic use. A large body of evidence has demonstrated the pro-survival role of autophagy in many human cancers. However, whether autophagy is in...

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Veröffentlicht in:	Tumor biology 2016-07, Vol.37 (7), p.9625-9633
Hauptverfasser:	huang, Keqiang, liu, Dongxu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - metabolism Antineoplastic Combined Chemotherapy Protocols - pharmacology Autophagy Autophagy - drug effects Autophagy-Related Protein 5 - metabolism Beclin-1 - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Cell Line, Tumor Cell Survival - drug effects Drug Resistance, Neoplasm - drug effects Erlotinib Hydrochloride - pharmacology Humans Hydroxychloroquine - pharmacology Oral cancer Original Article Pharmacology Protein expression RNA, Small Interfering - metabolism Sirolimus - pharmacology Tongue Neoplasms - drug therapy Tongue Neoplasms - metabolism Up-Regulation - drug effects
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